Patents by Inventor Annie Lang

Annie Lang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Optically pure compounds for improved therapeutic efficiency
    Patent number: 9243030
    Abstract: The present invention relates to new optically pure compounds displaying an improved anticancer activity compared to previously known complex mixtures of stereoisomers thereof. Such compounds are of formula (I): wherein each X independently represents any amino acid; n is 0 or 1; m is an integer between 0 and 3; k is an integer of at least 3; Psi is a reduced bond of formula replacing the peptide amide bond between Lys and Pro; and wherein Lys residues in pseudopeptide units of said compound of formula (I) are either all in L configuration or all in D configuration. A method for preparing such compounds, and therapeutic uses thereof are also provided. The synthetic method involves the selective reduction of the peptide bond between Lys and Pro in a dipeptide intermediate with borane. The therapeutic uses are against cancer, inflammation and for wound healing.
    Type: Grant
    Filed: May 22, 2008
    Date of Patent: January 26, 2016
    Assignees: Centre National De La Recherche Scientifique (CNRS), ELRO Pharma Sarl
    Inventors: Jean Paul Briand, Gilles Guichard, Jose Courty, Robert H. Zimmer, Chantal Devin, Annie Lang, Haixang Zhang, Ara Hovanessian
  • New Optically Pure Compounds for Improved Therapeutic Efficiency
    Publication number: 20110201559
    Abstract: The present invention relates to new optically pure compounds displaying an improved anticancer activity compared to previously known complex mixtures of stereoisomers thereof. Such compounds are of formula (I): wherein each X independently represents any amino acid; n is 0 or 1; m is an integer between 0 and 3; k is an integer of at least 3; Psi is a reduced bond of formula replacing the peptide amide bond between Lys and Pro; and wherein Lys residues in pseudopeptide units of said compound of formula (I) are either all in L configuration or all in D configuration. A method for preparing such compounds, and therapeutic uses thereof are also provided. The synthetic method involves the selective reduction of the peptide bond between Lys and Pro in a dipeptide intermediate with borane. The therapeutic uses are against cancer, inflammation and for wound healing.
    Type: Application
    Filed: May 22, 2008
    Publication date: August 18, 2011
    Inventors: Jean Paul Briand, Gilles Guichard, José Courty, Robert Zimmer, Chantal Devin, Annie Lang, Haixiang Zhang