Abstract: The present invention relates to the use of Raman spectroscopy for quantitative, non-invasive transcutaneous measurement of blood analytes, such as glucose. Raman spectroscopy is used to measure glucose transcutaneously, in patients whose blood glucose levels were monitored. Raman spectra were collected transcutaneously along with glucose reference values provided by standard capillary blood analysis. A partial least squares calibration was created from the data from each subject and validated using leave-one-out cross validation.

Abstract: The present invention relates to the use of Raman spectroscopy for quantitative, non-invasive transcutaneous measurement of blood analytes, such as glucose. Raman spectroscopy is used to measure glucose transcutaneously, in patients whose blood glucose levels were monitored. Raman spectra were collected transcutaneously along with glucose reference values provided by standard capillary blood analysis. A partial least squares calibration was created from the data from each subject and validated using leave-one-out cross validation.

Abstract: Methods are disclosed for analysing the concentration of red blood cells in a flow of blood including flowing the blood through a cuvette, directing a light through the flow of blood, measuring light transmitted through the flow of blood to obtain a transmitted signal, measuring scattered light at a predetermined angle with respect to the direct transmission path through the flow of blood to obtain a scattered signal, and providing a ratio signal comprising the ratio between the scattered signal and the transmitted signal. Apparatus for analysing the concentration of red blood cells is also disclosed.