Abstract: The present invention relates to an aqueous solution comprising burlulipase which is characterized in that it contains calcium ions. In particular, it also relates to corresponding pharmaceuticals. Such pharmaceuticals are suitable for the treatment of exocrine pancreatic insufficiency. These pharmaceuticals are particularly suitable for treating patients having cystic fibrosis and in pediatrics. Another aspect of the present invention relates to container-packaged solutions and pharmaceuticals as mentioned above, which are containers produced by the blow-fill-seal method, and to methods for producing such packaged solutions and pharmaceuticals.

Abstract: The present invention relates to an aqueous solution comprising burlulipase which is characterized in that it contains calcium ions. In particular, it also relates to corresponding pharmaceuticals. Such pharmaceuticals are suitable for the treatment of exocrine pancreatic insufficiency. These pharmaceuticals are particularly suitable for treating patients having cystic fibrosis and in pediatrics. Another aspect of the present invention relates to container-packaged solutions and pharmaceuticals as mentioned above, which are containers produced by the blow-fill-seal method, and to methods for producing such packaged solutions and pharmaceuticals.

Abstract: A sealing device for sealing a lead-through for a medical instrument that includes a fastening region for fastening the sealing device on a tube or other medical device, a ring-like supporting region which is connected to the fastening region, and an annular sealing lip with an outer edge which is connected to an inner edge of the support portion, and an inner edge which is provided and designed to fluid-tightly abut at an outer surface of a shaft inserted in the sealing device. The difference of the average diameter of the inner edge of the support portion and the mean diameter of a shaft of a medical instrument, for which the sealing device is provided and designed, is not larger than the difference of the average diameter of the shaft and the mean diameter of the inner edge of the sealing lip.

Abstract: An endoscopic instrument including first, second and third portions, a first main hinge with a first main-hinge part, a further first main-hinge part and a first sub-hinge, a second main hinge with a second main-hinge part, a further second main-hinge part and a second sub-hinge, and a rigid main pressure rod. The first and second portions are connected via the first main hinge, such that the first and second portions can be angled. The first and third portions are connected via the second main hinge such that the first and third portions can be angled. The main pressure rod is coupled to the first and second sub-hinges, so that displacement of the first main hinge by angling the second portion relative to the first portion transmits a force, via the main pressure rod, to the second main hinge and causes an angling of the third portion relative to the first portion.

Abstract: The present invention relates to an aqueous solution comprising burlulipase which is characterized in that it contains calcium ions. In particular, it also relates to corresponding pharmaceuticals. Such pharmaceuticals are suitable for the treatment of exocrine pancreatic insufficiency. These pharmaceuticals are particularly suitable for treating patients having cystic fibrosis and in pediatrics. Another aspect of the present invention relates to container-packaged solutions and pharmaceuticals as mentioned above, which are containers produced by the blow-fill-seal method, and to methods for producing such packaged solutions and pharmaceuticals.

Abstract: A sealing device (30) for sealing a lead-through for a medical instrument (20) comprises a fastening region (36) for fastening the sealing device (30) on a tube (10) or other medical device, a ring-like supporting region (40) which is connected to the fastening region (36), and an annular sealing lip (50) with an outer edge (52) which is connected to an inner edge (44) of the support portion (40), and an inner edge (54) which is provided and designed to fluid-tightly abut at an outer surface of a shaft (20) inserted in the sealing device (30). The difference (D2?DS) of the average diameter (D2) of the inner edge (44) of the support portion (40) and the mean diameter (DS) of a shaft (20) of a medical instrument, for which the sealing device (30) is provided and designed, is not larger than the difference (DS?D1) of the average diameter (DS) of the shaft (20) and the mean diameter (D1) of the inner edge (54) of the sealing lip (50) (D2?DS?DS?D1).

Abstract: Endoscopic instrument including first, second and third portions, a first main hinge with a first main-hinge part, a further first main-hinge part and a first sub-hinge, a second main hinge with a second main-hinge part, a further second main-hinge part and a second sub-hinge, and a rigid main pressure rod. The first and second portions are connected via the first main hinge, such that they can be angled. The first and third portions are connected via the second main hinge such that they can be angled. The main pressure rod is coupled to the first and second sub-hinges, so that displacement of the first main hinge by angling the second portion relative to the first portion transmits a force, via the main pressure rod, to the second main hinge and causes there an angling of the third portion relative to the first portion.