Abstract: An example network system includes a plurality of endpoint computing resources, a business policy graph of a network that includes a set of the plurality of endpoint computing resources configured as a security domain, a set of policy enforcement points (“PEPs”) configured to enforce network policies, and a network management module (“NMM”). The NMM is configured to receive an indication of a set of network policies to apply to the security domain, automatically determine a subset of PEPs of the set of PEPs are required to enforce the set of network policies based on physical network topology information readable by the NMM that includes information about the location of the endpoint computing resources and the set of PEPs within the network, and apply the network policies to the subset of PEPs in order to enforce the network policies against the set of endpoint computing resources of the security domain.