Patents by Inventor Anson V. Hatch
Anson V. Hatch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10627366Abstract: Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction.Type: GrantFiled: January 16, 2017Date of Patent: April 21, 2020Assignee: National Technology & Engineering Solutions of Sandia, LLCInventors: Ronald F. Renzi, Gregory J. Sommer, Anup K. Singh, Anson V. Hatch, Mark R. Claudnic, Ying-Chih Wang, James L. Van De Vreugde
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Publication number: 20170122904Abstract: Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction.Type: ApplicationFiled: January 16, 2017Publication date: May 4, 2017Inventors: Ronald F. Renzi, Gregory J. Sommer, Anup K. Singh, Anson V. Hatch, Mark R. Claudnic, Ying-Chih Wang, James L. Van De Vreugde
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Patent number: 9579649Abstract: Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction.Type: GrantFiled: October 7, 2010Date of Patent: February 28, 2017Assignee: Sandia CorporationInventors: Ronald F. Renzi, Gregory J. Sommer, Anup K. Singh, Anson V. Hatch, Mark R. Claudnic, Ying-Chih Wang, James L. Van de Vreugde
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Patent number: 9409357Abstract: Embodiments of the present invention provide devices, systems, and methods for microscale isoelectric fractionation. Analytes in a sample may be isolated according to their isoelectric point within a fractionation microchannel. A microfluidic device according to an embodiment of the invention includes a substrate at least partially defining a fractionation microchannel. The fractionation microchannel has at least one cross-sectional dimension equal to or less than 1 mm. A plurality of membranes of different pHs are disposed in the microchannel. Analytes having an isoelectric point between the pH of the membranes may be collected in a region of the fractionation channel between the first and second membranes through isoelectric fractionation.Type: GrantFiled: January 23, 2013Date of Patent: August 9, 2016Assignee: Sandia CorporationInventors: Gregory J. Sommer, Anson V. Hatch, Ying-Chih Wang, Anup K. Singh
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Patent number: 9201069Abstract: Microfluidic devices and methods including porous polymer monoliths are described. Polymerization techniques may be used to generate porous polymer monoliths having pores defined by a liquid component of a fluid mixture. The fluid mixture may contain iniferters and the resulting porous polymer monolith may include surfaces terminated with iniferter species. Capture molecules may then be grafted to the monolith pores.Type: GrantFiled: February 25, 2014Date of Patent: December 1, 2015Assignee: Sandia CorporationInventors: Anson V. Hatch, Gregory J. Sommer, Anup K. Singh, Ying-Chih Wang, Vinay Abhyankar
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Patent number: 9005417Abstract: Embodiments of the present invention provide devices, systems, and methods for microscale isoelectric fractionation. Analytes in a sample may be isolated according to their isoelectric point within a fractionation microchannel. A microfluidic device according to an embodiment of the invention includes a substrate at least partially defining a fractionation microchannel. The fractionation microchannel has at least one cross-sectional dimension equal to or less than 1 mm. A plurality of membranes of different pHs are disposed in the microchannel. Analytes having an isoelectric point between the pH of the membranes may be collected in a region of the fractionation channel between the first and second membranes through isoelectric fractionation.Type: GrantFiled: October 1, 2008Date of Patent: April 14, 2015Assignee: Sandia CorporationInventors: Gregory J. Sommer, Anson V. Hatch, Ying-Chih Wang, Anup K. Singh
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Publication number: 20150038372Abstract: Embodiments of the present invention provide methods, microfluidic devices, and systems for the detection of an active target agent in a fluid sample. A substrate molecule is used that contains a sequence which may cleave in the presence of an active target agent. A SNAP25 sequence is described, for example, that may be cleaved in the presence of Botulinum Neurotoxin. The substrate molecule includes a reporter moiety. The substrate molecule is exposed to the sample, and resulting reaction products separated using electrophoretic separation. The elution time of the reporter moiety may be utilized to identify the presence or absence of the active target agent.Type: ApplicationFiled: September 24, 2014Publication date: February 5, 2015Inventors: Gregory J. Sommer, Anson V. Hatch, Anup K. Singh, Ying-Chih Wang
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Patent number: 8945914Abstract: Embodiments of the present invention are directed toward devices, systems, and method for conducting sandwich assays using sedimentation. In one example, a method includes generating complexes on a plurality of beads in a fluid sample, individual ones of the complexes comprising a capture agent, a target analyte, and a labeling agent. The plurality of beads including the complexes may be transported through a density media, wherein the density media has a density lower than a density of the beads and higher than a density of the fluid sample, and wherein the transporting occurs, at least in part, by sedimentation. Signal may be detected from the labeling agents of the complexes.Type: GrantFiled: September 28, 2010Date of Patent: February 3, 2015Assignee: Sandia CorporationInventors: Ulrich Y. Schaff, Gregory J. Sommer, Anup K. Singh, Anson V. Hatch
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Patent number: 8871496Abstract: Embodiments of the present invention provide methods, microfluidic devices, and systems for the detection of an active target agent in a fluid sample. A substrate molecule is used that contains a sequence which may cleave in the presence of an active target agent. A SNAP25 sequence is described, for example, that may be cleaved in the presence of Botulinum Neurotoxin. The substrate molecule includes a reporter moiety. The substrate molecule is exposed to the sample, and resulting reaction products separated using electrophoretic separation. The elution time of the reporter moiety may be utilized to identify the presence or absence of the active target agent.Type: GrantFiled: August 20, 2009Date of Patent: October 28, 2014Assignee: Sandia CorporationInventors: Gregory J. Sommer, Anson V. Hatch, Anup K. Singh, Ying-Chih Wang
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Publication number: 20140178252Abstract: Microfluidic devices and methods including porous polymer monoliths are described. Polymerization techniques may be used to generate porous polymer monoliths having pores defined by a liquid component of a fluid mixture. The fluid mixture may contain iniferters and the resulting porous polymer monolith may include surfaces terminated with iniferter species. Capture molecules may then be grafted to the monolith pores.Type: ApplicationFiled: February 25, 2014Publication date: June 26, 2014Applicant: Sandia CorporationInventors: Anson V. Hatch, Gregory J. Sommer, Anup K. Singh, Ying-Chih Wang, Vinay Abhyankar
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Patent number: 8728290Abstract: Disclosed is a novel microfluidic device enabling on-chip implementation of a two-dimensional separation methodology. Previously disclosed microscale immobilized pH gradients (IPG) are combined with perpendicular polyacrylamide gel electrophoresis (PAGE) microchannels to achieve orthogonal separations of biological samples. Device modifications enable inclusion of sodium dodecyl sulfate (SDS) in the second dimension. The device can be fabricated to use either continuous IPG gels, or the microscale isoelectric fractionation membranes we have also previously disclosed, for the first dimension. The invention represents the first all-gel two-dimensional separation microdevice, with significantly higher resolution power over existing devices.Type: GrantFiled: November 2, 2012Date of Patent: May 20, 2014Assignee: Sandia CorporationInventors: Gregory J. Sommer, Anson V. Hatch, Anup K. Singh, Ying-Chih Wang
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Patent number: 8703058Abstract: Microfluidic devices and methods including porous polymer monoliths are described. Polymerization techniques may be used to generate porous polymer monoliths having pores defined by a liquid component of a fluid mixture. The fluid mixture may contain iniferters and the resulting porous polymer monolith may include surfaces terminated with iniferter species. Capture molecules may then be grafted to the monolith pores.Type: GrantFiled: September 9, 2009Date of Patent: April 22, 2014Assignee: Sandia CorporationInventors: Anson V. Hatch, Gregory J. Sommer, Anup K. Singh, Ying-Chih Wang, Vinay V. Abhyankar
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Patent number: 8394312Abstract: Methods for making a microfluidic device according to embodiments of the present invention include defining˜cavity. Polymer precursor solution is positioned in the cavity, and exposed to light to begin the polymerization process and define a microchannel. In some embodiments, after the polymerization process is partially complete, a solvent rinse is performed, or fresh polymer precursor introduced into the microchannel. This may promote removal of unpolymerized material from the microchannel and enable smaller feature sizes. The polymer precursor solution may contain an iniferter. Polymerized features therefore may be capped with the iniferter, which is photoactive. The iniferter may aid later binding of a polyacrylamide gel to the microchannel surface.Type: GrantFiled: September 20, 2011Date of Patent: March 12, 2013Assignee: Sandia CorporationInventors: Gregory J. Sommer, Anson V. Hatch, Ying-Chih Wang, Anup K. Singh, Ronald F. Renzi, Mark R. Claudnic
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Patent number: 8329016Abstract: Disclosed is a novel microfluidic device enabling on-chip implementation of a two-dimensional separation methodology. Previously disclosed microscale immobilized pH gradients (IPG) are combined with perpendicular polyacrylamide gel electrophoresis (PAGE) microchannels to achieve orthogonal separations of biological samples. Device modifications enable inclusion of sodium dodecyl sulfate (SDS) in the second dimension. The device can be fabricated to use either continuous IPG gels, or the microscale isoelectric fractionation membranes we have also previously disclosed, for the first dimension. The invention represents the first all-gel two-dimensional separation microdevice, with significantly higher resolution power over existing devices.Type: GrantFiled: August 31, 2009Date of Patent: December 11, 2012Assignee: Sandia CorporationInventors: Gregory J. Sommer, Anson V. Hatch, Anup K. Singh, Ying-Chih Wang
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Publication number: 20120085644Abstract: Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction.Type: ApplicationFiled: October 7, 2010Publication date: April 12, 2012Inventors: Ronald F. Renzi, Gregory J. Sommer, Anup K. Singh, Anson V. Hatch, Mark R. Claudnic, Ying-Chih Wang, James L. Van De Vreugde
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Patent number: 8047829Abstract: Methods for making a micofluidic device according to embodiments of the present invention include defining a cavity. Polymer precursor solution is positioned in the cavity, and exposed to light to begin the polymerization process and define a microchannel. In some embodiments, after the polymerization process is partially complete, a solvent rinse is performed, or fresh polymer precursor introduced into the microchannel. This may promote removal of unpolymerized material from the microchannel and enable smaller feature sizes. The polymer precursor solution may contain an iniferter. Polymerized features therefore may be capped with the iniferter, which is photoactive. The iniferter may aid later binding of a polyacrylamide gel to the microchannel surface.Type: GrantFiled: January 26, 2009Date of Patent: November 1, 2011Assignee: Sandia CorporationInventors: Gregory J. Sommer, Anson V. Hatch, Ying-Chih Wang, Anup K. Singh, Ronald F. Renzi, Mark R. Claudnic