Patents by Inventor Antal Gajary
Antal Gajary has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7462725Abstract: The process according to the invention relates to the preparation of 2-chloromethyl-thiophene of the formula (I). During this process thiophene is chloromethylated in the presence of one or more compounds containing keto group and optionally it is transformed into the compound of the formula (II). Compounds of formula (I) and (II) are intermediates of several pharmaceutically active ingredients.Type: GrantFiled: May 16, 2002Date of Patent: December 9, 2008Assignee: Sanofi-AventisInventors: Mátyás Aradi, Ferenc Bakos, Zsolt Dombrády, Antal Gajáry, István Gyöngyösi, Ferenc Kovács, Andrea Major, Erika Máténé Török, Zsolt Párkányi, László Schultz, Attila Supic, Sándor Szabó, Erzsébet Szalay, József Ugrics, József Zsiga
-
Patent number: 7381835Abstract: The subject of the present invention is the preparation of the (R)-(?)-2-hydroxy-2-(2-chlorophenyl)acetic acid of the formula (I) by the resolution of the corresponding racemic compound by using the compounds of the general formula (II).Type: GrantFiled: June 14, 2002Date of Patent: June 3, 2008Assignee: Sanofi-AventisInventors: József Bálint, Marianna Csatáriné Nagy, Zsolt Dombrády, Elemér Fogassy, Antal Gajáry, Charles Suba
-
Publication number: 20060161008Abstract: The process according to the invention relates to the preparation of 2-chloromethyl-thiophene of the formula (I). During this process thiophene is chloromethylated in the presence of one or more compounds containing keto group and optionally it is transformed into the compound of the formula (II). Compounds of formula (I) and (II) are intermediates of several pharmaceutically active ingredients.Type: ApplicationFiled: May 16, 2002Publication date: July 20, 2006Inventors: Matyas Aradi, Ferenc Bakos, Zsolt Dombrady, Antal Gajary, Istvan Gyongyosi, Ferenc Kovacs, Andrea Major, Erika Matene Torok, Zsolt Parkanyi, Laszlo Schultz, Attila Supic, Sandor Szabom, Erzsebet Szalay, Jozsef Ugrics, Jozsef Zsiga
-
Publication number: 20040242921Abstract: The subject of the present invention is the preparation of the (R)-(−)-2-hydroxy-2-(2-chlorophenyl)acetic acid of the formula (I) by the resolution of the corresponding racernic compound by using the compounds of the general formula (II).Type: ApplicationFiled: June 25, 2004Publication date: December 2, 2004Inventors: Jozsef Balint, Marianna Csatarine Nagy, Zsolt Dombrady, Elemer Fogassy, Antal Gajary, Charles Suba
-
Patent number: 6239286Abstract: Process for the preparation of compounds of formula (I) wherein R means hydrogen atom, or C1-6 alkyl group, or C7-12 aralkyl group or phenyl group, characterised in that: a) the compound of formula (III) is reacted with a compound of formula (IV) wherein X means halogen atom or C1-5 alkoxy group or hydroxyl group and the resulting compound of formula (II) is transformed in the presence of an oxidising agent in a reaction medium with pH above 7, into the compound of formula (I), or b) the compound of formula (III) is reacted with an anhydride of general formula (V) and the resulting compound of formula (II) transformed in the presence of an oxidising agent, in a reaction medium with pH above 7, into the compound of formula (I), or c) a compound of formula (II) is transformed in the presence of an oxidising agent, in a reaction medium with pH above 7, into the compound of formula (I), and if desired, the resulting compounds of formula (I), before or after isolation, are transformed into acid addition salts, orType: GrantFiled: May 15, 2000Date of Patent: May 29, 2001Assignee: Sanofi-SynthelaboInventors: Attila Kis-Tamás, Csaba Huszár, Bertrand Castro, Attila Németh, Péter Aranyosi, Károly Gyüre, István Mészáros, Ilona Dervalicsné Zrínyi, Katalin Dubovszki, Lajosné Páli, Antal Gajáry, Attila Supic, Zsuzsanna Nád, Zoltán Makovi, Endre Kollár, Zsuzsanna Csetriné Hári, Ágnes Kunsztné Kárász, Erzsébet Bognár
-
Patent number: 6211382Abstract: Process for the preparation of compounds of formula (I) wherein R means hydrogen atom, or C1-6 alkyl group, or C7-12 aralkyl group or phenyl group, characterised in that a) the compound of formula (III) is reacted with a compound of formula (IV) wherein X means halogen atom or C1-5 alkoxy group or hydroxyl group, and the resulting compound of formula (II) is transformed, in a reaction medium with pH above 7, into the compound of formula (I) or b) the compound of formula (III) is reacted with an anhydride of general formula (V) and the resulting compound of formula (II) transformed, in a reaction medium with pH above 7, into the compound of formula (I), or c) a compound of formula (II) is transformed, in a reaction medium with pH above 7, into the compound of formula (I), and if desired, the resulting compounds of formula (I), before or after isolation, are transformed into acid addition salts, or the compounds of formula (I) are liberated from their acid addition salts.Type: GrantFiled: April 13, 2000Date of Patent: April 3, 2001Assignee: Sanofi-SynthelaboInventors: Csaba Huszár, Attila Kis-Tamás, Attila Németh, Zsuzsanna Nád, Zoltán Makovi, Antal Gajáry, Endre Kollár, Péter Aranyosi, Károly Gyüre, István Mészáros, Zsuzsanna Csetriné Hári, Attila Supic, Ilona Dervalicsne Zrinyi, Katalin Dubovszki, Lajosné Páli, Ágnes Kunsztné Kárász, Erzsébet Bognár
-
Patent number: 6162923Abstract: The present invention relates to a process for the preparation of a compound of general formula (I), ##STR1## wherein R.sup.1 represents a hydrogen atom or an alkyl group of 1-6 carbon atoms, and their salts, wherein the compound of formula (II): ##STR2## is reacted with a compound of formula (III): ##STR3## wherein R represents an alkyl group of 1-4 carbon atoms and R.sup.1 is the same as defined above, by heating their neutral pH mixtures at the boiling temperature of the mixture, and the resulting compound of general formula (IV): ##STR4## wherein R and R.sup.1 are the same as defined above, is cyclized into the compound of general formula (I) by further elevating the temperature of the neutral mixture, and if desired, the compounds of general formula (I) are transformed into their salts, or the compounds of general formula (I) are liberated from their salts.Type: GrantFiled: April 26, 2000Date of Patent: December 19, 2000Assignee: Sanofi-SynthelaboInventors: Csaba Huszar, Attila Kis-Tamas, Attila Nemeth, Antal Gajary, Lajosne Pali
-
Patent number: 5278309Abstract: A pure crystalline O-(2-hydroxy-3-piperidino-1-propyl) nicotinic acid amidoxime base of the Formula (Ib) ##STR1## is disclosed characterized by a melting point of 70.degree. to 73.degree. C., giving, when dissolved in an amount of 1 to 10 ml of concentrated sulfuric acid, a yellow homogeneous solution, and showing the following spectral characteristics:IR spectrum (kBr): .gamma. --O--C.dbd.N 1642 cm.sup.-1.sup.1 H-NMR spectrum (CDCL.sub.3, .delta. ppm): 1.48 m, (6H), CH.sub.2 -piperidine; 2.42 m, (6H), 3.times.CH.sub.2 --N; 3.36, br, (1H), CH--O; 4.08 m, (3H), 1--CH.sub.2, OH; 5.2, br, (2H), NH.sub.2 ; 7.30 m (1H), pyridine-5'; 7.92 m, 4', 8.62 m (1H), 6', 8.88 m, (1H), 2'.Type: GrantFiled: February 19, 1993Date of Patent: January 11, 1994Assignee: Chinoin Gyogyszar es Vegyeszeti Termekek Gyara RT.Inventors: Bela Bertok, Istvan Szekely, Angelika Thurna, Lajos Nagy, Eva Somfai, Sandor Botar, Antal Gajary, Kalman Takacs
-
Patent number: 5239077Abstract: The inventions is a purer form of O-(2-hydroxy-3-piperidino-1-propyl)nicotinic acid amidoxime hydrochloride.Type: GrantFiled: November 9, 1990Date of Patent: August 24, 1993Assignee: Chinoin Gyogyszar es Vegyeszeti Termekek Gyara Rt.Inventors: Bela Bertok, Istvan Szekely, Angelika Thurna, Lajos Nagy, Eva Somfai, Sandor Bota, Antal Gajary, Kalman Takacs
-
Patent number: 5153349Abstract: The invention relates to a process for the preparation of such isomer mixtures of cypermethrine of the Formula (I) ##STR1## wherein carbon atoms indicated by 1, 3 and .alpha. stand for a chiral carbon atom and the wavy line indicates cis or trans configuration related to the cyclopropane ring--which contains out of the theoretically possible 8-isomers of cypermethrine at least 95% of 1RtransS and 1StransR (Ib) isomer pair or only a mixture of 1RcisC and 1ScisR (Ia) and the isomer pair (Ib) of the ratio (Ia):(Ib)=55:45-25:75 by asymmetric transformation of second order performed in the presence of an amine base and solvent from a starting cypermethrine isomer mixture which contains next to the isomer pair (Ib) cis and other trans isomers or the isomer pair Ia+Ib at an undesired ratio.Type: GrantFiled: October 19, 1990Date of Patent: October 6, 1992Assignee: Chinoin Gyogyszer- es Vegyeszeti Termekek Gyara Rt.Inventors: Sandor Zoltan, Gyorgy Hidasi, Bela Bertok, Istavan Szekely, Janis Hajimichael, Sandor Botar, Lajos Nagy, Eva Somfai, Istvan Lak, Andras Rapi, Antal Gajary, Agnes Hegedus, Maria Tary
-
Patent number: 5043163Abstract: The present invention relates to a multi-component pesticidal composition against anthropoda containing as active ingredient pyrethroides and phosphate esters and optionally piperonyl butoxide and excipients comprising as pyrethroid component 0.1 to 40 percent by weight of cypermethrin related to the total weight comprising out of the 8 possible isomers 40 to 100 percent by weight of 1RcisS and/or 1RtransS stereoisomer and as a second component at least one phosphoric acid, thiophosphoric acid or dithiophosphate being toxic on arthropoda at a ratio of 1:1-99 related to the amount of cypermethrin.Type: GrantFiled: August 9, 1990Date of Patent: August 27, 1991Assignee: Chinoin Gyogyszer- es Vegyeszeti Termekek Gyara Rt.Inventors: Laszlo Pap, Eva Somfai, Andras Szego, Istvan Szekely, Lajos Nagy, Gyorgy Hidasi, Sandor Zoltan, Andrea Toth, Bela Bertok, Sandor Botar, Antal Gajary, Agnes Hegedus, Aniko Deak
-
Patent number: 4950682Abstract: The present invention relates to synergistic arthropodicidal composition of several pyrethroidal active ingredients causing no damage to warm-blooded organisms comprising pyrethroides and piperonyl butoxide as active ingredient which comprises as pyrethroidal active ingredient 0.1-20% by weight of 1StransR-alpha-cyano-3-phenoxy-benzyl-3- (2,2-dichlorvinyl)-2,2-dimethyl/cyclopropane-cyrboxylate of the Formula I ##STR1## 0.05-10% by weight of cis-trans-tetramethrin (3,4,5,6-tetrahydrophthalimido-methyl(1RS)-cis-trans-chrysantemate) or trans-tetramethrin of the Formula II ##STR2## and a further pyrethroide, 0.Type: GrantFiled: February 6, 1989Date of Patent: August 21, 1990Assignee: Chinoin Gyogyszer- es Vegyeszeti Termekek Gyara Rt.Inventors: Laszlo Pap, Peter Sarkozi, Eva Somfai, Andras Szego, Istvan Szekely, Gyorgy Hidasi, Sandor Zoltan, Aniko Deak nee Moinar, Agnes Hegedus, Bela Bertok, Sandor Botar, Antal Gajary, Lajos Nagy
-
Patent number: 4843174Abstract: The invention relates to the separation of the geometrical isomers of cyclopropane carboxylic acids of formula (I) ##STR1## wherein R represents alkyl having 1 to 4 carbon atoms or halogen.Type: GrantFiled: September 26, 1986Date of Patent: June 27, 1989Assignee: Chinoin Gyogyszer Es Vegyeszeti Temekek Gyara RtInventors: Gyula Balogh, Iren Boros neee Gundar, Antal Gajary, Gyorgy Hidasi, Andras Rappi, Jozsef Rakoczi, Rudolf Soos, Istvan Szekely, Sandor Zoltan
-
Patent number: 4638002Abstract: The invention relates to new 2,3,4-trinor-1,5-inter-m-phenylene-PGI.sub.2 derivatives of the formula (I) ##STR1## wherein A stands for carboxy, cyano, tetrazolyl or --COOR.sup.3 or --CONR.sup.1 R.sup.2 ;R.sup.3 is C.sub.1-4 alkyl or an equivalent of a pharmacologically acceptable cation:R.sup.1 and R.sup.2 each stands for hydrogen, phenyl; C.sub.1-5 alkyl, optionally substituted by carboxy, hydroxy, phenyl or C.sub.2-5 alkoxycarbonyl; or C.sub.1-4 alkylsulfonyl; orR.sup.1 and R.sup.2 together form an .alpha.,.omega.-alkylene chain containing 3-6 carbon atoms;B stands for oxygen or methylene;Y is optionally bromo-substituted vinylene or a --C.tbd.C-- group:R.sup.4 stands for hydrogen or tetrahydro-pyran-2-yl;R.sup.5 represents an alkyl group containing 5-9 carbon atoms, which can be optionally interrupted by one or more oxygen atom(s) or --CH.dbd.CH-- or --C.tbd.Type: GrantFiled: December 30, 1983Date of Patent: January 20, 1987Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Istvan Szekely, Sandor Botar, Krisztina Dolgos nee Kekesi, Bela Bertok, Antal Gajary, Tamas Szabolcsi, Gabor Kovacs, Marianna Lovasz nee Gaspar
-
Patent number: 4065491Abstract: The invention relates to a new and improved method for the preparation of N-phosphonomethyl-glycine, a potent pre-emergence herbicide. According to the invention glycine, formaldehyde and a dialkyl phosphite are condensed in an aqueous alkaline medium to form a N-phosphonomethyl-glycine dialkyl ester, and the diester is hydrolyzed with a mineral acid.Type: GrantFiled: January 12, 1977Date of Patent: December 27, 1977Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Todor Pfliegel, Jeno Seres, Antal Gajary, Klara Daroczy nee Csuka, Lajos T. Nagy