Abstract: There is provided a method for self-optimizing a system implementing a process. The method uses a computing arrangement including a processing arrangement and data memory coupled thereto. The computing arrangement includes an output interface for interrogating the system, and an input interface and for receiving measurement responses from the system. The computing arrangement includes a mathematical model of the system to be self-optimized. The method includes using the computing arrangement to configure interrogating data for interrogating the system, and to apply the interrogating data to the system via the output interface. The method further includes using the computing arrangement to collect corresponding measurement response data from the system via the input interface. The method includes using the computing arrangement to compute from the measurement response data one or more measured indicators representing operation of the system.