Abstract: An apparatus useful in immunoassay of a fluid, light is directed to an optical sensor wherein the light is transmitted to a replaceable optical device that is responsive to index of refraction in a sensing region thereof that is exposed to the fluid. One portion of the light is transmitted via a compensation path that includes the sensing region to a first detector. Another portion of the light is transmitted via a sensing path that includes the sensing region to another detector. In one embodiment a ratioing device receives an output from each detector and provides a signal responsive to the ratio of the outputs. The replaceable optical device typically comprises a pair of channel waveguides in directional coupling arrangement, or a pair of channel waveguides in an interferometer arrangement, or a ridge waveguide having a curved or serpentine path configured so that nonspecific sensing effects are compensated.

Abstract: A distributed fiber-optic sensor is obtained by using cladding that produces a change in the intensity of scattered light in the cladding of an optical fiber in response to a change in the environment of the cladding. The change in clad scattered light is coupled into the core causing a change in the intensity of backscattered light in the core. A sensing means such as an optical time domain refractometer is used to determine the change in intensity of the core backscattered light at a specific location along the fiber. The change in intensity of the scattered light in the clad is caused by overall changes in the amount of light in the cladding and changes in the number, size or both of the refractive index inhomogeneities in the cladding. These inhomogeneities can be, but are not limited to, composition variations, density variations of the same composition, phase separations, voids, or particulate inclusions.

Abstract: In apparatus useful in immunoassay of a fluid, light is directed to an optical sensor wherein the light is transmitted to a replaceable optical device that is responsive to index of refraction in a sensing region thereof that is exposed to the fluid. One portion of the light is transmitted via a reference path to a first detector. Another portion of the light is transmitted via a sensing path that includes the sensing region to another detector. A ratioing device receives an output from each detector and provides a signal responsive to the ratio of the outputs. The replaceable optical device typically comprises a pair of channel waveguides in directional coupling arrangement, or a pair of channel waveguides in an interferometer arrangement, or a ridge waveguide having a serpentine path.

Abstract: This invention relates to a device and a method for measuring the specific gravity of liquids, in particular, urine. This invention more particularly concerns a component of an automated system for urinalysis, either of humans or animals. The device may also be developed as a stand-alone unit and includes a dispenser, a sample container in which the liquid is dispensed and flushed, and a fiber optic sensor system to record the refractive index of the liquid. The invention is particularly suited for use with small clinical samples.

Abstract: A waveguide, approximately Y-shaped in plan view, provides coupling between first and second optical fibers, each attached to an end of the waveguide on the branched portion of the Y, and a third fiber attached to the single end of the Y. A fourth fiber, smaller in cross section than the waveguide on the single-ended portion of the Y and placed with its adjacent end therein between the junction of the Y and the third fiber, and bent gradually to one side, extends away from the waveguide before reaching the end to which the third fiber is attached. Typically the first fiber directs light from an emitter into the waveguide, the second fiber directs light away from the waveguide to a detector, the third fiber directs light away from the waveguide to a reference detector, and the fourth fiber directs light away from the waveguide to a sensor and back from the sensor into the waveguide.

Abstract: Blood gases and the like are monitored by a single probe having multiple dye wells and dyes immobilized in the wells, the dyes being exposed to the blood gases. Optical fibers and waveguides connected to the dye wells permit light to be directed from a light source to be dyes and the light due to absorption or the spontaneous emission of the dye returned to a light detector. The intensity, phase shift or other mechanism of the returned radiation is a measure of the partial pressure of a respective blood gas.

Abstract: Skin is removed from an edible material by passing the edible material through a skin removal zone of an ablative removal apparatus. In the skin removal zone, skin is ablatively removed by the action of a continuous wave carbon dioxide laser beam which rapidly traverses the skin removal zone in a direction substantially transverse to the edible material movement. The edible material may be skinned regardless of whether it is fresh, frozen, thawed, or cooked. Skin vaporized by the laser light beam generates a gaseous plume which is removed from the skin removal zone by causing a current of air to traverse that zone.

Abstract: Blood gases and the like are monitored by a single probe having multiple dye wells and dyes immobilized in the wells, the dyes being exposed to the blood gases. Optical fibers and waveguides connected to the dye wells permit light to be directed from a light source to the dyes and the light due to absorption or the spontaneous emission of the dye returned to a light detector. The intensity, phase shift or other mechanism of the returned radiation is a measure of the partial pressure of a respective blood gas.

Abstract: An aspirator/nebulizer for use in inhalation therapy has dual oxygen nozzles extending into a cylindrical chamber into which air can be aspirated in a controlled manner via closable air holes. A 50 psig oxygen source can be diluted to atmospheric air to yield an oxygen/air mixture comprising less than 30% oxygen at the conventional patient flow rates of 30-60 liters per minute. The dual oxygen nozzles also allow pure oxygen to be delivered at rates of at least 40 liters per minute when such high flow rates of relatively pure oxygen are needed for short term therapy.

Abstract: A nebulizer for use in connection with a lung ventilating system characterized in providing a dual stage atomization of medicament carrying liquid. A first stage develops an aerosol exhibiting an initial, relatively larger average liquid particle size which is introduced to a chamber at a given stagnation pressure. From that chamber, a second atomization is carried out by passing the gas entrained liquid particles through a knife edge orifice to produce a rapid expansion free-jet flow and consequent particle breakdown to achieve a desired particle size distribution.