Abstract: This invention relates to systems and methods for evaluating the differentiality of a set of discrete random variables between two or more conditions, such as a malignant condition responding to treatment regime and one that is not. It also provides for the identification and selection of drugs that act in coordinated manner to phenocopy a genetic network of a malignant condition that responds to at least an immune checkpoint blockade agent.

Abstract: The present invention provides a method that at least promotes, drives or directs a non-responsive neoplastic microenvironment towards a responsive phenotype. More particularly, the invention provides a method for enhancing the sensitivity of one or more neoplastic tumour to check point blockade agents. The present invention also provides a method for predicting response to immune checkpoint blockade.

Abstract: A lighting system is employed in a motor vehicle that includes a vehicle body arranged along a longitudinal axis and having a first vehicle body end configured to face oncoming ambient airflow when the vehicle is in motion relative to a road surface. The vehicle also includes a second vehicle body end opposing the first vehicle body end, and an aerodynamic-element having an aerodynamic-element body mounted to the second vehicle body end and arranged perpendicular to the longitudinal axis. The lighting system includes a light source mounted to the vehicle body and configured to direct at least one beam of light at the aerodynamic-element body. The lighting system also includes a light-reflecting feature arranged on the aerodynamic-element body and having an orientation configured to reflect the at least one beam of light along the longitudinal axis in a direction away from the first vehicle body end.

Abstract: A vehicle includes a body with an underbody portion having an outer periphery. At least one traction wheel is rotatably coupled to the body. The traction wheel has a track width defined by an inboard plane and an outboard plane. A movable panel with an inboard edge and an outboard edge is coupled to the underbody portion. An actuator is coupled to the movable panel and configured to actuate the movable panel between a stowed position and a deployed position. In the deployed position the outboard edge projects outboard of the outboard plane of the track width, and in the stowed position the outboard edge is retracted within the outer periphery of the underbody portion. A controller is configured to, in response to an operating condition being satisfied during a drive cycle, control the actuator to actuate the movable panel from the stowed position to the deployed position.

Abstract: A vehicle includes a body with an underbody portion having an outer periphery. At least one traction wheel is rotatably coupled to the body. The traction wheel has a track width defined by an inboard plane and an outboard plane. A movable panel with an inboard edge and an outboard edge is coupled to the underbody portion. An actuator is coupled to the movable panel and configured to actuate the movable panel between a stowed position and a deployed position. In the deployed position the outboard edge projects outboard of the outboard plane of the track width, and in the stowed position the outboard edge is retracted within the outer periphery of the underbody portion. A controller is configured to, in response to an operating condition being satisfied during a drive cycle, control the actuator to actuate the movable panel from the stowed position to the deployed position.

Abstract: A lighting system is employed in a motor vehicle that includes a vehicle body arranged along a longitudinal axis and having a first vehicle body end configured to face oncoming ambient airflow when the vehicle is in motion relative to a road surface. The vehicle also includes a second vehicle body end opposing the first vehicle body end, and an aerodynamic-element having an aerodynamic-element body mounted to the second vehicle body end and arranged perpendicular to the longitudinal axis. The lighting system includes a light source mounted to the vehicle body and configured to direct at least one beam of light at the aerodynamic-element body. The lighting system also includes a light-reflecting feature arranged on the aerodynamic-element body and having an orientation configured to reflect the at least one beam of light along the longitudinal axis in a direction away from the first vehicle body end.

Abstract: A tonneau cover system for a truck bed according to the present disclosure includes at least one tonneau panel configured to couple to a truck bed. The panel has a generally planar body with an exterior side and an interior side. The system additionally includes a generally planar movable flap coupled to the interior side. The movable flap is movable between a stowed position and a deployed position. In the stowed position the flap is disposed proximate and coplanar with the panel body, and in the deployed position the flap extends generally orthogonal from the body. The system additionally includes retention mechanism configured to selectively retain the flap in the deployed position or the stowed position.

Abstract: A system for controlling a sound level of a prime mover permitted to emanate from or within a vehicle includes a global positioning satellite (GPS) receiver operable for receiving a GPS signal and a sound control device. The sound control device is operable for increasing or decreasing a sound level of the prime mover in response to a control signal. A controller in communication with the GPS receiver includes a calendar and clock, and is programmed to execute a method, including receiving the GPS signal via the GPS receiver, and determining an actual location of the vehicle using the GPS signal. The controller also determines an actual date and time of day using the calendar and the clock, respectively, and transmits the control signal to the sound control device to increase or decrease the sound level using at least one of the actual location, date, and time of day.

Abstract: A system for controlling a sound level of a prime mover permitted to emanate from or within a vehicle includes a global positioning satellite (GPS) receiver operable for receiving a GPS signal and a sound control device. The sound control device is operable for increasing or decreasing a sound level of the prime mover in response to a control signal. A controller in communication with the GPS receiver includes a calendar and clock, and is programmed to execute a method, including receiving the GPS signal via the GPS receiver, and determining an actual location of the vehicle using the GPS signal. The controller also determines an actual date and time of day using the calendar and the clock, respectively, and transmits the control signal to the sound control device to increase or decrease the sound level using at least one of the actual location, date, and time of day.

Abstract: This invention relates to systems and methods for evaluating the differentiality of a set of discrete random variables between two or more conditions, such as a malignant condition responding to treatment regime and one that is not. It also provides for the identification and selection of drugs that act in coordinated manner to phenocopy a genetic network of a malignant condition that responds to at least an immune checkpoint blockade agent.

Abstract: A power cut off device includes a case and an actuator disposed in the case. The actuator includes a driver movable relative to the case. Specifically, the driver can move relative to the case between a first driver position and a second driver position. The power cut off device also includes a cutter defining a conductor receiving opening. The cutter is movably disposed in the case. Consequently, the cutter can move relative to the case between a first cutter position and a second cutter position. The cutter is operatively coupled to the actuator such that the driver is configured to drive the cutter from the first cutter position to the second cutter position when the driver moves from the first driver position to the second driver position in order to cut an electrical conductor disposed in the conductor receiving opening.

Abstract: A removable roof panel for a vehicle body having a compartment includes an outer panel, a perimeter frame connected to the outer panel and having a first locator feature configured to engage a second locator feature of the compartment, and latching handles operatively connected to the perimeter frame, and operable for latching and unlatching the perimeter frame from the vehicle body. The roof panel includes a lamp connected to the perimeter frame proximate the first locator feature, a battery electrically connectable to and operable for energizing the lamp, and a lamp actuator. The lamp actuator is configured to selectively connect the lamp to the battery when the removable roof panel is removed from the vehicle body to thereby illuminate the first and second locator features during stowing of the removable roof panel in the compartment. A vehicle includes the vehicle body and the removable roof panel.

Abstract: A power cut off device includes a case and an actuator disposed in the case. The actuator includes a driver movable relative to the case. Specifically, the driver can move relative to the case between a first driver position and a second driver position. The power cut off device also includes a cutter defining a conductor receiving opening. The cutter is movably disposed in the case. Consequently, the cutter can move relative to the case between a first cutter position and a second cutter position. The cutter is operatively coupled to the actuator such that the driver is configured to drive the cutter from the first cutter position to the second cutter position when the driver moves from the first driver position to the second driver position in order to cut an electrical conductor disposed in the conductor receiving opening.

Abstract: A flow drill screw can retain a structure and includes a shank extending along a longitudinal axis. The shank includes a first shank end and a second shank end opposite the first shank end. The flow drill screw further includes a pointed tip coupled to the first shank end. The pointed tip includes at least one facet. The flow drill screw also includes a stud extending from the shank along the longitudinal axis and away from the first shank end. The stud includes a first stud end and a second stud end opposite the first stud end. Further, the stud includes external threads between the first and second stud ends. The flow drill screw includes an annular flange coupled to the second shank end and the first stud end. Moreover, the flow drill screw includes a head coupled to the second stud end.

Abstract: A flow drill screw can retain a structure and includes a shank extending along a longitudinal axis. The shank includes a first shank end and a second shank end opposite the first shank end. The flow drill screw further includes a pointed tip coupled to the first shank end. The pointed tip includes at least one facet. The flow drill screw also includes a stud extending from the shank along the longitudinal axis and away from the first shank end. The stud includes a first stud end and a second stud end opposite the first stud end. Further, the stud includes external threads between the first and second stud ends. The flow drill screw includes an annular flange coupled to the second shank end and the first stud end. Moreover, the flow drill screw includes a head coupled to the second stud end.

Abstract: An inside rearview mirror assembly can hold a tag, such as a parking tag. The inside rearview mirror assembly includes a mirror and a housing. The housing is coupled to the mirror and includes a housing body and a holder protruding from the housing body in a direction away from the mirror. The holder includes a holder body and defines a groove disposed along the holder body. The groove is configured to receive the tag.

Abstract: The present invention relates to agents capable of treating or preventing an allergic disorder in an animal and a method of screening for these agents. In particular, the present invention relates to an isolated nucleic acid molecule comprising (a) an isolated nucleic acid molecule whose expression is modulated in a mammal suffering from or at elevated risk of developing an allergic condition, such that the level of expression of the nucleic acid differs from that in a mammal which is not suffering from or at elevated risk of developing the allergic condition, in which the nucleic acid comprises a sequence selected from the group consisting of sequences identified by probes 243610 at on human chromosome 9q21.13 at locus 138255, 1556097 at on human chromosome 15q25.2 and 242743 at on human chromosome 16p12.

Abstract: The present invention relates to genes whose level of expression is different in allergic animals compared with non-allergic animals. In particular, the present invention relates to a method for predicting the development of an allergic disorder in a mammal by determining the gene expression pattern of a panel of specific sequences comprising CAMK2D and CDH1 within a nucleic acid pool that have been predetermined to either increase or decrease in response to allergy.

Abstract: The present invention relates to methods for diagnosing an allergic disorder, predicting the development of an allergic disorder in an animal, monitoring the progress of therapy targeted at an allergic disorder, classification of the allergic disorder into one or more clinical/immunological phenotypes, and/or determining the potentional responsiveness of individual animals suffering from or at risk of an allergic disorder to particular forms of therapy. In particular, the present invention relates to a method of diagnosing and/or predicting the development of an allergic disorder in an animal, comprising the step of analysing a biological sample from the animal to determine the level of activation of one or more allergy-associated genes, in which the level of activation is diagnostic of the allergic disorder or predicative of the relative risk for the development of an allergic disorder in the animal.