Abstract: A suturing device for suturing a portion of biological tissue includes a needle attached to a suture, a needle holder that releasably holds the needle, and a needle driver adapted to be advanced and retracted substantially parallel to a longitudinal axis of the suturing device. A distal needle holder adapted to releasably hold the needle is positioned in a distal position relative to the portion of biological tissue and a distal end of the needle driver is positioned in a proximal position relative to the portion of biological tissue. The needle is positioned in either the proximal position or the distal position. The needle driver is moved longitudinally in a first direction along a path substantially parallel to the longitudinal axis such that the needle and suture pass through the portion of biological tissue, thereby forming a suture incision through which the suture passes. By repeating the above-described processes, a series of stitches is thereby formed.

Abstract: Disclosed herein are embodiments of devices, systems and methods for suturing biological tissue incorporating one or more suture spools. The suture spools can be located external to a handle or elongate body of a suturing device, and can contain the sutures within an inner circumference of the suture spools. The suture spools can be configured to reduce entanglement of sutures during use in an operation.

Abstract: Methods and apparatuses are disclosed for closing a patent foramen ovale. Some of the disclosed apparatuses include an elongate body having a proximal end and a distal end, with first and second suture clasp arms adapted to hold end portions of a suture when in an extended position. A first suture catch mechanism is slidably housed in the elongate body and moves in a proximal-to-distal direction to engage the suture end held by the first suture clasp arm, and a second suture catch mechanism is slidably housed in the elongate body and moves in a distal-to-proximal direction to suture end held by the second suture clasp arm. The first suture clasp arm can be positioned around the septum primum to deliver a suture thereto, and the second suture clasp arm can be positioned around the septum secundum to deliver a suture thereto.

Abstract: Constriction valves for catheters and method of using constriction valves are presented. The catheter valve has a conduit defining a lumen. The catheter also has a spring that is configured to bias the lumen from an open position to a closed position by altering an effective length of the conduit or altering the circumference of the conduit. The spring is further configured to change its configuration by changes of intraluminal pressure of the valve. A user can insert a tool into a catheter having a valve by manipulating the valve to expand a substantially closed lumen by compressing the spring, twisting the spring, or pulling on a cord coupled with the valve.

Abstract: Disclosed herein are embodiments of devices and methods for forming a seal covering an incision in tissue. In some embodiments, a deformable member can be loaded into a catheter and inserted into the tissue incision. The deformable member can unfold into a cup-shape which can form a seal around the incision during a procedure. Once the procedure is finished, the deformable member can be drawn back into the tube.

Abstract: A suturing device uses an inflatable balloon coupled to multiple arms and needles to place sutures at appropriate positions. In preferred embodiments the suturing device includes an elongated body having a working end, a controlling end, and a lumen. The elongated body is coupled to an arm having a distal end with a needle target, which is used to place a suture in an appropriate position relative to the aperture. An inflatable balloon is positioned in an area enclosed by the arm, such that inflating the balloon physically moves a needle towards the needle target.

Abstract: A suture tensioning device that deters over-tensioning or under-tensioning of suture thread(s) is presented. The suture tensioning device includes an engagement portion and a tensioning portion. Optionally, the suture tensioning device also includes a detent portion. The tensioning portion has a tension limiter, which can be a protrusion, a wheel with a clutching mechanism, a spring, etc. A suture can be immobilized in the engagement portion of the suture tensioning device, and the tension can be increased or decreased by moving the tensioning portion. The tension limiter limits the movements of the tensioning portion so that the tension of the suture(s) can be set to a desirable level.

Abstract: A knot placement device allows a physician to apply a knot for securing two or more suture ends extending from an incision in a vessel or organ of a patient relative to each other in order to seal an opening in the vessel or organ. The knot placement device has a handle and an elongate shaft and a push rod slidably inserted in said shaft. A knot is disposed in the distal end of the shaft. An actuator on the handle may be depressed to distally advance said push rod relative to said shaft and thereby distally advance said knot. The knot may include a knot body having an inner cavity and a plug sized to fit securely within the inner cavity. In use, the plug may be inserted into the inner cavity of the knot body to fixedly hold two or more suture ends between the knot body and the plug.

Abstract: Suturing devices and systems used to close openings into a biological structure. The suturing device can comprise an elongate member having a proximal end, a distal end, one or more arms, and one or more needles. One or more sheaths may be used with the device to maintain or substantially maintain haemostasis while the device is used and while a procedure is performed in the biological structure.

Abstract: Suturing apparatuses configured to suture biological tissue, such as an anatomical valve. The suturing apparatuses can comprise an elongate member having a proximal end, a distal end, one or more arms, and one or more needles. A protective member may be used to inhibit contact between a distal end of a needle and surrounding tissue. Methods for suturing bodily tissue such as an anatomical valve may be performed with the suturing apparatuses. The suturing apparatuses may be used to suture adjacent valve leaflets or the base of a valve in order to treat or repair the valve.

Abstract: Suturing apparatuses configured to suture biological tissue, such as an anatomical valve. The suturing apparatuses can comprise an elongate member having a proximal end, a distal end, one or more arms, and one or more needles. A protective member may be used to inhibit contact between a distal end of a needle and surrounding tissue. Methods for suturing bodily tissue such as an anatomical valve may be performed with the suturing apparatuses. The suturing apparatuses may be used to suture adjacent valve leaflets or the base of a valve in order to treat or repair the valve.

Abstract: Suturing devices and systems used to close openings into a biological structure. The suturing device can comprise an elongate member having a proximal end, a distal end, one or more arms, and one or more needles. One or more sheaths may be used with the device to maintain or substantially maintain haemostasis while the device is used and while a procedure is performed in the biological structure.

Abstract: A suturing instrument using a curved needle is presented. The suturing instrument includes an elongated body, which has a lumen at its distal end. The suturing device also includes a curved needle which has a hook at its distal end to capture a suture from a suture staging area coupled with the suture. The rotational movement of the curved needle can be operated by a linear movement of a controlling element via a compound pivots that are configured to move the needles out from the lumen, couple the needle to the suture, and pull the suture away back toward the lumen.

Abstract: A suture device with a holding block, and methods of controlling relative positions of ends of multiple suture needles in the suture device, are presented. The suture device has two or more suture needles, and a guide wire, all of which are coupled to the holding block. Suture needles are affixed at the holding block at two distinct contact regions and the guide wire is disposed at the holding block in a slidable relationship. By affixing two needles at the holding block, the relative positions of ends of suture needles can be maintained in the suture device, so that two needles can capture sutures simultaneously, even when two needles are curved in opposite directions.

Abstract: A suturing device, and methods for suturing various sizes of apertures in tissues, are presented. The suturing device has a body with at least one or more adjustable arms that are coupled with catch targets. The arms are coupled with needle guides such that movements of the arms orient the needle guides to direct the needles towards the catch targets. The catch targets are coupled with sutures, such that when the needles reach the targets, they capture and pull the sutures back to the body. By changing the angles at which the arms extend from the body, the catch targets are moved closer to, or farther from, the body, and the suture device is readily configured to suture various sizes of apertures.

Abstract: Constriction valves for catheters and method of using constriction valves are presented. The catheter valve has a conduit defining a lumen. The catheter also has a spring that is configured to bias the lumen from an open position to a closed position by altering an effective length of the conduit or altering the circumference of the conduit. The spring is further configured to change its configuration by changes of intraluminal pressure of the valve. A user can insert a tool into a catheter having a valve by manipulating the valve to expand a substantially closed lumen by compressing the spring, twisting the spring, or pulling on a cord coupled with the valve.

Abstract: A suturing instrument using a curved needle is presented. The suturing instrument includes an elongated body, which has a lumen at its distal end. The suturing device also includes a curved needle which has a hook at its distal end to capture a suture from a suture staging area coupled with the suture. The rotational movement of the curved needle can be operated by a linear movement of a controlling element via a compound pivots that are configured to move the needles out from the lumen, couple the needle to the suture, and pull the suture away back toward the lumen.

Abstract: Suturing apparatuses configured to suture biological tissue, such as an anatomical valve, can include an elongate member having a proximal end, a distal end, one or more arms, and one or more needles. A protective member may be used to inhibit contact between a distal end of a needle and surrounding tissue. Methods for suturing bodily tissue such as an anatomical valve may be performed with the suturing apparatuses. The suturing apparatuses may be used to suture adjacent valve leaflets or the base of a valve in order to treat or repair the valve.

Abstract: A knot placement device allows a physician to apply a knot for securing two or more suture ends extending from an incision in a vessel or organ of a patient relative to each other in order to seal an opening in the vessel or organ. The knot placement device has a handle and an elongate shaft and a push rod slidably inserted in said shaft. A knot is disposed in the distal end of the shaft. An actuator on the handle may be depressed to distally advance said push rod relative to said shaft and thereby distally advance said knot. The knot may include a knot body having an inner cavity and a plug sized to fit securely within the inner cavity. In use, the plug may be inserted into the inner cavity of the knot body to fixedly hold two or more suture ends between the knot body and the plug.

Abstract: A suturing device for suturing a portion of biological tissue includes a needle attached to a suture, a needle holder that releasably holds the needle, and a needle driver adapted to be advanced and retracted substantially parallel to a longitudinal axis of the suturing device. A distal needle holder adapted to releasably hold the needle is positioned in a distal position relative to the portion of biological tissue and a distal end of the needle driver is positioned in a proximal position relative to the portion of biological tissue. The needle is positioned in either the proximal position or the distal position. The needle driver is moved longitudinally in a first direction along a path substantially parallel to the longitudinal axis such that the needle and suture pass through the portion of biological tissue, thereby forming a suture incision through which the suture passes. By repeating the above-described processes, a series of stitches is thereby formed.