Patents by Inventor Anthony A. Sauve
Anthony A. Sauve has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12274679Abstract: Provided herein are compounds (e.g., compounds of Formula (I) and Formula (II), that modulate HCN channels, intermembrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HCN-related disorders (e.g., pain) with the compounds in a subject, by administering the compounds and/or compositions described herein.Type: GrantFiled: April 26, 2023Date of Patent: April 15, 2025Assignee: Cornell UniversityInventors: Gareth R. Tibbs, Peter A. Goldstein, Anthony A. Sauve, Rajendra Uprety, James David Warren, Jr., Rebecca L. Joyce, Dipti N. Barman
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Publication number: 20240366529Abstract: Provided herein are compounds (e.g., compounds of Formula (I) and Formula (II), that modulate HCN channels, intermembrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HCN-related disorders (e.g., pain) with the compounds in a subject, by administering the compounds and/or compositions described herein.Type: ApplicationFiled: April 26, 2023Publication date: November 7, 2024Applicant: Cornell UniversityInventors: Gareth R. Tibbs, Peter A. Goldstein, Anthony A. Sauve, Rajendra Uprety, James David Warren, JR., Rebecca L. Joyce, Dipti N. Barman
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Patent number: 11684590Abstract: Provided herein are compounds (e.g., compounds of Formula (I) and Formula (II), that modulate HCN channels, intermembrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HCN-related disorders (e.g., pain) with the compounds in a subject, by administering the compounds and/or compositions described herein.Type: GrantFiled: June 27, 2019Date of Patent: June 27, 2023Assignee: Cornell UniversityInventors: Gareth R. Tibbs, Peter A. Goldstein, Anthony A. Sauve, Rajendra Uprety, James David Warren, Jr., Rebecca L. Joyce, Dipti N. Barman
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Patent number: 11633414Abstract: The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.Type: GrantFiled: July 27, 2021Date of Patent: April 25, 2023Assignee: Cornell UniversityInventors: Anthony A. Sauve, Tianle Yang Redanz
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Patent number: 11530233Abstract: The invention provides a compound of formula (I): wherein R is as described herein. The invention also provides a process for the preparation of the compound.Type: GrantFiled: March 29, 2021Date of Patent: December 20, 2022Assignee: Cornell UniversityInventor: Anthony A. Sauve
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Publication number: 20210388018Abstract: The invention provides a compound of formula (I): (I) wherein R is methyl or ethyl. The invention also provides a process for the preparation of the compound. The invention further provides a method for increasing cell NAD+ production or improving mitochondrial densities in a cell, wherein the method comprises administering to the cell a compound or salt of the invention.Type: ApplicationFiled: October 1, 2019Publication date: December 16, 2021Applicant: Cornell UniversityInventor: Anthony A. Sauve
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Publication number: 20210353657Abstract: The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.Type: ApplicationFiled: July 27, 2021Publication date: November 18, 2021Applicant: Cornell UniversityInventors: Anthony A. Sauve, Tianle Yang Redanz
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Publication number: 20210267909Abstract: Provided herein are compounds (e.g., compounds of Formula (I) and Formula (II), that modulate HCN channels, intermembrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HCN-related disorders (e.g., pain) with the compounds in a subject, by administering the compounds and/or compositions described herein.Type: ApplicationFiled: June 27, 2019Publication date: September 2, 2021Applicant: Cornell UniversityInventors: Gareth R. Tibbs, Peter A. Goldstein, Anthony A. Sauve, Rajendra Uprety, James David Warren, Rebecca L. Joyce, Dipti N. Barman
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Patent number: 11077129Abstract: The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.Type: GrantFiled: May 29, 2020Date of Patent: August 3, 2021Assignee: Cornell UniversityInventors: Anthony A. Sauve, Tianle Yang Redanz
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Publication number: 20210214386Abstract: The invention provides a compound of formula (I): wherein R is as described herein. The invention also provides a process for the preparation of the compound.Type: ApplicationFiled: March 29, 2021Publication date: July 15, 2021Applicant: Cornell UniversityInventor: Anthony A. Sauve
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Patent number: 10961268Abstract: The invention provides a compound of formula (I): wherein R is as described herein. The invention also provides a process for the preparation of the compound.Type: GrantFiled: April 5, 2018Date of Patent: March 30, 2021Assignee: Cornell UniversityInventor: Anthony A. Sauve
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Publication number: 20200289535Abstract: The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.Type: ApplicationFiled: May 29, 2020Publication date: September 17, 2020Inventors: Anthony A. Sauve, Tianle Yang Redanz
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Patent number: 10668096Abstract: The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.Type: GrantFiled: February 15, 2019Date of Patent: June 2, 2020Assignee: CORNELL UNIVERSITYInventors: Anthony A. Sauve, Tianle Yang Redanz
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Publication number: 20200031860Abstract: The invention provides a compound of formula (I): wherein R is as described herein. The invention also provides a process for the preparation of the compound.Type: ApplicationFiled: April 5, 2018Publication date: January 30, 2020Applicant: Cornell UniversityInventor: Anthony A. Sauve
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Patent number: 10525070Abstract: Disclosed herein is a method for treating heart failure in a subject in need thereof. The method includes administering a therapeutically effective amount of nicotinamide riboside to the subject. The heart failure may be associated with iron deficiency. The method may also include administering iron to the subject.Type: GrantFiled: February 10, 2016Date of Patent: January 7, 2020Assignees: DUKE UNIVERSITY, CORNELL UNIVERSITYInventors: Nancy C. Andrews, Wenjing Xu, Anthony A. Sauve
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Publication number: 20190192542Abstract: The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.Type: ApplicationFiled: February 15, 2019Publication date: June 27, 2019Inventors: Anthony A. Sauve, Tianle Yang Redanz
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Patent number: 10206940Abstract: The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of snaking nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.Type: GrantFiled: April 25, 2016Date of Patent: February 19, 2019Assignee: CORNELL UNIVERSITYInventors: Anthony A. Sauve, Tianle Yang Redanz
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Publication number: 20190038647Abstract: Disclosed herein is a method for treating heart failure in a subject in need thereof. The method includes administering a therapeutically effective amount of nicotinamide riboside to the subject. The heart failure may be associated with iron deficiency. The method may also include administering iron to the subject.Type: ApplicationFiled: February 10, 2016Publication date: February 7, 2019Inventors: Nancy C. Andrews, Wenjing Xu, Anthony A. Sauve
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Patent number: 9790252Abstract: Disclosed are halogenated 2-deoxy-lactone, 2?-deoxy-nucleosides, and derivatives thereof, for example, a compound of formula (I). Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one compound or salt of the invention, and a method of treating a disorder is selected from the group consisting of an abnormal cellular proliferation, a viral infection, and an autoimmune disorder.Type: GrantFiled: July 1, 2010Date of Patent: October 17, 2017Assignee: CORNELL UNIVERSITYInventors: Anthony A. Sauve, Yana Cen
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Publication number: 20160310517Abstract: The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of snaking nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.Type: ApplicationFiled: April 25, 2016Publication date: October 27, 2016Inventors: Anthony A. Sauve, Tianle Yang Redanz