Patents by Inventor Anthony A. Sinkula

Anthony A. Sinkula has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds, compositions and methods of use
    Patent number: 4067995
    Abstract: It has now been discovered that novel compounds of FIG. 1 ##STR1## are useful in the prophylactic treatment of sensitized humans and animals for allergy and all anaphylactic reactions of a reagin or non-reagin mediated nature. Additionally, the compounds are intermediates to the diacid or di salts which have utility in the same area as the esters. The compounds are formulated with pharmaceutical carriers for oral, parenteral, inhalation, or rectal means of administration.
    Type: Grant
    Filed: November 28, 1975
    Date of Patent: January 10, 1978
    Assignee: The Upjohn Company
    Inventors: John B. Wright, Anthony A. Sinkula
  • Ibuprofen p-hydroxyphenylurea ester
    Patent number: 4049700
    Abstract: Ibuprofen p-hydroxyphenylurea ester having the formula II: ##STR1## was prepared from the free acid, ibuprofen [.+-.2-(p-isobutylphenyl)propionic acid](I).The ester II above has the anti-inflammatory activity of the free acid, but in contradistinction to it, it has a pleasant taste, suitable for oral administration such as uncoated tablets, suspensions or syrups, for the treatment of inflammatory conditions, particularly arthritis.
    Type: Grant
    Filed: June 17, 1976
    Date of Patent: September 20, 1977
    Assignee: The Upjohn Company
    Inventor: Anthony A. Sinkula
  • Ibuprofen p-hydroxybenzaldehyde semicarbazone ester
    Patent number: 4049699
    Abstract: Ibuprofen p-hydroxybenzaldehyde semicarbazone ester having the formula II: ##STR1## was prepared from the free acid, ibuprofen [.+-.2-(p-isobutylphenyl)propionic acid] (I).The ester II above has the anti-inflammatory activity of the free acid, but in contradistinction to it, it has a pleasant taste, suitable for oral administration such as uncoated tablets, suspensions or syrups, for the treatment of inflammatory conditions, particularly arthritis.
    Type: Grant
    Filed: June 17, 1976
    Date of Patent: September 20, 1977
    Assignee: The Upjohn Company
    Inventor: Anthony A. Sinkula
  • N,N"(pyridinediyl)dioxamate compounds
    Patent number: 3980660
    Abstract: It has now been discovered, that compounds of FIG. 1 ##SPC1##are useful in the prophylactic treatment of sensitized humans and animals for allergy and all anaphylactic reactions of a reagin or non-reagin mediated nature. Additionally, the compounds are intermediates to the biologically active dioxamic acids and their salts. The compounds are formulated with pharmaceutical carriers for oral, parenteral, inhalation or rectal means of administration.
    Type: Grant
    Filed: June 10, 1974
    Date of Patent: September 14, 1976
    Assignee: The Upjohn Company
    Inventors: John B. Wright, Charles M. Hall, Anthony A. Sinkula
  • Process for converting esters to amine salts
    Patent number: 3962308
    Abstract: A new method for converting certain diesters to physiologically acceptable amines which comprises reacting the diester with the desired amine in a solvent consisting essentially of water.
    Type: Grant
    Filed: August 28, 1974
    Date of Patent: June 8, 1976
    Assignee: The Upjohn Company
    Inventor: Anthony A. Sinkula