Abstract: Described are RNAi agents, compositions that include RNAi agents, and methods for inhibition of coronavirus (CoV) viral genome. The CoV RNAi agents and RNAi agent conjugates disclosed herein inhibit the expression of a SARS-CoV-2 viral genome, and the targeted portions of the genome are conserved across a variety of known coronaviruses. Pharmaceutical compositions that include one or more CoV RNAi agents, optionally with one or more additional therapeutics, are also described. Delivery of the described CoV RNAi agents to pulmonary cells, in vivo, provides for inhibition of CoV viral genome expression, including SARS-CoV-2, which can provide a therapeutic benefit to subjects, including human subjects, for the treatment of various diseases including COVID-19.

Abstract: The device takes the form of a strong-back which is attachable to a garbage can, generally vertically thereof, and has top and bottom handles for hoisting the can to the dumping position used by garbage truck drivers. The strong-back also has ground wheels so that the can can be converted to a hand truck. One of the handles is rotatable and positioned between the ground wheels so as to perform as a more stable intermediate wheel for going up and down stairs and the like.