Abstract: Disclosed herein, in certain aspects, are materials and methods for molecules comprising improved single chain variable fragments.

Abstract: Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions.

Abstract: Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions.

Abstract: Novel rodent bispecific heterodimeric proteins, such as rodent bispecific antibodies, in vitro method for producing such, and uses thereof.

Abstract: The present invention relates to engineered antibodies and other Fc-domain containing molecules with enhanced agonism and effector functions.

Abstract: Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions.

Abstract: A novel receptor for GDF15 was identified (GFRAL), as well as the use of this receptor in the identification or screening of GDF15 agonists or antagonists. These agonist or antagonist compounds may be used to either potentiate or suppress GDF15-like effects, respectively, at the cellular and organism levels, and may be used in treatment of metabolic diseases, including obesity, type 2 diabetes, hyperglycemia, hyperinsulinemia, dyslipidemia, diabetic nephropathy, or anorexia.

Abstract: Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions.

Abstract: The present invention relates to engineered antibodies and other Fc-domain containing molecules with enhanced agonism and effector functions.

Abstract: Novel rodent bispecific heterodimeric proteins, such as rodent bispecific antibodies, in vitro method for producing such, and uses thereof.

Abstract: Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions.

Abstract: A method and system for cleaning containers being transposed through a container cleaning line, including an open-ended housing, a predetermined container flow path defined by the line of moving containers traversing the enclosure defined by the housing longitudinally, a first set of ionizing air nozzles mounted within the housing for directing ionized compressed air toward the containers in the container flow path, with at least one of the nozzles directing air flow into an open side of each container as it passes the nozzle and a second set of high velocity air nozzles mounted within the housing for directing high velocity compressed air toward the container flow path, the second set of high velocity nozzles being disposed along a direction essentially parallel to the container flow path with at least one of the nozzles flows directing high velocity air flow into the open side of each container as it passes the nozzle. Nozzle guards are provided to prevent contact between the containers and the nozzles.

Abstract: In a computer system, a passive component minimization of connector pins configuration includes a motherboard and daughterboard. The daughterboard includes a selection switch coupled via passive components to a single connector pin, according to a prescribed state of multiple states of the daughterboard. In one embodiment, the passive components include three series connected resistors collectively coupled to the daughterboard connector pin. The motherboard includes a supply voltage and pull-up resistor circuit coupled to a single connector pin, and further includes decoding circuitry coupled to the motherboard connector pin for decoding a voltage level of the motherboard connector pin into binary data.

Abstract: In a computer system, a passive component minimization of connector pins configuration includes a motherboard and daughterboardd. The daughterboard includes a selection switch coupled via passive components to a single connector pin, according to a prescribed state of multiple states of the daughterboard. In one embodiment, the passive components include three series connected resistors collectively coupled to the daughterboard connector pin. The motherboard includes a supply voltage and pull-up resistor circuit coupled to a single connector pin, and further includes decoding circuitry coupled to the motherboard connector pin for decoding a voltage level of the motherboard connector pin into binary data.

Abstract: Use of a variable voltage supply to clamp a diode for shunting signal glitches is described. Clamping the diode to a variable voltage supply enables forward-biasing of the diode, thereby preparing the diode for the glitch and effectively reducing the diode's turn-on time. The voltage of the variable voltage supply is determined by the size of the clamping diode used and the magnitude of the glitch it is designed to shunt. In one embodiment, the variable voltage supply is a temperature compensated voltage supply, such that as the temperature, and hence, the capacitance, of the diode changes, the value of the variable voltage supply also changes accordingly.

Abstract: A computer system is disclosed which includes at least one microprocessor having an L2 cache, at least one memory, and basic input output system (BIOS) firmware. The L2 cache includes error checking and correcting capability (ECC). The at least one memory includes either all ECC capable memory or any combination of ECC capable and non-ECC capable memory. Lastly, the basic input output system (BIOS) firmware includes an L2 cache support feature. The L2 cache support feature includes three user-selectable options, the three options including i) L2 cache ECC ON, ii) L2 cache ECC OFF, and iii) L2 cache AUTO. Selection of L2 cache ECC ON is for enabling L2 cache ECC. Selection of L2 cache ECC OFF is for not enabling L2 cache ECC. Lastly, selection of L2 cache ECC AUTO is for automatically enabling or not enabling L2 cache ECC in response to a detection of the presence of a) all ECC capable memory or b) any combination of ECC and non-ECC capable memory, respectively.