Abstract: Various aspects of the disclosure relate to monitoring a physical location to determine and/or predict anomalous activities. One or more machine learning algorithms may be used to analyze inputs from one or more sensors, cameras, audio recording equipment, and/or any other types of sensors to detect anomalous measurements/patterns. Notifications may be sent one or more devices in a network based on the detection.

Abstract: Disclosed are materials and methods for improved single chain variable fragments.

Abstract: Disclosed are materials and methods for improved single chain variable fragments.

Abstract: Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions.

Abstract: Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions.

Abstract: Disclosed are materials and methods for improved single chain variable fragments.

Abstract: Novel rodent bispecific heterodimeric proteins, such as rodent bispecific antibodies, in vitro method for producing such, and uses thereof.

Abstract: The present invention relates to engineered antibodies and other Fc-domain containing molecules with enhanced agonism and effector functions.

Abstract: Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions.

Abstract: A novel receptor for GDF15 was identified (GFRAL), as well as the use of this receptor in the identification or screening of GDF15 agonists or antagonists. These agonist or antagonist compounds may be used to either potentiate or suppress GDF15-like effects, respectively, at the cellular and organism levels, and may be used in treatment of metabolic diseases, including obesity, type 2 diabetes, hyperglycemia, hyperinsulinemia, dyslipidemia, diabetic nephropathy, or anorexia.

Abstract: Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions.

Abstract: The present invention relates to engineered antibodies and other Fc-domain containing molecules with enhanced agonism and effector functions.

Abstract: Novel rodent bispecific heterodimeric proteins, such as rodent bispecific antibodies, in vitro method for producing such, and uses thereof.

Abstract: Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions.

Abstract: A vessel (30) comprising a hull (15) having an apparent centre of pitch (23) located at a position between about 10% and 35% of the length of the vessel (10) measured from the aftermost point (17) of the vessel on the design waterline. The hull (15) may be bare, or alternatively may be fitted with a damping system (31) located forwardly to provide damping forces to reduce the vertical motion at the bow and hence the vertical accelerations. In one arrangement, the vessel (10) may comprise a single hull vessel. In another arrangement, the vessel (10) may comprise a multi-hulled vessel.

Abstract: A vessel (10) comprising a hull (15) having a the Longitudinal Centre of Flotation (LCF) at the design load waterline (25) at rest with a value of less than about 35% of the vessel waterline length measured from the aftermost point (19) of the vessel waterline. The design vessel speed at design load waterline is at or above Froude Number of 0.45. The hull (15) has a length-to-beam ratio on the design waterline of greater than about 8.0. The Longitudinal Centre of Buoyancy (LCB) is between about 30% and 45% of the vessel waterline length measured from the aftermost point (19) of the vessel waterline (25). In one arrangement, the vessel (10) may comprise a single hull vessel. In another arrangement, the vessel (10) may comprise a multi-hulled vessel.

Abstract: A vessel (30) comprising a hull (15) having an apparent centre of pitch (23) located at a position between about 10% and 35% of the length of the vessel (10) measured from the aftermost point (17) of the vessel on the design waterline. The hull (15) may be bare, or alternatively may be fitted with a damping system (31) located forwardly to provide damping forces to reduce the vertical motion at the bow and hence the vertical accelerations. In one arrangement, the vessel (10) may comprise a single hull vessel. In another arrangement, the vessel (10) may comprise a multi-hulled vessel.

Abstract: A multi-hulled vessel (10) configured as a trimaran. The multi-hulled vessel (10) comprises a main hull (15) and at least one outer hull (17) to each side of the main hull, the main hull (15) and each side hull (17) adjacent thereto being interconnected by a bridge structure (19). The bridge structure (19) and the hulls (15, 17) connected thereby cooperating to provide a deck surface (21) adapted to carry a load. The main hull 15) is configured to define at least one engine room (45) below the deck surface (21) and trunking (70) for provision of services to the engine room. The trunking (70) is routed below the area of the deck surface (21) required for carrying a load. Because the trunking (70) is routed below the area of the deck surface (21) required for load-carrying, it does not extend through that area of the deck surface to impede load movements.

Abstract: A multi-hulled vessel (10) configured as a trimaran. The multi-hulled vessel (10) comprises a main hull (15) and at least one outer hull (17) to each side of the main hull. The multi-hulled vessel (10) is provided with motion control means (40) for providing damping to wave-induced motion, thereby offering ride control. The motion control means (40) comprises a forward motion damping device (41) disposed adjacent the bow (25) of the main hull (15), and two aft dampening devices (43) disposed one adjacent the stern (33) of each side hull (17). With this arrangement, one of the motion damping devices (41, 43) is located at or near each apex of a notional triangular envelope (44) of the vessel (10). Each motion damping device (41, 43) is configured to resist wave-induced motion of the multi-hulled vessel (10) and thereby provide a damping effect. Each motion damping device (41, 43) may comprise an underwater hydrofoil (45), although other damping arrangements are possible.

Abstract: A vessel (30) comprising a hull (15) having an apparent centre of pitch (23) located at a position between about 10% and 35% of the length of the vessel (10) measured from the aftermost point (17) of the vessel on the design waterline. The hull (15) may be bare, or alternatively may be fitted with a damping system (31) located forwardly to provide damping forces to reduce the vertical motion at the bow and hence the vertical accelerations. In one arrangement, the vessel (10) may comprise a single hull vessel. In another arrangement, the vessel (10) may comprise a multi-hulled vessel.