Abstract: A thermophilic micro-organism comprising a modification that increases amylase expression and starch hydrolysis compared to wild-type, wherein the modification is insertion of a heterologous amylase gene.

Abstract: A thermophilic micro-organism comprising a modification that increases amylase expression and starch hydrolysis compared to wild-type, wherein the modification is insertion of a heterologous amylase gene.

Abstract: A thermophilic micro-organism comprising a modification that increases amylase expression and starch hydrolysis compared to wild-type, wherein the modification is insertion of a heterologous amylase gene.

Abstract: A thermophilic microorganism comprising a modification that prevents sporulation, wherein the modification inactivates the native spo0A gene.

Abstract: A thermophilic micro-organism comprising a modification that increases amylase expression and starch hydrolysis compared to wild-type, wherein the modification is insertion of a heterologous amylase gene.

Abstract: Epoxidised oil, epoxidised wax or epoxidised fatty acid ester recovered from Vernonia Galamensis seeds provide topical medicament preparations which are effective in preventing and treating various different forms of skin diseases, skin lesions and wounds. These epoxidised oil, epoxidised wax or epoxidised fatty acid ester recovered from Vernonia Galamensis seeds can also be bound to bio-available molecules, such as proteins, to modify the effect of the bio-available molecules when administered to the human body.

Abstract: A thermophilic microorganism is modified to permit the increased production of ethanol, wherein a first modification is the inactivation of the lactate dehydrogenase gene and a second modification upregulates the pyruvate dehydrogenase gene.

Abstract: Modified microorganisms are prepared by inactivation of the endogenous lactate dehydrogenase gene. The microorganisms are deposited under NCIMB Accession Nos. 41277, 41278, 41279, 41280 or 41281.

Abstract: A mutated thermophilic microorganism is prepared, with a modification to inactivate the lactate dehydrogenase gene of a wild-type microorganism. The mutated microorganism is used in the production of ethanol, utilising C3, C5 or C6 sugars as the substrate.

Abstract: The present invention is a method for the production of thermophilic microorganisms suitable for the production of ethanol, comprising: (i) culturing a thermophilic microorganism under aerobic or anaerobic conditions in a suitable culture media; and (ii) incorporating amounts of ethanol into the culture media to induce ethanol tolerance.

Abstract: A printed wiring assembly comprising, a printed wiring board, a ball grid array coupled to the printed wiring board, and a high density surface mount part array disposed on the printed wiring board.

Abstract: A method of combating toxicity caused by an antifolate compound of Formula I, in an individual who has been administered the compound. The method comprises administering an enzyme that has carboxypeptidase G activity to the individual.

Abstract: Epoxidised oil, epoxidised wax or epoxidised fatty acid ester recovered from Vernonia Galamensis seeds provide topical medicament preparations which are effective in preventing and treating various different forms of skin diseases, skin lesions and wounds. These epoxidised oil, epoxidised wax or epoxidised fatty acid ester recovered from Vernonia Galamensis seeds can also be bound to bio-available molecules, such as proteins, to modify the effect of the bio-available molecules when administered to the human body.

Abstract: The reduced or “leuco” forms of certain pharmaceutical compounds can be produced and/or stabilised by mixing the unreduced compounds or the reduced compounds, respectively, with acid and a sulphydryl compound, especially a sulphur-containing amino acid, or peptide or derivative of such an amino acid.

Abstract: Disclosed is a method of detecting the presence in a sample of a polypeptide exogenously administered to a mammalian subject from whom the sample is obtained, and distinguishing between such an exogenously administered polypeptide and a naturally-occurring endogenous polypeptide present in the sample; the method comprising obtaining a sample from the subject; and subjecting the sample to analysis of fluorescence at a suitable wavelength; wherein the exogenously administered polypeptide is tagged with a greater or lesser amount of fluorescence activity, relative to the untagged endogenous polypeptide, at the wavelength(s) analyzed.

Abstract: The reduced (or ‘leuco’) forms of certain pharmaceutically active compounds can be used for the treatment or pro-phylaxis methaemoglobinaemia or of a disease or disorder associated with or resulting from oxidative stress, such as Alzheimer's disease, motor neurone disease, Lewy Body disease, Pick's disease, Progressive Supranuclear Palsy, ischaemia, myocardial infarction, acute lung injury, stroke, Parkinson's disease or haemolysis and anaemia in acute falciparum malaria.

Abstract: A method for preventing the formation of platelet-rich clots or thrombus, and for deaggregating platelet-rich clots or thrombus, using hementin, a polypeptide derived from leech salivary glands. Hementin may be administered for this purpose in a pharmaceutically acceptable carrier or excipient, with or without additional anticoagulants such as hirudin, hirudin analogues, or an inhibitor of factor Xa.

Abstract: A pharmaceutical composition for use in the prophylaxis or treatment of pathological conditions resulting from the presence of superoxide radicals, comprising a manganese-superoxide dismutase (MnSOD) enzyme and a pharmaceutically acceptable excipient. The MnSOD enzyme is in native form and has substantially the amino acid sequence of SEQ ID NO: 17 or SEQ ID NO: 29 and is free of pyrogens consisting of macromolecular substances native to Bacillus Stearothermophilus (BS) or Bacillus Caldotenax (BC). Processes for producing the novel pharmaceutical composition and a method for the prophylaxis or treatment of pathological conditions resulting from the presence of superoxide radicals utilizing the novel composition are also disclosed.

Abstract: A polypeptide derived from leeches of the species Hirudinaria manillensis has the following amino acid sequence: ##STR1## wherein Xaa indicates any amino acid residue; D indicates Cys or Pro; E indicates Glu, Asp or His; F indicates Asp, Lys or Trp; or a pharmaceutically acceptable salt, derivative or bioprecursor thereof. The polypeptide, and fragments thereof, is a specific anti-thrombin useful as a medicament.

Abstract: A method for the estimation of a salicylate in a sample is characterized by enzymatically converting the salicylate to a catechol by the action of a salicylate mono-oxygenase enzyme on the salicylate in the presence of a reduced pyridine nucleotide, reacting the catechol with a compound selected from compounds of formula I or amine or phenolic compounds of formulae II, III or IV ##STR1##