Patents by Inventor Anthony Avella

Anthony Avella has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stabilized hemoglobin solutions
    Patent number: 7435795
    Abstract: A hemoglobin solution packaged in a flexible oxygen-impermeable container system. The container system includes a multi-layer film having at least a product contact layer, an oxygen and moisture barrier layer and an exterior layer. The flexible container system further includes an interface port for filling the flexible container with the hemoglobin solution and delivering the hemoglobin solution. The hemoglobin solution comprises a substantially stroma and tetramer free, cross linked, pyridoxylated hemoglobin solution including preservatives such as ascorbic acid, glycine and dextrose.
    Type: Grant
    Filed: February 23, 2007
    Date of Patent: October 14, 2008
    Assignee: Northfield Laboratories, Inc.
    Inventors: Robert McGinnis, Gabriel Chavez, Marc Doubleday, Richard DeWoskin, Anthony Avella
  • Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing
    Patent number: 7411044
    Abstract: A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer to tetramer and removing tetramer from the hemoglobin solution.
    Type: Grant
    Filed: August 24, 2006
    Date of Patent: August 12, 2008
    Assignee: Northfield Laboratories, Inc.
    Inventors: Anthony Avella, Richard DeWoskin, Marc Doubleday
  • Stabilized hemoglobin solutions
    Publication number: 20070173435
    Abstract: A hemoglobin solution packaged in a flexible oxygen-impermeable container system. The container system includes a multi-layer film having at least a product contact layer, an oxygen and moisture barrier layer and an exterior layer. The flexible container system further includes an interface port for filling the flexible container with the hemoglobin solution and delivering the hemoglobin solution. The hemoglobin solution comprises a substantially stroma and tetramer free, cross linked, pyridoxylated hemoglobin solution including preservatives such as ascorbic acid, glycine and dextrose.
    Type: Application
    Filed: February 23, 2007
    Publication date: July 26, 2007
    Applicant: Northfield Laboratories, Inc.
    Inventors: Robert McGinnis, Gabriel Chavez, Marc Doubleday, Richard DeWoskin, Anthony Avella
  • Stabilized hemoglobin solutions
    Patent number: 7202341
    Abstract: A hemoglobin solution packaged in a flexible oxygen-impermeable container system. The container system includes a multi-layer film having at least a product contact layer, an oxygen and moisture barrier layer and an exterior layer. The flexible container system further includes an interface port for filling the flexible container with the hemoglobin solution and delivering the hemoglobin solution. The hemoglobin solution comprises a substantially stroma and tetramer free, cross linked, pyridoxylated hemoglobin solution including preservatives such as ascorbic acid, glycine and dextrose.
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: April 10, 2007
    Assignee: Northfield Laboratories, Inc.
    Inventors: Robert McGinnis, Gabriel Chavez, Marc Doubleday, Richard DeWoskin, Anthony Avella
  • Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing
    Publication number: 20060287222
    Abstract: A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer to tetramer and removing tetramer from the hemoglobin solution.
    Type: Application
    Filed: August 24, 2006
    Publication date: December 21, 2006
    Applicant: Northfield Laboratories, Inc.
    Inventors: Anthony Avella, Richard DeWoskin, Marc Doubleday
  • Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing
    Patent number: 7135553
    Abstract: A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer to tetramer and removing tetramer from the hemoglobin solution.
    Type: Grant
    Filed: January 29, 2004
    Date of Patent: November 14, 2006
    Assignee: Northfield Laboratories, Inc.
    Inventors: Anthony Avella, Richard DeWoskin, Marc Doubleday
  • Stabilized hemoglobin solutions
    Publication number: 20060014671
    Abstract: A hemoglobin solution packaged in a flexible oxygen-impermeable container system. The container system includes a multi-layer film having at least a product contact layer, an oxygen and moisture barrier layer and an exterior layer. The flexible container system further includes an interface port for filling the flexible container with the hemoglobin solution and delivering the hemoglobin solution. The hemoglobin solution comprises a substantially stroma and tetramer free, cross linked, pyridoxylated hemoglobin solution including preservatives such as ascorbic acid, glycine and dextrose.
    Type: Application
    Filed: September 21, 2005
    Publication date: January 19, 2006
    Applicant: Northfield Laboratories, Inc.
    Inventors: Robert McGinnis, Gabriel Chavez, Marc Doubleday, Richard DeWoskin, Anthony Avella
  • Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing
    Publication number: 20040186047
    Abstract: A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer to tetramer and removing tetramer from the hemoglobin solution.
    Type: Application
    Filed: January 29, 2004
    Publication date: September 23, 2004
    Applicant: Northfield Laboratories
    Inventors: Anthony Avella, Richard DeWoskin, Marc Doubleday
  • Stabilized hemoglobin solutions
    Publication number: 20030065149
    Abstract: A hemoglobin solution packaged in a flexible oxygen-impermeable container system. The container system includes a multi-layer film having at least a product contact layer, an oxygen and moisture barrier layer and an exterior layer. The flexible container system further includes an interface port for filling the flexible container with the hemoglobin solution and delivering the hemoglobin solution. The hemoglobin solution comprises a substantially stroma and tetramer free, cross linked, pyridoxylated hemoglobin solution including preservatives such as ascorbic acid, glycine and dextrose.
    Type: Application
    Filed: April 18, 2002
    Publication date: April 3, 2003
    Applicant: Northfield Laboratories
    Inventors: Robert McGinnis, Gabriel Chavez, Marc Doubleday, Richard DeWoskin, Anthony Avella