Abstract: A computer-implemented method, when executed by data processing hardware of a robot having an articulated arm and a base, causes data processing hardware to perform operations. The operations include determining a first location of a workspace of the articulated arm associated with a current base configuration of the base of the robot. The operations also include receiving a task request defining a task for the robot to perform outside of the workspace of the articulated arm at the first location. The operations also include generating base parameters associated with the task request. The operations further include instructing, using the generated base parameters, the base of the robot to move from the current base configuration to an anticipatory base configuration.

Abstract: A system for monitoring tissue lesion development during a medical ablation process applied to a patient, the system comprising a catheter ablation device having at least one catheter electrode, the device connectable via an electrical feedline to a source of electrical energy and configured to apply ablation energy to ablate tissue in a target region, a plurality of external electrodes for application to the body of the patient, measurement circuitry for determining an electrical characteristic of a current path between the at least one catheter electrode and the external electrodes in the absence of said application of ablation energy, and an electrical controller.

Abstract: The invention relates to a catheter ablation device for delivery of energy to a selected region of tissue, the device having an antenna portion including a radiating antenna electrically connectable via an electrical feedline to a source of energy, the antenna configured to generate an electromagnetic field able to ablate tissue in said selected region of tissue, the device including a thermocouple having a hot junction formed by electrical connection between a thermocouple conductor and a conducting part of the electrical feedline. This avoids the need for a dedicated thermocouple conductor pair, as the second conductor of the thermocouple is provided by the feedline used to supply the ablation energy to the device antenna.

Abstract: The invention relates to a catheter ablation device for delivery of energy (such as microwave energy) via a radiating antenna to a selected region of tissue, the device having an elongated catheter with an outer sheath, configured to allow flow of fluid along the catheter to exit through one or more orifices adjacent to the antenna. The device includes an impedance monitoring system having two electrodes arranged respectively inside and outside said catheter sheath, the impedance monitoring system including an electric circuit incorporating an ionic conductivity path through said fluid. The device is introduced into a blood vessel and the invention allows monitoring of changes in the size of the blood vessel during an ablation procedure, as it can be used to measure the impedance of an electrical circuit including a blood path in the blood vessel in the region of the ablation, the measured impedance providing a measure of vascular calibre.

Abstract: The invention relates to an ablation device for delivery of microwave energy to a selected region of tissue, in particular for producing deep endocardial or epicardial ventricular lesions, such as for the treatment or prevention of arrhythmias.

Abstract: A microwave ablation device (10) comprises a feed line (22), a microwave radiator and a device outer sheath (46) in which at least part of the feed line (22) is contained. The sheath (46) in use, allows an irrigation liquid to flow therethrough, wherein the feed line has a junction (38) with the radiator (22) has an outer conducting shield (28) terminating and insulated at the junction (38). The feed line (22) has a conductive core (32) that extends to the radiator (24). The conductive core forms a radiating element (34) electrically insulated from its surrounding environment. The radiator (24) is unbalanced.

Abstract: A hemostatic device comprising a biomaterial matrix and a polymeric material prepared by combining the polymeric material with a solvent, applying the combination to the biomaterial, removing the solvent, and retaining an effective layer of the polymeric material to the biomaterial to enhance the performance of the hemostatic device in the treatment of wounds.

Abstract: The invention concerns a method for intra-operative monitoring of the effectiveness of transcatheter renal denervation in a patient, to assist in guiding the procedure and in particular for identifying a physiological procedural endpoint. Through aorticorenal ganglia pace-capture, renal sympathetic nerve function can be assessed. In accordance with the invention, sustained reduction or abolition of renal vasoconstriction induced by the pacing is used as an indicator of successful renal denervation.

Abstract: A method, apparatus, and User Interface, and product for assisting users learning to play the Chords of any selected Song quickly and easily and provide a Means to quickly and easily generate the individual Note sounds for the Chords of the selected Song employing a broad range of Virtual and Physical Instrument.

Abstract: The disclosure provides a multilayered hemostatic device including a first layer including carboxymethyl cellulose, a second layer including a powdered hemostatic agent provided on the first layer, and a third layer including at least one of gauze, oxidized cellulose, or collagen provided on the second layer, wherein the first layer and the third layer encapsulate the second layer and the hemostatic agent comprises one of fibrinogen, thrombin, fibrin monomers, or the combination of thrombin and gelatin.

Abstract: A method, apparatus, and User Interface, and product for assisting users learning to play the Chords of any selected Song quickly and easily and provide a Means to quickly and easily generate the individual Note sounds for the Chords of the selected Song employing a broad range of Virtual and Physical Instrument.

Abstract: A microwave ablation device (10) comprises a feed line (22), a microwave radiator and a device outer sheath (46) in which at least part of the feed line (22) is contained. The sheath (46) in use, allows an irrigation liquid to flow therethrough, wherein the feed line has a junction (38) with the radiator (22) has an outer conducting shield (28) terminating and insulated at the junction (38). The feed line (22) has a conductive core (32) that extends to the radiator (24). The conductive core forms a radiating element (34) electrically insulated from its surrounding environment. The radiator (24) is unbalanced.

Abstract: The present disclosure relates, in general, to hemostatic compositions comprising polysaccharide based polymers, such as amylopectins, amylose, dextrins, maltodextrins and icodextrin and modified forms thereof, cross-linked with a cross-linking agent that are useful as a hemostatic composition. Also provided are methods of treating injury and slowing or stopping bleeding using a hemostatic composition disclosed herein.

Abstract: An exercise device is suitable for progressively strengthening the intrinsic muscle groups of a limb extremity and the associated limbs of a user. The device has a base unit and a gripping surface. The gripping surface can be gripped by at least one of the digits of the limb extremity of the user. The exercise device further includes a system for applying resistance. The gripping surface is configured to adapt to fit the shape of the digits of the limb extremity of the user.

Abstract: An interactive multimedia apparatus (1) usable in combination with a software suite of authoring programs (2) installed in a computing means of a mobile data processing apparatus (3) of the type having a display means (4) and one or more input means (4) is disclosed. The interactive multimedia apparatus (1) provides a bundle of tools which together enable a multimedia composition to be generated in real time on the mobile data processing apparatus (3). The present invention utilizes individual channels (11, 40) to ensure users can interact directly with individual files (10) and set various composition authoring parameters (14) both before and during a mixing cycle to dynamically create a multimedia composition.

Abstract: This invention relates to an exercise device suitable for progressively strengthening the intrinsic muscle groups of a limb extremity and the associated limbs of a user, said device comprising a base unit; a gripping surface configured to be gripped by at least one of the digits of said limb extremity of said user; and a resistance means. This invention more specifically relates to such an exercise device wherein the gripping surface is configured to adapt to fit the shape of said at least one of the digits of said limb extremity of said user.

Abstract: A biomedical return electrode for electrosurgery or radiofrequency (RF), a biomedical electrode pad (100), a system (300), and a method of treating tissue using a biomedical return electrode are disclosed. The biomedical return electrode comprises an electrode conductor (114) for receiving electrical energy from tissue via a return path, and a thermochromic liquid crystal (TLC) layer (116) coupled to the conductor (114). The TLC layer (116) changes color at one or more sites dependent upon the conductor temperature at each site. The TLC layer (116) changes color in a predetermined range of temperatures from about 40° C. to about 50° C. to alert an operator about the risk of a burn occurring. The biomedical electrode pad (100) comprises at least one such biomedical return electrode and a conductive body (112) to form a contact with tissue. The system (300) comprises an apparatus for delivering electrical energy to tissue and such a biomedical electrode pad (100).

Abstract: The present invention provides compositions of Ig fusion proteins, especially compositions including an Ig fusion protein, a bulking agent, a disaccharide, a surfactant, and a buffer. In one aspect, these compositions are stable under long-term storage or at least one freeze/thaw cycle. The invention also provides methods of preparation of the Ig fusion protein compositions. In one aspect, compositions of the invention are lyophilized. In a further aspect, the compositions are lyophilized by a process that includes an annealing step.

Abstract: The present invention provides methods for assessing and optimizing lyophilization cycle robustness. In particular, the present invention provides rapid assessment of cycle robustness with respect to a variety of lyophilization process deviations by varying a relatively small number of parameters.

Abstract: An interactive multimedia apparatus (1) usable in combination with a software suite of authoring programs (2) installed in a computing means of a mobile data processing apparatus (3) of the type having a display means (4) and one or more input means (4) is disclosed. The interactive multimedia apparatus (1) provides a bundle of tools which together enable a multimedia composition to be generated in real time on the mobile data processing apparatus (3). The present invention utilizes individual channels (11, 40) to ensure users can interact directly with individual files (10) and set various composition authoring parameters (14) both before and during a mixing cycle to dynamically create a multimedia composition.