Patents by Inventor Anthony Beauglehole

Anthony Beauglehole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-ALKYL 2-(DISUBSTITUTED)ALKYNYLADENOSINE-5-URONAMIDES AS A2A AGONISTS
    Publication number: 20190077824
    Abstract: The present invention provides N-alkyl 2-(disubstituted)alkynyladenosine-5?-uronamides and derivatives thereof and pharmaceutical compositions containing the same that are selective agonists of A2A adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
    Type: Application
    Filed: November 20, 2017
    Publication date: March 14, 2019
    Inventors: Robert D. Thompson, Anthony Beauglehole, Guoquan Wang
  • N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A agonists
    Patent number: 9822141
    Abstract: The present invention provides N-alkyl 2-(disubstituted)alkynyladenosine-5?-uronamides and derivatives thereof and pharmaceutical compositions containing the same that are selective agonists of A2A adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
    Type: Grant
    Filed: June 27, 2015
    Date of Patent: November 21, 2017
    Assignee: Lewis and Clark Pharmaceuticals, Inc.
    Inventors: Robert D Thompson, Anthony Beauglehole, Guoquan Wang
  • N-ALKYL 2-(DISUBSTITUTED)ALKYNYLADENOSINE-5-URONAMIDES AS A2A AGONISTS
    Publication number: 20170283452
    Abstract: The present invention provides N-alkyl 2-(disubstituted)alkynyladenosine-5?-uronamides and derivatives thereof and pharmaceutical compositions containing the same that are selective agonists of A2A adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
    Type: Application
    Filed: June 27, 2015
    Publication date: October 5, 2017
    Inventors: Robert D. Thompson, Anthony Beauglehole, Guoquan Wang
  • Xanthine-substituted alkynyl carbamates/reverse carbamates as AB antagonists
    Patent number: 9593118
    Abstract: The present invention provides xanthine-substituted alkynyl carbamates/reverse carbamates and derivatives thereof and pharmaceutical compositions containing the same that are selective antagonists of A2B adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: March 14, 2017
    Assignee: Lewis and Clark Pharmaceuticals, Inc.
    Inventors: Robert D. Thompson, Anthony Beauglehole, Guoquan Wang
  • N-ALKYL 2-(DISUBSTITUTED)ALKYNYLADENOSINE-5-URONAMIDES AS A2A AGONISTS
    Publication number: 20160376302
    Abstract: The present invention provides N-alkyl 2-(disubstituted)alkynyladenosine-5?-uronamides and derivatives thereof and pharmaceutical compositions containing the same that are selective agonists of A2A adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
    Type: Application
    Filed: June 27, 2015
    Publication date: December 29, 2016
    Inventors: Robert D. Thompson, Anthony Beauglehole, Guoquan Wang
  • N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as AA agonists
    Patent number: 9067963
    Abstract: The present invention provides N-alkyl 2-(disubstituted)alkynyladenosine-5?-uronamides and derivatives thereof and pharmaceutical compositions containing the same that are selective agonists of A2A adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: June 30, 2015
    Assignee: Lewis and Clark Pharmaceuticals, LLC
    Inventors: Robert D Thompson, Anthony Beauglehole, Guoquan Wang
  • N-ALKYL 2-(DISUBSTITUTED)ALKYNYLADENOSINE-5-URONAMIDES AS A2A AGONISTS
    Publication number: 20140037538
    Abstract: The present invention provides N-alkyl 2-(disubstituted)alkynyladenosine-5?-uronamides and derivatives thereof and pharmaceutical compositions containing the same that are selective agonists of A2A adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
    Type: Application
    Filed: July 31, 2013
    Publication date: February 6, 2014
    Inventors: Robert D. Thompson, Anthony Beauglehole, Guoquan Wang
  • Substituted 4-{3-[6-amino-9-(3, 4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as AR agonists
    Patent number: 8293720
    Abstract: The present invention provides substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters and pharmaceutical compositions containing the same that are selective agonists of A2A adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: October 23, 2012
    Assignee: Dogwood Pharmaceuticals, Inc.
    Inventors: Robert D Thompson, Anthony Beauglehole, Frank Schmidtmann, Jayson M. Rieger
  • Substituted 4-{3-[6-amino-9-(3, 4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as AR agonists
    Patent number: 8252767
    Abstract: The present invention provides substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters and pharmaceutical compositions containing the same that are selective agonists of A2A adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
    Type: Grant
    Filed: December 20, 2008
    Date of Patent: August 28, 2012
    Assignee: Dogwood Pharmaceuticals, Inc.
    Inventors: Robert Thompson, Anthony Beauglehole, Frank Schmidtmann, Jayson Rieger
  • Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as AR agonists
    Patent number: 8058259
    Abstract: The present invention provides substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters and pharmaceutical compositions containing the same that are selective agonists of A2A adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: November 15, 2011
    Assignee: University of Virginia Patent Foundation
    Inventors: Robert Douglas Thompson, Anthony Beauglehole, Frank W. Schmidtmann, Jayson M. Rieger
  • Selective antagonists of Aadenosine receptors
    Patent number: 7985754
    Abstract: The present invention provides compounds of formulae Ia and Ib: wherein R1-5, Q, X, Y, Z, p, q, and r are as defined herein. The compounds are potent and selective antagonists of A2A adenosine receptors (ARs). The invention further includes pharmaceutical compositions containing these compounds and methods of using the same.
    Type: Grant
    Filed: July 16, 2007
    Date of Patent: July 26, 2011
    Assignee: Trovis Pharmaceuticals, LLC
    Inventors: Anthony Beauglehole, Jayson M. Rieger, Robert D. Thompson
  • Substituted 8-[6-amino-3pyridyl]xanthines
    Patent number: 7875608
    Abstract: The present invention provides substituted 8-[6-amino-3-pyridyl]xanthines like the compound shown in the following formula: and pharmaceutical compositions that are selective antagonists of A2B adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: January 25, 2011
    Inventors: Robert D. Thompson, Guoquan Wang, Anthony Beauglehole, Frank Schmidtmann
  • SUBSTITUTED 4--PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS
    Publication number: 20110003765
    Abstract: The present invention provides substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters and pharmaceutical compositions containing the same that are selective agonists of A2A adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
    Type: Application
    Filed: December 20, 2008
    Publication date: January 6, 2011
    Inventors: Robert Thompson, Anthony Beauglehole, Frank Schmidtmann, Jayson Rieger
  • INTRATHECAL TREATMENT OF NEUROPATHIC PAIN WITH A2AR AGONISTS
    Publication number: 20090181920
    Abstract: The present invention relates to a method of treating neuropathic pain via intrathecal administration of agonists of A2A adenosine receptors (ARs).
    Type: Application
    Filed: January 9, 2009
    Publication date: July 16, 2009
    Applicant: PGXHEALTH, LLC
    Inventors: Linda Watkins, Lisa C. Loram, Mark Hutchinson, Robert D. Thompson, Anthony Beauglehole, Frank W. Schmidtmann, Jayson M. Rieger
  • SUBSTITUTED 4--PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS
    Publication number: 20090162292
    Abstract: The present invention provides substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters and pharmaceutical compositions containing the same that are selective agonists of A2A adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
    Type: Application
    Filed: December 18, 2008
    Publication date: June 25, 2009
    Applicant: PGXHEALTH, LLC
    Inventors: Robert D. Thompson, Anthony Beauglehole, Frank Schmidtmann, Jayson M. Rieger
  • SUBSTITUTED 4--PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS
    Publication number: 20090162282
    Abstract: The present invention provides substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters and pharmaceutical compositions containing the same that are selective agonists of A2A adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
    Type: Application
    Filed: December 18, 2008
    Publication date: June 25, 2009
    Inventors: Robert Douglas Thompson, Anthony Beauglehole, Frank W. Schmidtmann, Jayson M. Rieger
  • SUBSTITUTED 8-[6-AMINO-3PYRIDYL]XANTHINES
    Publication number: 20090163491
    Abstract: The present invention provides substituted 8-[6-amino-3-pyridyl]xanthines and pharmaceutical compositions that are selective antagonists of A2B adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
    Type: Application
    Filed: December 17, 2008
    Publication date: June 25, 2009
    Inventors: Robert D. Thompson, Guoquan Wang, Anthony Beauglehole, Frank Schmidtmann
  • Selective antagonists of A2A adenosine receptors
    Publication number: 20090118309
    Abstract: The present invention provides compounds of formulae Ia and Ib: wherein R1-5, Q, X, Y, Z, p, q, and r are as defined herein. The compounds are potent and selective antagonists of A2A adenosine receptors (ARs). The invention further includes pharmaceutical compositions containing these compounds and methods of using the same.
    Type: Application
    Filed: July 16, 2007
    Publication date: May 7, 2009
    Inventors: Anthony Beauglehole, Jayson M. Rieger, Robert D. Thompson
  • SELECTIVE ANTAGONISTS OF A2A ADENOSINE RECEPTORS
    Publication number: 20080176858
    Abstract: Selective antagonists of A2A adenosine receptors like those of formula I are provided, wherein Y forms a ring. The novel A2A Blockers are useful for the treatment of Parkinson's disease and other diseases.
    Type: Application
    Filed: March 17, 2008
    Publication date: July 24, 2008
    Applicant: Adenosine Therapeutics, LLC
    Inventors: Anthony Beauglehole, Jayson M. Riegar, Robert D. Thompson
  • Selective antagonists of A2A adenosine receptors
    Publication number: 20070244134
    Abstract: Selective antagonists of A2A adenosine receptors like those of formula I are provided, wherein Y forms a ring. The novel A2A Blockers are useful for the treatment of Parkinson's disease and other diseases.
    Type: Application
    Filed: May 14, 2007
    Publication date: October 18, 2007
    Inventors: Anthony Beauglehole, Jayson Rieger, Robert Thompson