Abstract: Methods disclosed herein relate to receptor-mediated uptake of circulating tumor DNA (ctDNA) and derivatives thereof, including synthetic delivery systems. Provided are methods of identifying a receptor that mediates or is associated with uptake of ctDNA, methods of reducing ctDNA uptake by target cells, methods of determining an expression level of a receptor associated with uptake of ctDNA, and methods of treatment that can be based on an expression level of the receptor.

Abstract: An inflatable lift system for a vehicle includes N bladders arranged vertically in a stack, where N is an integer greater than two. N pressure sensors are configured to sense pressure in the N bladders, respectively. A compressor is configured to supply pressurized gas. N valves are configured to selectively connect and disconnect the N bladders to the compressor. A controller is configured to control the N valves to inflate the N bladders sequentially in a first predetermined order and to deflate the N bladders sequentially in reverse.

Abstract: A tension-loaded drive mechanism (“mechanism”) is provided for a cargo unloader. The drive mechanism includes a compressor for increasing the pressure of a fluid. The drive mechanism further includes multiple bladders fluidly connected to the compressor to receive the fluid from the compressor and expand in a rearward direction along a longitudinal axis of a cargo bed. The mechanism further includes a strap system having multiple straps attached to each bladder. The strap system further includes multiple spools configured to apply a compression counter force via the straps to the associated bladders, such that the compression counter force increases the pressure of the fluid in the associated bladders to a predetermined drive pressure threshold. The spools are further configured to dispense an associated one of the straps at a predetermined stepped payout rate such that the associated bladders apply a drive force associated with the predetermined drive pressure threshold.

Abstract: A cargo bed divider system for a pickup truck includes a first guide rail connectable to a first lateral side of a cargo bed, a second guide rail connectable to a second lateral side of the cargo bed, a cargo bed divider supported between the first guide rail and the second guide rail, and an adjustment mechanism connectable to a forward end of the cargo bed and the cargo bed divider. The adjustment mechanism selectively moves the cargo bed divider between a first position adjacent the forward end of the cargo bed and a second position adjacent to a rear end of the cargo bed.

Abstract: A vehicle includes a chassis, a passenger compartment supported by the chassis, and a box supported by the chassis spaced from the passenger compartment. The box including a lower bed fixedly mounted to the chassis, an upper bed, and a tail gate pivotally connected to the upper bed. Each of the upper bed, and the tail gate is shiftable relative to the lower bed.

Abstract: A cargo bed divider system for a pickup truck includes a first guide rail connectable to a first lateral side of a cargo bed, a second guide rail connectable to a second lateral side of the cargo bed, a cargo bed divider supported between the first guide rail and the second guide rail, and an adjustment mechanism connectable to a forward end of the cargo bed and the cargo bed divider. The adjustment mechanism selectively moves the cargo bed divider between a first position adjacent the forward end of the cargo bed and a second position adjacent to a rear end of the cargo bed.

Abstract: A roof and rack assembly for a vehicle includes a roof assembly including a roof panel extending laterally from a first side panel to a second side panel of the vehicle, defining a recess between the each of the first side panel and second side panel, and the roof panel. One or more pedestal brackets are secured to the roof assembly at the recess. A rack assembly includes a pedestal located at each recess and secured to the pedestal bracket, and a crossbar extending between the pedestals and secured thereto.

Abstract: A vehicle includes a chassis, a passenger compartment supported by the chassis, and a box supported by the chassis spaced from the passenger compartment. The box including a lower bed fixedly mounted to the chassis, an upper bed, and a tail gate pivotally connected to the upper bed. Each of the upper bed, and the tail gate is shiftable relative to the lower bed.

Abstract: A golfer training aid for use in teaching a golfer how to square up the face of the golf club at impact resulting in golf shots having substantial accuracy. The device is a one-piece or multi-piece flat-face practice golf ball. The one-piece or multi-piece practice golf ball is shaped with a flat face 2 on one side. (FIG. 1B). The flat face has a 90-degree or right angle cut 4 to the radial portion or circular embodiment 3 of the semi-sphere 1. The importance of this unique feature is that it enables the golfer to position the flat side of the club face with the flat face of the practice golf ball and contact the ball flush and correctly. The flat face practice golf ball helps teach the golfer to hit a variety of controlled fades and a variety of controlled draws, a straight shot, as well as a backspin or descending blow, or a flop shot.

Abstract: A golfer training aid for use in teaching a golfer how to square up the face of the golf club at impact resulting in golf shots having substantial accuracy. The device is a one-piece or multi-piece flat-face practice golf ball. The one-piece or multi-piece practice golf ball is shaped with a flat face 2 on one side. (FIG. 1B). The flat face has a 90-degree or right angle cut 4 to the radial portion or circular embodiment 3 of the semi-sphere 1. The importance of this unique feature is that it enables the golfer to position the flat side of the club face with the flat face of the practice golf ball and contact the ball flush and correctly. The flat face practice golf ball helps teach the golfer to hit a variety of controlled fades and a variety of controlled draws, a straight shot, as well as a backspin or descending blow, or a flop shot.

Abstract: An article locating system comprises a first unit having a housing and a circuit for generating a coded search signal that is unique to the first unit. The first unit operatively communicates with a second unit attached to the article to be located. The second unit includes a housing and a circuit for receiving the search signal and for generating a found signal. The second unit transmits the found signal to the first unit which then responds by selectively activating an indicator connected to the circuit of the first unit. The indicator preferably includes an array of indicator lights that are programmed to illuminate in a sequence to indicate the proximate position of the second unit relative to the first unit for locating the article. In an alternative embodiment, the second unit includes a record/playback device for recording and playing an audible communication in response to receiving the first signal from the first unit.

Abstract: Under the present invention, user interface pages are served to a user so that the user can access “information” files in real-time using a web browser or the like. In a typical embodiment, the user will input login data, which will be used to access his/her access control permissions. Based on the access control permissions, the files the user is authorized to access will be displayed in a list along with a list of links to other computer systems in the network the user can access. When the user selects a desired file, that file will be retrieved in real-time and the information therein will be communicated to the user for viewing in the interface pages.