Abstract: A process for preparing a tetra-substituted aminobiphenol macrocyclic ligand having the structure (I), including the step of treating a precursor compound having the structure (II) with a compound having the structure R6-L where L is a leaving group (hereafter compound (III)) in the presence of a base.

Abstract: Disclosed are polymorphs of the isethionate salt of 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, which is a selective cyclin-dependent kinase 4 (CDK4) inhibitor useful for treating inflammation and cell proliferative diseases such as cancer and restenosis.

Abstract: An 8 Stroke and 4 Stroke cycle change engine where alternate ‘air only’ inductions are used under half load provided by alternate opening inlet valves operated by Electro-Magnetic, Electro-Hydraulic or other electrically controlled means and where the electronic control of the inlet valves can also open all inlet valves on all induction strokes to deliver more power in 4 stroke mode. The electronic control also allows for different inlet valve timings for each adjacent fuel/air 4 Stroke cycle and the next ‘air only’ 4 Stroke cycle. Electronic control of the inlet valve timing also allows an ‘air only’ inlet valve to open and admit air during an induction stroke when a fuel/air inlet valve also opens thus admitting a larger volume of air to give increased power in the fuel efficient alternate ‘air only’ 8 Stroke mode.

Abstract: An 8 stroke and 4 stroke piston engine with at least one inlet valve where there is a small volume, namely less than 10% of the swept cylinder volume, of inlet air between the seat of the throttle and the seat of the inlet valve at idling speed. The throttle can be disc or cone shaped or shaped to generally fill the volume between the closed throttle and the inlet valve seat. For higher power the throttle moves away from the inlet valve to open the inlet port. Fuel is injected into the small volume between the throttle and the inlet valve where engine heat helps vaporise the fuel without heating a large mass of the inlet air.

Abstract: Disclosed are polymorphs of the isethionate salt of 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, which is a selective cyclin-dependent kinase 4 (CDK4) inhibitor useful for treating inflammation and cell proliferative diseases such as cancer and restenosis.

Abstract: In a thermal-radiation imaging device a detector element comprises a semiconductor strip, e.g. of n-type cadmium mercury telluride, on which biasing-electrode means are spaced for causing a bias current predominantly of majority charge carriers to flow along each strip. The bias current supports an ambipolar drift of radiation-generated charge carriers in the opposite direction. A readout area is present in a part of the drift path between a pair of spaced electrodes. At least one space extends locally across the width of strip in-between the spaced readout electrodes from at least one side of the readout area to narrow at least locally the drift path in the readout area and to increase the electric field. A detector having increased responsivity results, particularly when at least two spaces extend from opposite sides to form a meandering drift path in the read-out area. Close spacing of the readout electrodes permits good image resolution even with a long meandering drift path.

Abstract: In a thermal-radiation imaging device a plurality of photoconductive detector elements are present on a common substrate. Each detector element comprises a semiconductor strip on which biasing-electrode means are spaced for causing a bias current predominantly of majority charge carriers to flow along each strip. The bias current supports an ambipolar drift of radiation-generated charge carriers in the opposite direction. Readout means for detecting these carriers comprises a connection protruding from one side of the strip. A recess extends across part of the width of the strip at the side opposite the readout connection. The readout connection of one strip extends into the recess of an adjacent strip so that a compact, closely-spaced and substantially aligned arrangement of the parallel detector elements can be obtained.