Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).

Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a promoter from a GmTEFs1 gene. Some embodiments relate to a promoter or a 5? UTR from a GmTEFs1 gene that functions in plants to promote transcription of operably linked nucleotide sequences. Other embodiments relate to a 3? UTR or a terminator from a GmTEFs1 gene that functions in plants to promote transcription of operably linked nucleotide sequences.

Abstract: A putting aid which includes a base plate, guide rails attached to the base plate, which are spaced apart to form a guide passage for a putting stroke, and markers which are engaged with guide rails, each marker being engageable with the ground at a defined position, wherein the base plate and the guide rails are movable leaving the markers at the defined positions.

Abstract: There is described zeolites containing releasably adsorbed nitric oxide, methods of preparing the zeolites, methods of releasing the nitric oxide into a solution or into air and uses of the zeolites in therapy.

Abstract: Improved apparatus and methods for non-invasively assessing one or more hemodynamic parameters associated with the circulatory system of a living organism. In one aspect, the invention comprises apparatus adapted to accurately place and maintain a sensor (e.g., tonometric pressure sensor) with respect to the anatomy of the subject, including an alignment apparatus which is separable from an adjustable fixture. The alignment apparatus moveably captures the sensor to, inter alia, facilitate coupling thereof to an actuator used to position the sensor during measurements. The alignment apparatus also advantageously allows the sensor position to be maintained when the fixture is removed from the subject, such as during patient transport. Methods for positioning the alignment apparatus and sensor, correcting for hydrostatic pressure effects, and providing treatment to the subject are also disclosed.

Abstract: Improved apparatus and methods for non-invasively assessing one or more hemodynamic parameters associated with the circulatory system of a living organism. In one aspect, the invention comprises apparatus adapted to accurately place and maintain a sensor (e.g., tonometric pressure sensor) with respect to the anatomy of the subject, including an alignment apparatus which is separable from an adjustable fixture. The alignment apparatus moveably captures the sensor to, inter alia, facilitate coupling thereof to an actuator used to position the sensor during measurements. The alignment apparatus also advantageously allows the sensor position to be maintained when the fixture is removed from the subject, such as during patient transport. Methods for positioning the alignment apparatus and sensor, correcting for hydrostatic pressure effects, and providing treatment to the subject are also disclosed.

Abstract: A telephone is disclosed which comprises a memory (6) for storing first information, such as ID information, and a memory module receiver (10) for removably receiving a memory module for storing second information, such as ID information. The telephone also comprises a microprocessor (4) for detecting a change in contact between the memory module and the memory module receiver (10) since the previous use of the telephone. The microprocessor (4) uses the first information when the memory module and receiving means are not in contact and the second information when memory module and receiving means are in contact whilst there is no change detected. However, when a change is detected, the information to be used by the microprocessor (4) is selected, either automatically or manually.

Abstract: A telephone is disclosed which comprises a memory (6) for storing first information, such as ID information, and a memory module receiver (10) for removably receiving a memory module for storing second information, such as ID information. The telephone also comprises a microprocessor (4) for detecting a change in contact between the memory module and the memory module receiver (10) since the previous use of the telephone. The microprocessor (4) uses the first information when the memory module and receiving means are not in contact and the second information when memory module and receiving means are in contact whilst there is no change detected. However, when a change is detected, the information to be used by the microprocessor (4) is selected, either automatically or manually.

Abstract: A turbo-machine casing comprises a part double skinned portion at a location surrounding at least one stage of rotor blades; the spaces defined between the two skins containing a heat insulating medium, and the inner of the two skins being additionally provided upon its radially innermost surface with a lining of heat insulating material, the casing being connected to a mass disposed radially outwardly of the casing whereby the rate of thermal expansion of the casing can be reduced nearly equal to the bladed rotor which it surrounds.