Abstract: Systems, apparatuses, and methods disclosed herein may be directed to clips for medical implementation, including clips for a portion of a heart. The clips may be configured to close the portion of the heart, to reduce blood flow therethrough as well as passage of clots or other undesired materials. In examples, the clips may be configured to close the left atrial appendage (LAA). The closure of the LAA may reduce the possibility of stroke or other maladies stemming from fluid flow with the LAA. In examples, the clips may be positioned exterior of the LAA, to extend over an outer surface of the LAA for closure.

Abstract: Methods and apparatuses for providing a permissions-aware search and knowledge management system that incorporates user suggested results, document verification, and intelligent user activity tracking across group hierarchies to improve the quality and relevance of search results are described. The permissions-aware search and knowledge management system may enable content stored across a variety of local and cloud-based data stores to be indexed, searched, and displayed to authorized users. The identification and ranking of relevant documents corresponding with a user's search query may take into account user suggested results from the user and others assigned to the same group as the user, whether the underlying content of a search result was verified by a content owner as being up-to-date, the amount of time that has passed since the underlying content was verified by the content owner, and the recent activity of the user and related group members.

Abstract: Methods and systems are described and claimed that employ machine learning data processing models to generate for a cancer patient being treated with a radiopharmaceutical a predicted Absorbed Dose Map (ADM), a predicted PET scan or a predicted outcome parameter for an administered dose of the radiopharmaceutical.

Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: Newly identified fungal sweet-taste modifying proteins, and the cDNA encoding said proteins are described. Specifically, Myd proteins active in sweet taste activation, and the cDNA encoding the same, are described, along with methods for isolating such cDNA and for isolating and expressing such proteins. Also disclosed is use of a sweetening composition which includes the proteins of the invention, and methods to provide improved flavor to a product for oral administration.

Abstract: A vertical door latch assembly includes a housing and a bolt movably attached to the housing having a catch portion. A drive motor is located within the housing and is configured to selectively move a lock assembly between a locked position preventing movement of the bolt and an unlocked position allowing movement of the bolt. A controller is in electrical communication with the drive motor and is configured to direct the actuator lock assembly between the locked position and the unlocked position. A force sensor is in electrical communication with the controller configured to measured when a force exceeds a predetermined threshold.

Abstract: A vertical door latch assembly includes a housing and a bolt movably attached to the housing having a catch portion. A drive motor is located within the housing and is configured to selectively move a lock assembly between a locked position preventing movement of the bolt and an unlocked position allowing movement of the bolt. A battery assembly is removable from the housing when the lock assembly is in first position and fixed to the housing when the lock assembly is in a second position. A controller is in electrical communication with the drive motor and is configured to direct the actuator lock assembly between the locked position and the unlocked position.

Abstract: A valve control device includes a housing provided with a control shaft, a motor for driving the control shaft to rotate, a control circuit board connected to the motor, and a sensor for detecting a rotational position of the control shaft. The sensor is connected to the control circuit board, which controls the motor to drive the control shaft to rotate in response to a position signal returned by the sensor. The valve control device may further include a position pointer, an indicating light, or a buzzer to facilitate observation of the opening and closing position of the valve.

Abstract: A valve control device includes a housing provided with a control shaft, a motor for driving the control shaft to rotate, a control circuit board connected to the motor, and a sensor for detecting a rotational position of the control shaft. The sensor is connected to the control circuit board, which controls the motor to drive the control shaft to rotate in response to a position signal returned by the sensor. The valve control device may further include a position pointer, an indicating light, or a buzzer to facilitate observation of the opening and closing position of the valve.