Abstract: Embodiments of the present disclosure provide antibodies binding to sialic acid binding-immunoglobulin type lectin (siglec) proteins. Also provided are methods of treating and diagnosing cancer using such antibodies.

Abstract: A firearm with a slide and a frame. The slide has a slide rail. The frame has a frame rail. The frame rail interfaces with the slide rail. The frame rail has a lubrication groove and a debris removal port. The lubrication groove extends along a surface of the frame rail that bears against the slide rail during operation of the firearm. The debris removal port has gap within the frame rail proximate to an end of the lubrication groove.

Abstract: A firearm with a slide and a frame. The slide has a slide rail. The frame has a frame rail. The frame rail interfaces with the slide rail. The frame rail has a lubrication groove and a debris removal port. The lubrication groove extends along a surface of the frame rail that bears against the slide rail during operation of the firearm. The debris removal port has gap within the frame rail proximate to an end of the lubrication groove.

Abstract: A simple two-piece easily and inexpensively manufactured cord tightening device and method thereof, the device comprising: a base, cylindrical in form with walls, an interior bottom having ridges, a hollow central column, and a protrusion in the walls with an opening, the protrusion; and a handle, fashioned in the shape of a spool, with a top flange with at least one hole therein, central cylindrical cavity, and bottom flange with ridges on the bottom. The cord tightening device wherein the central cylindrical cavity of the handle fits onto the hollow central column of the base. The cord tightening device may further comprise threading in the hollow central column of the base. The cord tightening device may further comprise a screw. The cord tightening device may further comprise a spring washer. The cord tightening device may further comprise at least two holes in the top flange of the handle.

Abstract: A simple two-piece easily and inexpensively manufactured cord tightening device and method thereof, the device comprising: a base, cylindrical in form with walls, an interior bottom having ridges, a hollow central column, and a protrusion in the walls with an opening, the protrusion; and a handle, fashioned in the shape of a spool, with a top flange with at least one hole therein, central cylindrical cavity, and bottom flange with ridges on the bottom. The cord tightening device wherein the central cylindrical cavity of the handle fits onto the hollow central column of the base. The cord tightening device may further comprise threading in the hollow central column of the base. The cord tightening device may further comprise a screw. The cord tightening device may further comprise a spring washer. The cord tightening device may further comprise at least two holes in the top flange of the handle.

Abstract: A multi-user satellite system provides communication services to external satellites. This satellite system provides in-orbit access points that can be used by the external satellites to offload data instead on relying directly on ground stations. One approach to such communication is to use a set of interface satellites (“converter satellites”) that provide a gateway between a constellation of satellites that together provide communication services to one or more ground stations, but that do not necessarily have the communication capabilities to communicate with external satellites. In this way, the interface satellites can be put in compatible orbits with external satellites and provide communication gateways that can be used to offload data from the external satellites to ground stations. As external satellites change their communication methods, the interface satellites can be reconfigured or new compatible interface satellites can be launched, without having to modify the constellation of satellites.

Abstract: An intravenous (IV) set system comprising a primary IV set having a plurality of access points facilitating access to one or more fluid pathways of the primary IV set, and an IV extension set removably coupled to the primary IV set to form an extended primary IV set, the IV extension set comprising an extension flow line defining an extension flow path, and a plurality of access ports on the extension flow line, at least two of the access ports comprising access ports located between first and second ends of the IV extension set. The IV set system further comprises a bypass manifold externally and removably coupled to the extension flow line of the IV extension set via the intermediate access ports on the extension flow line, the bypass manifold comprising a bypass flow line adjacent the extension flow line, and one or more access points that facilitate access to the bypass flow line, wherein the bypass manifold and the bypass flow line are operable to provide a bypass flow path through the IV extension so.

Abstract: In some aspects of the design, novel forms of geranylpyrophosphate:olivetolate geranyltransferase; of olivetol synthase or of geranyl pyrophosphate synthase; of geranylgeranyl pyrophosphate synthase; of olivetolic acid cyclase; and/or of olivetolic acid synthase for making large scale amounts of cannabinoids in cells, in vitro are presented.

Abstract: An intravenous (IV) set system comprising a primary IV set defining a primary flow line of the IV set system. The primary flow line can include multiple access points along its length and feeds to a merging fluid pathway proximate to the distal terminus of the primary IV set. At least one secondary IV set with corresponding flow lines can be separably joined to the primary IV set to cause the secondary flow lines to be in fluid communication with the primary flow line. At least one of the IV sets can have a unique set of uniform marking indicia to facilitate rapid identification of the IV sets from other IV sets within the IV set system. Such marked and identified primary and/or secondary IV sets can be allocated to specific medical functions and/or can be for use by specific medical personnel to thereby minimize risk of error in administration of an IV to a patient. The IV set system can further comprise a merging fluid pathway about a primary IV set.

Abstract: A method for administering successive dosages of a medical fluid from a fluid injection device to a patient via an IV set during a medical procedure comprising: obtaining an IV set having a primary flow line defining a primary fluid path, and an access point defining an access port; establishing a fluid connection with a primary fluid in a fluid source with the primary fluid path; connecting a fluid injection device (e.g., syringe) to an unidirectional access port assembly comprising an anti-backflow device; injecting a first dosage of a secondary fluid (medication) from the fluid injection device into through an anti-backflow device (e.g., one-way check valve) and into the primary fluid path; maintaining the connection of the fluid injection device to the unidirectional access port assembly; and injecting a second dosage, or n number of additional dosages, of the secondary fluid through the anti-backflow device. Associated devices and systems are disclosed.

Abstract: A method of producing a component is disclosed. The method first comprises the steps of providing a base structure having a surface, providing an exoskeleton, and positioning the exoskeleton about the surface of the base structure.

Abstract: An intravenous (IV) set system comprising a primary IV set having a plurality of access points facilitating access to one or more fluid pathways of the primary IV set, and an IV extension set removably coupled to the primary IV set to form an extended primary IV set, the IV extension set comprising an extension flow line defining an extension flow path, and a plurality of access ports on the extension flow line, at least two of the access ports comprising access ports located between first and second ends of the IV extension set. The IV set system further comprises a bypass manifold externally and removably coupled to the extension flow line of the IV extension set via the intermediate access ports on the extension flow line, the bypass manifold comprising a bypass flow line adjacent the extension flow line, and one or more access points that facilitate access to the bypass flow line, wherein the bypass manifold and the bypass flow line are operable to provide a bypass flow path through the IV extension so.

Abstract: An offshore structure includes an original structure and an extension structure. The original structure includes a main platform supported via a foundation on a seabed. The extension structure includes a platform extension positioned laterally of the main platform and a platform extension support, depending downwardly from the platform extension, into contact with the foundation, so as to support the extension structure directly on the foundation.

Abstract: An intravenous (IV) set system comprising a primary IV set defining a primary flow line of the IV set system. The primary flow line can include multiple access points along its length and feeds to a merging fluid pathway proximate to the distal terminus of the primary IV set. At least one secondary IV set with corresponding flow lines can be separably joined to the primary IV set to cause the secondary flow lines to be in fluid communication with the primary flow line. At least one of the IV sets can have a unique set of uniform marking indicia to facilitate rapid identification of the IV sets from other IV sets within the IV set system. Such marked and identified primary and/or secondary IV sets can be allocated to specific medical functions and/or can be for use by specific medical personnel to thereby minimize risk of error in administration of an IV to a patient. The IV set system can further comprise a merging fluid pathway about a primary IV set.

Abstract: A Stirling engine has a housing containing a displacer and a power piston arranged to reciprocate relatively to one another. A head is adjacent to the displacer to absorb heat, and is surrounded by a block of copper or aluminum. A substantial proportion of the block is clad with a layer of stainless steel or Inconel having a thickness of between 3 mm and 0.15 mm.

Abstract: An offshore structure comprises: an original structure comprising a main platform supported via a foundation on a seabed; and an extension structure comprising a platform extension positioned laterally of the main platform and a platform extension support, depending downwardly from the platform extension, into contact with the foundation, so as to support the extension structure directly on the foundation.

Abstract: An intravenous (IV) set system comprising a primary IV set defining a primary flow line of the IV set system. The primary flow line can include multiple access points along its length and feeds to a merging fluid pathway proximate to the distal terminus of the primary IV set. At least one secondary IV set with corresponding flow lines can be separably joined to the primary IV set to cause the secondary flow lines to be in fluid communication with the primary flow line. At least one of the IV sets can have a unique set of uniform marking indicia to facilitate rapid identification of the IV sets from other IV sets within the IV set system. Such marked and identified primary and/or secondary IV sets can be allocated to specific medical functions and/or can be for use by specific medical personnel to thereby minimize risk of error in administration of an IV to a patient. The IV set system can further comprise a merging fluid pathway about a primary IV set.

Abstract: An intravenous (IV) set system comprising a primary IV set defining a primary flow line of the IV set system. The primary flow line can include multiple access points along its length and feeds to a merging fluid pathway proximate to the distal terminus of the primary IV set. At least one secondary IV set with corresponding flow lines can be separably joined to the primary IV set to cause the secondary flow lines to be in fluid communication with the primary flow line. At least one of the IV sets can have a unique set of uniform marking indicia to facilitate rapid identification of the IV sets from other IV sets within the IV set system. Such marked and identified primary and/or secondary IV sets can be allocated to specific medical functions and/or can be for use by specific medical personnel to thereby minimize risk of error in administration of an IV to a patient. The IV set system can further comprise a merging fluid pathway about a primary IV set.

Abstract: An offshore structure includes an original structure and an extension structure. The original structure includes a main platform supported via a foundation on a seabed. The extension structure includes a platform extension positioned laterally of the main platform and a platform extension support, depending downwardly from the platform extension, into contact with the foundation, so as to support the extension structure directly on the foundation.