Patents by Inventor Anthony Convertine

Anthony Convertine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220152091
    Abstract: Methods and compositions for treating traumatic brain injury. The methods and compositions utilize a multi-functional oxygen reactive polymer (ORP) that includes repeating units that include a reactive oxygen species (ROS) scavenging group and a polyalkylene oxide group. For theranostic applications, the oxygen reactive polymer further includes a diagnostic group.
    Type: Application
    Filed: July 19, 2021
    Publication date: May 19, 2022
    Applicant: University of Washington
    Inventors: Patrick S. Stayton, Menko P. Ypma, Peter A. Chiarelli, Joshua Sang Hun Park, Richard G. Ellenbogen, Julia Mengyun Xu, Pierre D. Mourad, Donghoon Lee, Anthony Convertine, Forrest M. Kievit
  • Patent number: 11065272
    Abstract: Methods and compositions for treating traumatic brain injury. The methods and compositions utilize a multi-functional oxygen reactive polymer (ORP) that includes repeating units that include a reactive oxygen species (ROS) scavenging group and a polyalkylene oxide group. For theranostic applications, the oxygen reactive polymer further includes a diagnostic group.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: July 20, 2021
    Assignee: University of Washington
    Inventors: Patrick S. Stayton, Menko P. Ypma, Peter A. Chiarelli, Joshua Sang Hun Park, Richard G. Ellenbogen, Julia Mengyun Xu, Pierre D. Mourad, Donghoon Lee, Anthony Convertine, Forrest M. Kievit
  • Publication number: 20200405881
    Abstract: Provided herein are engineered cells and methods for engineering cells to deliver a therapeutic agent, e.g., a small molecule, peptide or other drug, to a cell or tissue to be treated.
    Type: Application
    Filed: March 6, 2018
    Publication date: December 31, 2020
    Applicants: UNIVERSITY OF WASHINGTON, SEATTLE CHILDREN'S RESEARCH INSTITUTE, COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
    Inventors: Patrick S. STAYTON, Anthony CONVERTINE, Debobrato DAS, Hye-Nam SON, Selvi SRINIVASAN, Katherine MONTGOMERY, Ian BLUMENTHAL, Courtney CRANE, Michael JENSEN, James MATTHAEI, John CHIEFARI, Maarten DANIAL, Fei HUANG, James MACDONALD, Almar POSTMA, Kathleen TURNER
  • Publication number: 20200147121
    Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.
    Type: Application
    Filed: September 23, 2019
    Publication date: May 14, 2020
    Applicants: University of Washington, GENEVANT SCIENCES GMBH
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E.E. Paschal, Charbel Diab, Priyadarsi De
  • Publication number: 20190365906
    Abstract: Provided herein are particles assemblies including a shell surrounding a core. The shell includes a particle-stabilizing random copolymer. The core includes a core random copolymer. The particle assemblies have a biomimetic design in which the polymeric components containing discrete chemical and biological functionalities are designed to spontaneously self-assemble into particles. Also provided herein are random copolymers having conjugated therapeutic agents that can be cleaved from the copolymers by an enzyme or water.
    Type: Application
    Filed: April 11, 2019
    Publication date: December 5, 2019
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Patrick S. Stayton, Anthony Convertine, Daniel M. Ratner, Selvi Srinivasan, Debobrato Das, Fang-Yi Su, Jasmin Chen, David Yee-Shawn Chiu, Daniel Douglas Lane
  • Patent number: 10420790
    Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instauces, micellic assemblies provided herein are pH sensitive particles.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: September 24, 2019
    Assignees: University of Washington, GENEVANT SCIENCES GMBH
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E. E. Paschal, Charbel Diab, Priyadarsi De
  • Publication number: 20180289736
    Abstract: Methods and compositions for treating traumatic brain injury. The methods and compositions utilize a multi-functional oxygen reactive polymer (ORP) that includes repeating units that include a reactive oxygen species (ROS) scavenging group and a polyalkylene oxide group. For theranostic applications, the oxygen reactive polymer further includes a diagnostic group.
    Type: Application
    Filed: October 6, 2016
    Publication date: October 11, 2018
    Applicant: University of Washington
    Inventors: Patrick S. Stayton, Menko R. Ypma, Peter A. Chiarelli, Joshua Sang Hun Park, Richard G. Ellenbogen, Julia Mengyun Xu, Pierre D. Mourad, Donghoon Lee, Anthony Convertine, Forrest M. Kievit
  • Publication number: 20170239360
    Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instauces, micellic assemblies provided herein are pH sensitive particles.
    Type: Application
    Filed: April 27, 2017
    Publication date: August 24, 2017
    Applicants: University of Washington, PhaseRx, Inc.
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E.E. Paschal, Charbel Diab, Priyadarsi De
  • Patent number: 9662403
    Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: May 30, 2017
    Assignees: University of Washington, PhaseRx, Inc.
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E. E. Paschal, Charbel Diab, Priyadarsi De
  • Publication number: 20160279251
    Abstract: Provided herein are particles assemblies including a shell surrounding a core. The shell includes a particle-stabilizing random copolymer. The core includes a core random copolymer. The particle assemblies have a biomimetic design in which the polymeric components containing discrete chemical and biological functionalities are designed to spontaneously self-assemble into particles. Also provided herein are random copolymers having conjugated therapeutic agents that can be cleaved from the copolymers by an enzyme or water.
    Type: Application
    Filed: November 12, 2014
    Publication date: September 29, 2016
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Patrick S. Stayton, Anthony Convertine, Daniel M. Ratner, Selvi Srinivasan, Debobrato Das, Fang-Yi Su, Jasmin Chen, David Yee-Shawn Chiu, Daniel Douglas Lane
  • Publication number: 20160250338
    Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.
    Type: Application
    Filed: March 2, 2016
    Publication date: September 1, 2016
    Applicants: University of Washington, PhaseRx, Inc.
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E.E. Paschal, Charbel Diab, Priyadarsi De
  • Publication number: 20160082121
    Abstract: A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target.
    Type: Application
    Filed: December 2, 2015
    Publication date: March 24, 2016
    Applicants: University of Washington, PhaseRx, Inc.
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Robert Overell, Paul Johnson
  • Patent number: 9220791
    Abstract: A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: December 29, 2015
    Assignees: University of Washington, PhaseRx, Inc.
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Robert Overell, Paul Johnson
  • Publication number: 20140235790
    Abstract: Provided herein are compositions and methods for intracellular delivery. The compositions are polymer compositions in which the polymer serves as a carrier for therapeutic and/or diagnostic agents. The polymer compositions are effective in targeted delivery of therapeutic and/or diagnostic agents to a cell. The polymer compositions include a targeting moiety that includes carbohydrate groups that effectively target specific cell surface receptors. The polymer compositions also include an agent binding moiety that effectively associates the therapeutic and/or diagnostic agent to be delivered to the cell.
    Type: Application
    Filed: June 11, 2012
    Publication date: August 21, 2014
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Patrick Stayton, Matthew Manganiello, Anthony Convertine, Daniel M. Ratner, Yu-Hua Chow, Eun-Ho Song, Bilal Ghosn, Lynn Schnapp, Salka Keller, Debashish Roy
  • Publication number: 20140228516
    Abstract: A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target.
    Type: Application
    Filed: February 5, 2014
    Publication date: August 14, 2014
    Applicants: PHASERX, INC., UNIVERSITY OF WASHINGTON
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Robert Overell, Paul Johnson
  • Publication number: 20140161893
    Abstract: Core-shell polymer blend particles are described. The particles include a pH-responsive polymeric shell and a pH-irresponsive polymeric core. The core can include a biodegradable hydrolysable polymer and the shell can include a pH-responsive copolymer that can include constitutional units that are cationic and/or anionic at physiological pH. The core-shell polymer blend particles can allow the controlled delivery of agents into a plurality of distinct intracellular compartments.
    Type: Application
    Filed: January 10, 2014
    Publication date: June 12, 2014
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Hong Shen, Patrick S. Stayton, Anthony Convertine, Kenny K. Tran
  • Publication number: 20110123636
    Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.
    Type: Application
    Filed: May 13, 2009
    Publication date: May 26, 2011
    Applicants: UNIVERSITY OF WASHINGTON, PHASERX, INC.
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert W. Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E.E. Paschal, Charbel Diab, Priyadarsi De