Abstract: Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGF?1 with high potency. Related compositions, methods and therapeutic use are also disclosed.

Abstract: A ground cone for providing electrical contact to an interior of a conduit is provided. The ground cone includes a cone body including one or more tabs positioned on the cone body and extending radially outward from the cone body, the one or more tabs positioned separately from one another. At least one of the one or more tabs has a helical edge, the helical edge shaped to be received in a groove of a thread. The cone body includes a cap end and a bottom end opposite the cap end. The ground cone also includes a cap extending longitudinally from the cone body at the cap end and extending toward the bottom end. The cone body and the cap define a channel sized to receive an end of a conduit therein.

Abstract: The invention provides a hybrid bag which comprises a strap, a bag body, a lid, and a bag sleeve wherein the hybrid bag has a first configuration where the bag body houses the lid and the bag sleeve and a second configuration where the lid and the bag sleeve are extended from the bag body; wherein the bag body has one or more wheels; and wherein the bag sleeve is arranged between the bag body and the lid to form a container which may be accessed through the lid.

Abstract: Systems and methods for performing a pediatric lower limb alignment assessment by: receiving a pediatric lower limb radiographic image; identifying a plurality of regions of interest in the radiographic image using a first artificial intelligence model such that each one of the plurality of regions of interest contains at least one of a plurality of anatomical features of interest; determining a plurality of landmark locations for each one of the plurality of identified regions of interest in the radiographic image using a second AI model; and calculating one or more parameter values representative of the pediatric lower limb alignment based on a geometric relationship between the plurality of landmark locations.

Abstract: Multi-cell battery management devices, systems, and methods are disclosed herein. A multi-cell battery management device comprises a battery pack including a power output terminal and a plurality of battery cells each having a positive and a negative terminal and connected in series fashion. Each of the plurality of battery cells includes: i) a cell control processor to monitor cell voltage, cell current, cell temperature, and cell fuse status; ii) a programmable shunt controlled by the cell control processor that varies the internal resistance of each of the cells; and iii) a data communications circuit connected to the cell control processor and to the positive and negative terminals of each cell, the communications circuit enabling data communication over the battery cell positive and negative output terminals, and wherein the cell control processor responds to commands received via the data communications circuit to vary the operating state of the programmable shunt.

Abstract: Systems and methods for operating an add-on battery that may be electrically coupled to a second system that includes an electrical energy storage device are presented. In one example, the systems and methods provide for extending operation of the second system via selectively powering the second system via the add-on battery in response to operating conditions of the second system.

Abstract: Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGF?1 with high potency. Related compositions, methods and therapeutic use are also disclosed.

Abstract: Battery management systems and methods for using the same to obtain battery shock and/or rollover data. An exemplary battery management system of the present disclosure comprises an accelerometer configured to obtain acceleration data, a microcontroller operably connected to the accelerometer and configured to receive the acceleration data from the accelerometer, and a data storage medium in communication with the microcontroller, the data storage medium configured to store the acceleration data therein, wherein when the battery management system is in communication with a battery, the accelerometer can obtain the acceleration data relating to the battery, and the microcontroller can operate to disconnect the battery from a load connected thereto should the acceleration data meet or exceed a threshold limit.

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

Abstract: Battery management system with integrated contactor economizer. A system for reducing power consumption included herein comprises a switching mechanism comprising a switch, and a microcontroller coupled to the switching mechanism, wherein the switching mechanism is coupled to a coupling mechanism and configured to energize the coupling mechanism, and wherein the processor is configured to provides a pulse width modulated on/off signal with duty cycle ranging between 50% to 100% and frequencies between 1 KHz to 20 KHz.

Abstract: Multi-cell battery management devices, systems, and methods are disclosed herein. A multi-cell battery management device comprises a battery pack including a power output terminal and a plurality of battery cells each having a positive and a negative terminal and connected in series fashion. Each of the plurality of battery cells includes: i) a cell control processor to monitor cell voltage, cell current, cell temperature, and cell fuse status; ii) a programmable shunt controlled by the cell control processor that varies the internal resistance of each of the cells; and iii) a data communications circuit connected to the cell control processor and to the positive and negative terminals of each cell, the communications circuit enabling data communication over the battery cell positive and negative output terminals, and wherein the cell control processor responds to commands received via the data communications circuit to vary the operating state of the programmable shunt.

Abstract: A sprung display case for dispensing products, particularly heavy products such as beverage multipacks. The case comprises a vertical chamber that is open at an upper end (and is sized and shaped such that a plurality of the products can be vertically stacked within the chamber; a horizontal platform that is mounted to be vertically slidable within the chamber, the platform having at least one air hole formed therethrough; a single resiliently compressible member mounted in the chamber between a lower side of the platform and an upper side of a base of the chamber to bias the platform towards the upper end of the chamber; and a tether fixed at a first end to the platform and at a second end to the base of the chamber to prevent the platform moving out of the upper end of the chamber.

Abstract: Battery management systems and methods for using the same to obtain battery shock and/or rollover data. An exemplary battery management system of the present disclosure comprises an accelerometer configured to obtain acceleration data, a microcontroller operably connected to the accelerometer and configured to receive the acceleration data from the accelerometer, and a data storage medium in communication with the microcontroller, the data storage medium configured to store the acceleration data therein, wherein when the battery management system is in communication with a battery, the accelerometer can obtain the acceleration data relating to the battery, and the microcontroller can operate to disconnect the battery from a load connected thereto should the acceleration data meet or exceed a threshold limit.

Abstract: Multi-cell battery management devices, systems, and methods are disclosed herein. A multi-cell battery management device comprises a battery pack including a power output terminal and a plurality of battery cells each having a positive and a negative terminal and connected in series fashion. Each of the plurality of battery cells includes: i) a cell control processor to monitor cell voltage, cell current, cell temperature, and cell fuse status; ii) a programmable shunt controlled by the cell control processor that varies the internal resistance of each of the cells; and iii) a data communications circuit connected to the cell control processor and to the positive and negative terminals of each cell, the communications circuit enabling data communication over the battery cell positive and negative output terminals, and wherein the cell control processor responds to commands received via the data communications circuit to vary the operating state of the programmable shunt.

Abstract: Power systems and methods of using the same to deliver power. A power system referenced herein can include a housing capable of attaching to a workstation, one or more cradles or mounting fixtures to receive at least one energy storage device, electronic circuitry to communicate status of the at least one energy storage device, state of charge of the at least one energy storage device, and/or overall health of the at least one energy storage device, and one or more electrical connectors to allow the at least one energy storage device to charge and/or discharge and communicate with the electronic circuitry, with said housing having an internal power supply and charge circuitry, said power supply capable of receiving input power from an external AC or DC power source; wherein the power system is configured to deliver power to the workstation.

Abstract: Anti-TIGIT antibodies and antigen binding fragments thereof that inhibit TIGIT-mediated signalling are provided, together with combinations comprising said antibodies or antigen binding fragments thereof and methods for their use.