Patents by Inventor Anthony D. Piscopio

Anthony D. Piscopio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE PREPARATION OF CYCLIC DEPSIPEPTIDES
    Publication number: 20240116989
    Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.
    Type: Application
    Filed: July 14, 2023
    Publication date: April 11, 2024
    Applicant: OnKure, Inc.
    Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
  • Process for the preparation of cyclic depsipeptides
    Patent number: 11739123
    Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.
    Type: Grant
    Filed: June 7, 2021
    Date of Patent: August 29, 2023
    Assignee: OnKure, Inc.
    Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
  • Benzimidazole compounds as HDAC6 inhibitors
    Patent number: 11339150
    Abstract: Novel compounds of Formula I are described, where the compounds are selective HDAC6 inhibitors suitable for treatment of diseases associated with HDAC6, where X, Y, Z, A1, A2, Q1 and Q2 are as described.
    Type: Grant
    Filed: December 23, 2020
    Date of Patent: May 24, 2022
    Assignee: OnKure, Inc.
    Inventors: Anthony D. Piscopio, Gan Zhang, Kevin Hunt
  • BENZIMIDAZOLE COMPOUNDS AS HDAC6 INHIBITORS
    Publication number: 20220041584
    Abstract: Novel compounds of Formula I are described, where the compounds are selective HDAC6 inhibitors suitable for treatment of diseases associated with HDAC6, where X, Y, Z, A1, A2, Q1 and Q2 are as described.
    Type: Application
    Filed: December 23, 2020
    Publication date: February 10, 2022
    Applicant: OnKure, Inc.
    Inventors: Anthony D. Piscopio, Gan Zhang, Kevin Hunt
  • THIOESTER PRODRUGS OF MACROCYCLES AS INHIBITORS OF HISTONE DEACETYLASES
    Publication number: 20220017538
    Abstract: The present invention provides a novel macrocyclic prodrug compound of general Formula (I), a pharmaceutical composition comprising a compound of Formula (I), and a method for treating diseases mediated by HDAC enzymes by administering a compound of Formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, A and Z are defined herein.
    Type: Application
    Filed: June 25, 2021
    Publication date: January 20, 2022
    Applicant: OnKure, Inc.
    Inventor: Anthony D. Piscopio
  • PROCESS FOR THE PREPARATION OF CYCLIC DEPSIPEPTIDES
    Publication number: 20220002347
    Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.
    Type: Application
    Filed: June 7, 2021
    Publication date: January 6, 2022
    Applicant: ONKURE, INC.
    Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
  • Thioester prodrugs of macrocycles as inhibitors of histone deacetylases
    Patent number: 11203602
    Abstract: The present invention provides a novel macrocyclic prodrug compound of general Formula (I), a pharmaceutical composition comprising a compound of Formula (I), and a method for treating diseases mediated by HDAC enzymes by administering a compound of Formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, A and Z are defined herein.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: December 21, 2021
    Assignee: OnKure, Inc.
    Inventor: Anthony D. Piscopio
  • Process for the preparation of cyclic depsipeptides
    Patent number: 11053284
    Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: July 6, 2021
    Assignee: ONKURE, INC.
    Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
  • Process for the Preparation of Cyclic Depsipeptides
    Publication number: 20200347097
    Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.
    Type: Application
    Filed: February 4, 2020
    Publication date: November 5, 2020
    Applicant: ONKURE, INC.
    Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
  • THIOESTER PRODRUGS OF MACROCYCLES AS INHIBITORS OF HISTONE DEACETYLASES
    Publication number: 20200317693
    Abstract: The present invention provides a novel macrocyclic prodrug compound of general Formula (I), a pharmaceutical composition comprising a compound of Formula (I), and a method for treating diseases mediated by HDAC enzymes by administering a compound of Formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, A and Z are defined herein.
    Type: Application
    Filed: May 18, 2017
    Publication date: October 8, 2020
    Applicant: OnKure, Inc.
    Inventor: Anthony D. Piscopio
  • Process for the preparation of cyclic depsipeptides
    Patent number: 10689419
    Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: June 23, 2020
    Assignee: ONKURE, INC.
    Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
  • Heterocyclic hydroxamic acids as protein deacetylase inhibitors and dual protein deacetylase-protein kinase inhibitors and methods of use thereof
    Patent number: 10508122
    Abstract: The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mps1 kinase activity, pharmaceutical compositions comprising these compounds, and processes for their preparation.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: December 17, 2019
    Assignee: The Regents of the University of Colorado, A Body Corporate
    Inventors: Xuedong Liu, Gan Zhang, Daniel Chuen-Fong Chan, Anthony D. Piscopio
  • Process for the Preparation of Cyclic Depsipeptides
    Publication number: 20190177372
    Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.
    Type: Application
    Filed: September 11, 2018
    Publication date: June 13, 2019
    Applicant: ONKURE, INC.
    Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
  • Process for the preparation of cyclic depsipeptides
    Patent number: 10100089
    Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: October 16, 2018
    Assignee: ONKURE, INC.
    Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
  • Heterocyclic Hydroxamic Acids as Protein Deacetylase Inhibitors and Dual Protein Deacetylase-Protein Kinase Inhibitors and Methods of Use Thereof
    Publication number: 20180044352
    Abstract: The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mps1 kinase activity, pharmaceutical compositions comprising these compounds, and processes for their preparation.
    Type: Application
    Filed: July 19, 2017
    Publication date: February 15, 2018
    Applicant: The Regents of the University of Colorado, A Body Corporate
    Inventors: Xuedong Liu, Gan Zhang, Daniel Chuen-Fong Chan, Anthony D. Piscopio
  • Heterocyclic hydroxamic acids as protein deacetylase inhibitors and dual protein deacetylase-protein kinase inhibitors and methods of use thereof
    Patent number: 9840520
    Abstract: The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mps1 kinase activity, pharmaceutical compositions comprising these compounds, and processes for their preparation.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: December 12, 2017
    Assignee: The Regents of the University of Colorado, A Body Corporate
    Inventors: Xuedong Liu, Gan Zhang, Daniel Chuen-Fong Chan, Anthony D. Piscopio
  • Process for the Preparation of Cyclic Depsipeptides
    Publication number: 20170183382
    Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.
    Type: Application
    Filed: May 27, 2015
    Publication date: June 29, 2017
    Applicant: ONKURE, INC.
    Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
  • Heterocyclic Hydroxamic Acids as Protein Deacetylase Inhibitors and Dual Protein Deacetylase-Protein Kinase Inhibitors and Methods of Use Thereof
    Publication number: 20170081343
    Abstract: The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mps1 kinase activity, pharmaceutical compositions comprising these compounds, and processes for their preparation.
    Type: Application
    Filed: May 14, 2015
    Publication date: March 23, 2017
    Applicant: The Regents of the University of Colorado, A Body Corporate
    Inventors: Xuedong Liu, Gan Zhang, Daniel Chuen-Fong Chan, Anthony D. Piscopio
  • Processes for preparing benzimidazole compounds
    Patent number: 9024040
    Abstract: Provided are processes for the preparation of benzimidazole structures having Formula VIIIb-1: and salts and solvates thereof, wherein Z, X5, R2b, R2c and R10 are as defined herein. Compounds of Formula VIIIb-1 are useful for the preparation of benzimidazole derivatives.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: May 5, 2015
    Assignee: Array Biopharma Inc.
    Inventors: John DeMattei, Sagar Shakya, Anthony D. Piscopio, Bruno P. Hache, Matthew Charles Evans, James Gair Ford, Simon Mark Pointon, Koen Peeters, Timothy John Lilley, John Leonard
  • Heterocyclic hydroxamic acids as protein deacetylase inhibitors and dual protein deacetylase-protein kinase inhibitors and methods of use thereof
    Patent number: RE47690
    Abstract: The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mps1 kinase activity, pharmaceutical compositions comprising these compounds, and processes for their preparation.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: November 5, 2019
    Assignee: The Regents of the University of Colorado, A Body Corporate
    Inventors: Xuedong Liu, Gan Zhang, Daniel Chuen-Fong Chan, Anthony D. Piscopio