Abstract: The present invention relates to compounds that inhibit at least one of KRas wild type, KRas G12A, KRas G12C, KRas G12D, KRas G12R, KRas G12S, KRas G12V, KRas G13D and KRas Q61H, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways comprising: a cushion member that includes a retaining structure and a seal-forming structure permanently connected to the retaining structure; a frame member attachable to the retaining structure; and a positioning and stabilising structure attachable to the frame member.

Abstract: A device is configured to index file system names and paths of a single chain of backed-up snapshots. The device is configured to obtain a first snapshot of the file system. Further, the device is configured to scan the first snapshot of the file system to obtain a first scan of the nodes and the tree structure at a first time point. The device is further configured to insert the first scan into a database. Then the device is configured to index the nodes in the database.

Abstract: A device includes: a panel and an electromagnetic actuator mechanically coupled to a rear side of the panel to form a panel audio loudspeaker, the electromagnetic actuator comprising a coil attached to the rear side of the panel and a magnet suspended with respect to the coil via one or more spring elements, the coil defining an axis, wherein during operation of the device an electric current through the coil varies a relative displacement of the magnet with respect to the coil along the axis. The device includes: a chassis supporting the panel, the chassis comprising a housing for the device, the housing comprising a rear panel on an opposite side of the device from the panel; and a grounding assembly positioned along the axis between the magnet and the rear panel of the device, wherein the grounding assembly mechanically grounds the magnet to the chassis.

Abstract: An applicator instrument for dispensing surgical fasteners includes a housing, an elongated shaft, surgical fasteners disposed in the elongated shaft, a firing system for dispensing the surgical fasteners, a firing rod disposed within the elongated shaft and movable within a first plane, and an advancer disposed within the elongated shaft and moveable within a second plane. An actuator is coupled with the advancer for moving the advancer back and forth between retracted and extended positions. A staging assembly at the distal end of the elongated shaft aligns a leading surgical fastener with the first plane. The staging assembly includes a biasing device that is configured to be deflected away from the first plane by the advancer when the advancer is in the extended position and the staging assembly is configured to spring back into alignment with the first plane when the advancer returns back to the retracted position.

Abstract: Automated cold storage unit and systems for storing, monitoring, and maintaining a supply of temperature sensitive pharmaceutical and/or other products in compliance with regulatory requirements are provided. Such units contain an array of independently addressable holding locations for containers with product in one or more controlled temperature zones fitted with temperature sensors. The units include a reader to track product information and status. Product movement within the unit is performed by a computer-controlled robot. A user interface device, preferably in communication with an application service provider to provide remotely managed inventory management and other services, provides users with secure access to the contents of the unit and associated product data and information.

Abstract: A system is configured to track and provide objective behavioral data of employees based upon an employee's engagement with communications, resources, tools, and other content distributed via an organization's information systems and software. This behavioral data may be combined into an employee profile that includes employee demographic and employment information and may be analyzed by an artificial intelligence or expert function to provide a quantitative metric that describes the likelihood that the employee will depart an organization during an upcoming time period. A dashboard is provided that summarizes and visualizes quantitative metrics and other employee information and provides tools for creating a retention plan for particular employees. When selecting actions for a retention plan, an employee profile is updated to reflect the action and re-analyzed to provide a quantitative metric describing the net effect of the action on employee retention.

Abstract: Systems and methods for effecting secure transactions are described. A processing device, when executing computer-executable instructions: receives from a requesting entity computing system a transaction request for a payload. The transaction request is transmitted to delivery entity computing system associated with a delivery entity identifier and geographic location. An encryption key, random number and a unique request identifier are generated and transmitted to requesting and delivery entity computing systems. In response to receiving a delivery transaction confirmation from the delivery entity computing system, the processing device verifies the secure transaction. After receiving a requestor transaction confirmation from the requesting entity computing system (indicating a verified transfer of the payload), a payload reimbursement is transferred to a delivery transaction account from a requestor transaction account.

Abstract: Systems and methods are provided to ingest data objects from a flat file server for use in one or more system operations including providing a renderable data object to a user and updating a data item database. As described, the ingestion system includes an ingestion module, a flat file module, a compliance module, and a deduplication module wherein the modules together ingest a flat file data object, parse and process a renderable data object from the flat file data object, and store the renderable data object in a renderable object database.

Abstract: There is disclosed system for oxygenating a patient in relation to anaesthesia using high flow gas delivery. The system has a flow source, and a controller for determining oxygenation requirements of the patient before or during anaesthesia. A method of oxygenating a patient in relation to anaesthesia using high flow gas delivery is also disclosed. The method determines oxygenation requirements of the patient before or during anaesthesia.

Abstract: In one aspect, a movable barrier operator system is provided that includes a motor configured to be coupled to a movable barrier. The motor has a power rating indicative of a minimum power to be supplied to the motor in order for the motor to move the movable barrier. The system further includes an external power supply configured to connect to an electrical outlet. The external power supply has a plurality of outputs each having a power rating indicative of a maximum power the output supplies, the output power rating being less than the motor power rating. The movable barrier operator system includes combiner circuitry configured to combine power from the outputs of the external power supply and provide the combined power to the motor. The system further includes a monitoring circuit configured to detect a fault condition of any of the outputs of the external power supply.

Abstract: An electric pushback vehicle includes a frame having a forward portion and a rear portion. The vehicle further includes front drive axle and a rear drive axle configured to communicate power to ground engaging members. A traction battery is housed within the electric pushback vehicle and provides electric power to an electric motor to drive an output shaft. A transmission is connected to receive mechanical power from the electric motor through a torque converter.

Abstract: Systems and methods for using machine learning to determine product offers for individuals are disclosed. According to certain aspects, the systems and methods may determine, using a machine learning model and based on a set of products purchased by a user, a set of digital offers associated with an additional set of products to provide to the user. The user may redeem any of the digital offers, and the systems and methods may use any additional product purchase information to update the machine learning model for use in subsequent analyses.

Abstract: A propulsion system for an aircraft can include an electric power source and an electric propulsion assembly having an electric motor and a propulsor. The propulsor can be powered by the electric motor. An electric power bus can electrically connect the electric power source to the electric propulsion assembly. The electric power source can be configured to provide electrical power to the electric power bus. An inverter converter controller can be positioned along the electric power bus and can be electrically connected to the electric power source at a location downstream of the electric power source and upstream of the electric propulsion assembly.

Abstract: A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways comprising: a cushion member that includes a retaining structure and a seal-forming structure permanently connected to the retaining structure; a frame member attachable to the retaining structure; and a positioning and stabilising structure attachable to the frame member.

Abstract: The present invention relates to a rotor of an electric machine for use in an aircraft. By forming the shaft of the rotor such that it performs, at least partially, the function of the back iron, components of the rotor can be combined. Further, by forming the rotor components in this manner, an internal shaft with an increased diameter can be used to provide a rotor with greater stiffness than equivalent prior art devices.

Abstract: A conveyor assembly for raising and feeding debris such as fallen branches from an orchard floor to a processor such as a wood-chipper is provided. The conveyor assembly comprises a body including a floor having a leading end for location adjacent ground level and a trailing end for location above the leading end in use. A ground contact arrangement is located toward the leading end extends beneath the leading end to thereby raise the leading end above ground level. A powered leading feed roller is disposed adjacent the leading end of the floor to direct members from ground on to the floor. A powered, primary infeed roller is located rearward the leading infeed roller and is arranged to move toward and away from the floor to accommodate members between said roller and the floor and urge the members, such as fallen branches rearward for entry into an inlet of the wood-chipper.

Abstract: A single pass inkjet printer that utilizes a modular printing system with one or more self-contained printing modules, where each printing module is easy to remove and replace from a large printing machine, thus resulting in an overall system that is easy to service and maintain Each module is a self-contained printer including an ink supply, printhead drive electronics, and printhead assembly in order to provide one color or fluid of inkjet printing capability. Each module includes a precise three-point compliant self-aligning mount system to obtain accurate printhead positioning, and a unique integrated printhead tending system that includes a compact movable vacuum knife for cleaning the printheads, and a printhead capping station for sealing and protecting the printheads from the ambient environment when not in use.

Abstract: A liquid delivery system cap device is provided. In some embodiments, an example cap device includes a body defining a cavity configured to receive at least a portion of a liquid delivery device, and a sensor carriage movable within the cavity and including a first sensor. The sensor carriage may be movable between a first position and a second position relative to the cavity while the liquid delivery device is in a fixed positon relative to the cavity.