Patents by Inventor Anthony Dominic Keefe

Anthony Dominic Keefe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Materials and methods for the generation of fully 2?-modified nucleic acid transcripts
    Patent number: 8105813
    Abstract: Materials and methods are provided for producing aptamer therapeutics having fully modified nucleotide triphosphates incorporated into their sequence.
    Type: Grant
    Filed: June 30, 2006
    Date of Patent: January 31, 2012
    Assignee: Archemix Corp.
    Inventors: John L. Diener, Anthony Dominic Keefe, Kristin Thompson, Chunhua Wang, Shuhao Zhu
  • Materials and methods for the generation of transcripts comprising modified nucleotides
    Patent number: 8101385
    Abstract: Materials and methods are provided for producing aptamer therapeutics having modified nucleotide triphosphates incorporated into their sequence.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: January 24, 2012
    Assignee: Archemix Corp.
    Inventors: Sharon Cload, John L. Diener, Anthony Dominic Keefe, Kristin Thompson
  • Materials and methods for the generation of transcripts comprising modified nucleotides
    Publication number: 20100120024
    Abstract: Materials and Methods are provided for producing aptamer therapeutics having modified nucleotide triphosphates incorporated into their sequence.
    Type: Application
    Filed: December 21, 2007
    Publication date: May 13, 2010
    Inventors: Sharon Cload, John L. Diener, Anthony Dominic Keefe, Kristin Thompson
  • Nucleic acid ligands specific to immunoglobulin E and their use as atopic disease therapeutics
    Patent number: 7579450
    Abstract: The invention discloses aptamers capable of binding to Immunoglobulin E (“IgE”) useful as therapeutics in and diagnostics of atopic disease and/or other diseases or disorders in which IgE has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to IgE.
    Type: Grant
    Filed: April 26, 2005
    Date of Patent: August 25, 2009
    Assignee: Archemix Corp.
    Inventors: Paula Burmeister, Sharon Cload, John L. Diener, Anthony Dominic Keefe, Sara Chesworth Keene, Markus Kurz, H. A. Daniel Lagassé, Harold Nicholas Marsh, Pooja Sawhney, Chunhua Wang
  • Compositions and methods for in vivo SELEX
    Publication number: 20090081679
    Abstract: The invention describes methods for the in vivo selection of oligonucleotides, preferably aptamers, that persist in biological compartments. In one embodiment, the biological compartment comprises at least one tissue which, in a preferred embodiment, is the blood within the circulatory system of a living mammal. The invention also contemplates oligonucleotides, preferably aptamers, selected through in vivo SELEX that may be linked to therapeutic or diagnostic compositions including other oligonucleotides.
    Type: Application
    Filed: July 21, 2008
    Publication date: March 26, 2009
    Inventors: Anthony Dominic Keefe, Charles Wilson, Chunhua Wang
  • Aptamer-mediated intracellular delivery of oligonucleotides
    Publication number: 20080214489
    Abstract: Compositions and methods to mediate the intracellular and sub-cellular delivery of therapeutic, diagnostic and imaging agents, such as oligonucleotides. The compositions of the invention include nucleic acid conjugates comprising a delivery aptamer that is connected to an oligonucleotide. The delivery aptamer may be connected directly to the oligonucleotide, or may be connected indirectly to the oligonucleotide, such as through a linker. The oligonucleotide may be either a therapeutic, diagnostic or imaging oligonucleotide. The methods of the invention are used to increase potency, or alter distribution, half-life, metabolic fate, toxicity and other characteristics.
    Type: Application
    Filed: March 12, 2008
    Publication date: September 4, 2008
    Inventors: Anthony Dominic Keefe, Charles Wilson, Steven Shamah