Abstract: According to the disclosure, a target analyte detection cartridge includes a sample chamber into which sample is inserted, a metering chamber connected to the sample chamber to meter a predetermined amount of sample, a mixing chamber connected to the metering chamber to receive a magnet bead, and a waste chamber connected to the metering chamber. The metering chamber has one side connected to each of the sample chamber and the mixing chamber and another side connected to the waste chamber. A first pneumatic flow path to which pneumatic pressure is provided is connected to a waste flow path that joins the other side of the metering chamber to connect the metering chamber and the waster chamber.

Abstract: According to the disclosure, a target analyte detection cartridge includes a sample chamber into which sample is inserted, a metering chamber connected to the sample chamber to meter a predetermined amount of sample, a mixing chamber connected to the metering chamber to receive a magnet bead, and a waste chamber connected to the metering chamber. The metering chamber has one side connected to each of the sample chamber and the mixing chamber and another side connected to the waste chamber. A first pneumatic flow path to which pneumatic pressure is provided is connected to a waste flow path that joins the other side of the metering chamber to connect the metering chamber and the waster chamber.

Abstract: According to the disclosure, a target analyte detection cartridge includes a sample chamber into which sample is inserted, a metering chamber connected to the sample chamber to meter a predetermined amount of sample, a mixing chamber connected to the metering chamber to receive a magnet bead, and a waste chamber connected to the metering chamber. The metering chamber has one side connected to each of the sample chamber and the mixing chamber and another side connected to the waste chamber. A first pneumatic flow path to which pneumatic pressure is provided is connected to a waste flow path that joins the other side of the metering chamber to connect the metering chamber and the waster chamber.

Abstract: A valve can include a solenoid coil, a plunger having a core configured to respond to a magnetic field generated by the solenoid coil, and a valve disc. The valve disc can be positioned at a head of the core and configured to cushion impact when the valve is closed. A projection can be positioned and configured to cushion impact when the valve is opened. The valve can be used in an air bed system in fluid connection between an air pump and an inflatable air chamber of a mattress.

Abstract: An electric pushback vehicle includes a frame having a forward portion and a rear portion. The vehicle further includes front drive axle and a rear drive axle configured to communicate power to ground engaging members. A traction battery is housed within the electric pushback vehicle and provides electric power to an electric motor to drive an output shaft. A transmission is connected to receive mechanical power from the electric motor through a torque converter.

Abstract: An improved exhaust system and method for an apparatus that removes support material from additively manufactured parts is disclosed. The apparatus includes an enclosed chamber in which the additively manufactured parts are placed. A heated detergent fluid is sprayed at the additively manufactured parts. The improved exhaust system exhausts heated air from the chamber. The improved exhaust system includes an exhaust channel having an inlet end open to the chamber through which heated air from the chamber is caused to flow. Relatively cooler air is caused to flow across the outside of the exhaust channel. When the heated air from the chamber encounters the exhaust channel across which the relatively cooler air is caused to flow, evaporated fluids in the heated air condense and fall back into the chamber. The improved exhaust system can be retrofitted onto older models of the support removal apparatus that do not have the improved exhaust system.

Abstract: The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

Abstract: The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R7, and R8 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compound, and methods of using the Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

Abstract: A flow apparatus for measuring at least one biophysical property of one or more components is provided. The apparatus comprises one or more microfluidic devices. Each microfluidic device comprises: a sample channel having a sample inlet port for introducing a sample fluid flow comprising one or more components at a first flow rate into an elongate distribution channel, an auxiliary channel having an auxiliary inlet port for introducing an auxiliary fluid flow at a second flow rate into the elongate distribution channel. The distribution channel is configured to enable a lateral distribution of the components from the sample fluid flow into the auxiliary fluid flow. Each microfluidic device further comprises two or more capillary channels provided downstream and in fluid communication with the distribution channel, at least one outlet port provided downstream of each of the capillary channels.

Abstract: An article formed of a metal alloy is covered at least partially with a metal hydride and a shell metal to form an assembly. Load is applied to the assembly and the assembly is heated. The shell metal deforms around the article and the metal hydride and forms a gas proof seal. The metal hydride thermally decomposes to form hydrogen gas. At least a portion of the hydrogen gas dissociates and moves as monoatomic hydrogen into the article. The metal alloy can be a zirconium metal alloy, the metal hydride can be a zirconium metal hydride, and the shell metal can be substantially copper.

Abstract: A system having a guidance module to obtain a travel path from an agricultural machine to a target. The guidance module including a perception module to determine target line that extends from the machine to the target, and obstacle detection module to detect an obstacle in the first target line, the obstacle having an obstacle boundary that intersects the target line. The guidance module including a mitigation module to obtain a mitigation path around the obstacle based on the target line and the obstacle boundary, the mitigation path including a mitigation segment. The mitigation module including an entrance module configured to determine a starting position of the mitigation path based on a second target line and an exit module configured to determine the ending position of the mitigation path based on a third target line. The guidance module including convergence module to combine the mitigation path with the travel path.

Abstract: A shower nozzle assembly includes a shower nozzle, a nozzle attachment, and a bayonet connector. The shower nozzle has a water inlet opening and a water outlet part spaced from the water inlet opening, with the water outlet opening being configured to direct a flow of water out of the shower nozzle. The nozzle attachment has a through bore configured to receive the water outlet part therein. The bayonet connection is operative to secure the nozzle attachment to the shower nozzle, and includes a radial projection and a female bayonet receptor part configured to receive the radial projection therein to secure the shower nozzle to the nozzle attachment.

Abstract: A fluid flow controller for introducing fluids into a microfluidic device is provided. The fluid flow controller comprising, at least one high resistance fluid pathway provided between an inlet port and a connection port; at least one low resistance fluid pathway between the inlet and connection port; and at least one valve configured to enable fluid flow through the high resistance fluid pathway, the low resistance fluid pathway or both.

Abstract: A device for controlling a fluid flow in an array of fluid pathways on a microfluidic chip is provided. The device comprising: two or more resistors provided upstream of the chip wherein each upstream resistor is configured to provide a resistance at an upstream end of a fluid pathway; two or more resistors provided downstream of the chip wherein each downstream resistor is configured to provide a resistance at a downstream end of a fluid pathway, wherein the values of the resistances are selected in order to control a proportion of fluid that flows through each fluid pathway.

Abstract: A single-layer valve is provided. The valve comprises a microfluidic pathway at least partially defined by a flexible membrane which is configured to deform when subjected to an actuation torque, and a discontinuity bounded by a first surface. The length of the discontinuity is constant across the full width of the first surface. The valve is configured such that the actuation torque on the membrane is larger in a first direction than a second direction substantially opposite to the first direction.

Abstract: A fluidic system is provided. The system comprises: a rigid housing (12), a plurality of flexible reagent containers (14) contained within the housing (12); wherein each reagent container (14) has a connection port (16) through which a reagent can flow, in use, on the application of pressure. The system further comprises a single pressure source (18) configured to apply pressure to the interior of the rigid housing (12); a microfluidic device configured to analyse one or more fluids provided from the plurality of reagent containers; and a plurality of channels (20) configured to transfer fluid from the plurality of reagent containers (14) to the microfluidic device. The ratio of resistances provided by a combination of the connection ports and the plurality of channels dictates the ratio of flow rates of the reagents. The claimed system allows for an accurate control of the various reagent flow rates while minimizing fluctuations in the relative flow rates.

Abstract: A device for controlling a fluid flow in an array of fluid pathways on a microfluidic chip is provided. The device comprising: two or more resistors provided upstream of the chip wherein each upstream resistor is configured to provide a resistance at an upstream end of a fluid pathway; two or more resistors provided downstream of the chip wherein each downstream resistor is configured to provide a resistance at a downstream end of a fluid pathway, wherein the values of the resistances are selected in order to control a proportion of fluid that flows through each fluid pathway.

Abstract: In one embodiment, the invention can be a method for manager-to-employee communication, the method including receiving comment data from employee devices of employees of an organization, the comment data indicating employee comments to a survey topic; receiving contact-me data from a manager device indicating contact-me requests, the contact-me requests indicating that the manager desires the employees to contact the manager directly regarding the employee comments to the survey topic; receiving contact-me response data from the employee devices indicating whether the employees will contact the manager directly; and generating a manager rating based on the saved contact-me response data.

Abstract: An article formed of a metal alloy is covered at least partially with a metal hydride and a shell metal to form an assembly. Load is applied to the assembly and the assembly is heated. The shell metal deforms around the article and the metal hydride and forms a gas proof seal. The metal hydride thermally decomposes to form hydrogen gas. At least a portion of the hydrogen gas dissociates and moves as monoatomic hydrogen into the article. The metal alloy can be a zirconium metal alloy, the metal hydride can be a zirconium metal hydride, and the shell metal can be substantially copper.

Abstract: In one embodiment, the invention can be a method of protecting confidentiality in a real-time survey, the method including receiving from each of a plurality of organization respondents a real-time response to a survey topic; receiving an indication of an organizational change affecting a first member of the organization, the organizational change comprising the first member departing or joining a first department, the first department comprising a plurality of first department respondents, the plurality of first department respondents being a first subset of the plurality of organization respondents; defining a first safe group comprising a first subset of the plurality of first department respondents, the first safe group having first safe group responses to the survey topic; and providing a response report for at least the first department, the response report excluding the first safe group responses.