Patents by Inventor Anthony F. Shields

Anthony F. Shields has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphoramidate derivatives of FAU
    Patent number: 7888330
    Abstract: The present invention provides phosphoramidate derivatives of a furanosyluracil analog, FAU, that can effectively deliver FAU monophosphate, or a derivative thereof, intracellularly. FAU-Phosphoramidate diesters can bypass the first step of phosphorylation and be activated intracellularly so as to be converted to nucleoside monophosphates. This results in improved formation of nucleoside triphosphates, and higher incorporation into DNA. The compounds of the invention can be used to treat cancer.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: February 15, 2011
    Assignee: Wayne State University
    Inventors: Anthony F. Shields, Jiri Zemlicka, Sridhar Nimmagadda
  • Phosphoramidate Derivatives of Fau
    Publication number: 20080292553
    Abstract: The present invention provides phosphoramidate derivatives of a furanosyluracil analog, FAU, that can effectively deliver FAU monophosphate, or a derivative thereof, intracellularly. FAU-Phosphoramidate diesters can bypass the first step of phosphorylation and be activated intracellularly so as to be converted to nucleoside monophosphates. This results in improved formation of nucleoside triphosphates, and higher incorporation into DNA. The compounds of the invention can be used to treat cancer.
    Type: Application
    Filed: November 9, 2006
    Publication date: November 27, 2008
    Inventors: Anthony F. Shields, Jiri Zemlicka, Sridhar Nimmagadda