Patents by Inventor Anthony Filiano

Anthony Filiano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYSTEMS AND METHODS FOR PROMOTING REMYELINATION WITH FACTORS DERIVED FROM UMBILICAL CORD BLOOD MACROPHAGES
    Publication number: 20230355669
    Abstract: Compositions and methods of promoting myelination in neurons are disclosed. The compositions include factors present in an umbilical cord blood derived macrophage cell population culture medium which can promote maturation of oligodendrocytes to promote myelination of neurons. Clinal and non-clinical uses of the compositions are also disclosed.
    Type: Application
    Filed: May 5, 2023
    Publication date: November 9, 2023
    Applicant: Duke University
    Inventors: Anthony Filiano, Li Xu, Joanne Kurtzberg
  • Compositions and methods of enhancing the homing and/or engraftment of hematopoietic cells in the central nervous system
    Patent number: 11679104
    Abstract: The present disclosure relates to compositions and methods for enhanced engraftment of hematopoietic cells into the brain, and to therapeutic methods of treating central nervous system (CNS) diseases and disorders in subjects where replacing CNS pot macrophages (including microglia) and other tissue-resident macrophages with donor cells would be beneficial. In particular, the present disclosure relates to the use of a microglia depleting agent to enhance engraftment of hematopoietic-derived macrophages in the brain of a subject undergoing hematopoietic cell transplantation, to treat a subject suffering from a leukodystrophy and undergoing hematopoietic cell transplantation, to treat a subject suffering from a disease mediated by microglial dysfunction and undergoing hematopoietic cell transplantation, and to related methods. The present disclosure also relates to detection within cell populations of beMc? and microglia signatures.
    Type: Grant
    Filed: December 15, 2018
    Date of Patent: June 20, 2023
    Assignees: Duke University, University of Virginia Patent Foundation
    Inventors: Anthony Filiano, Joanne Kurtzberg, Jonathan Kipnis
  • Compositions and Methods of Enhancing the Homing and/or Engraftment of Hematopoietic Cells in the Central Nervous System
    Publication number: 20200316039
    Abstract: The present disclosure relates to compositions and methods for enhanced engraftment of hematopoietic cells into the brain, and to therapeutic methods of treating central nervous system (CNS) diseases and disorders in subjects where replacing CNS pot macrophages (including microglia) and other tissue-resident macrophages with donor cells would be beneficial. In particular, the present disclosure relates to the use of a microglia depleting agent to enhance engraftment of hematopoietic-derived macrophages in the brain of a subject undergoing hematopoietic cell transplantation, to treat a subject suffering from a leukodystrophy and undergoing hematopoietic cell transplantation, to treat a subject suffering from a disease mediated by microglial dysfunction and undergoing hematopoietic cell transplantation, and to related methods. The present disclosure also relates to detection within cell populations of beMc? and microglia signatures.
    Type: Application
    Filed: December 15, 2018
    Publication date: October 8, 2020
    Inventors: Anthony Filiano, Joanne Kurtzberg, Jonathan Kipnis