Abstract: The invention relates to a method of creating a human blood-brain barrier (BBB) model from the differentiation of human pluripotent stem cells (hPSCs), wherein the BBB exhibits sustained transendothelial electrical resistances (TEER) over 2000 ?·cm2 for at least 3 days after seeding.

Abstract: The invention relates to a method of creating a human blood-brain barrier (BBB) model from the differentiation of human pluripotent stem cells (hPSCs), wherein the BBB exhibits sustained transendothelial electrical resistances (TEER) over 2000 ?·cm2 for at least 3 days after seeding.

Abstract: A method of investigating a sample (breast tissue) (27), the sample comprising at least a first material (normal breast tissue) in order to determine they presence of at least one further material (cancerous tissue), the method comprising the steps of: Irradiating the sample with electromagnetic radiation in the range from 25 GHz to 100 THz; Detecting radiation reflected from the sample; Determining a parameter related to the amplitude of the radiation, which is reflected from the sample, in the time domain; Analysing the parameter derived in step (c) in order to determine if the sample further comprises the at least one further material wherein the irradiating and reflected radiation passes through a (z-cut quartz) window member (43) having a refractive index that falls between the refractive indices of the at least first and at least one further materials

Abstract: Imaging techniques of pharmaceutical preparations such as tablets are disclosed. The techniques combine the measurement of reflected/transmitted terahertz radiation originating from within the tablet and data analysis localised in frequency and time in order to enable a three dimensional image indicating composition to be obtained.

Abstract: A method of executing a program compiled for a base instruction set architecture different than a native instruction set architecture, on a native machine by organizing a runtime system module into at least a low level domain, a medium level domain, and a high level domain. A memory buffer referred to as a backing store is created to correspond to a register stack and have a one-to-one mapping with the register stack. The invention initializes a beginning of the backing store to contain user-visible register values which constitute base instruction set architecture register values, and sets a virtual instruction pointer to a current instruction which is to be executed. The method of the present invention executes a start routine for forcing a reload of the user-visible register values from the backing store to the register stack and returns to the low level domain to perform a lookup operation in a translation lookaside buffer.

Abstract: A coating feed apparatus and method (10) for depositing a uniform overflow curtain-like layer of coating composition (c) to a gravure surface (14) has a reservoir (14) and means for delivering the coating composition to the gravure surface (14). The reservoir (14) has a base (24) sloped upwardly from a rear wall (22). A widthwise lip (40) is directed generally downwardly towards the gravure surface (14). Widthwise lip (40) and the undercut portion (48) together enable the coating composition (c) exiting the outlet end (26) of the reservoir (12) to overflow downwardly across widthwise lip (40) in a uniform curtain-like layer (32) towards the gravure surface (14) without creating a backflow of coating composition along the base (24).

Abstract: An apparatus for translating a multiple user program into a native machine code to run on a native computer hardware having memory and an operating system that is capable of detecting whether the program has an instruction set architecture different from a native instruction set architecture. The memory has a source file including the program to be translated. At least one source code module is defined as including a plurality of blocks of code mapped to the memory by the operating system. The blocks have one or more source instructions, with each block beginning with one of the source instructions and ending with a branch or a target of the branch. A virtual instruction pointer points to one of the source instructions to be executed. One or more source instructions are dynamically translated and executed, and a profile data is produced. A shared translation file is ultimately created for the source code module using the profile data.

Abstract: A method of operating a two-stroke cycle internal combustion engine having at least one exhaust port communicating with each combustion chamber of the engine and an exhaust valve operably associated with at least one said exhaust port to control the timing of the opening and the flow area through said exhaust port between maximum and minimum values, the method comprising advancing the timing of the opening of the exhaust port in response to idle or low load operation to the maximum extent to maximize the flow area through the exhaust port. Other engine management operations disclosed and claimed include: positioning the exhause valve to reduce the flow area to the minimum extent on cessation of operation of the engine, and impacting the exhaust valve against the limits defining the maximum and minimum values of valve movement to promote dislodgement of carbon deposits.

Abstract: A coating feed apparatus and method (10) for depositing a uniform overflow curtain-like layer of coating composition (c) to a gravure surface (14) has a reservoir (14) and means for delivering the coating composition to the gravure surface (14). The reservoir (14) has a base (24) sloped upwardly from a rear wall (22). A widthwise lip (40) is directed generally downwardly towards the gravure surface (14). Widthwise lip (40) and the undercut portion (48) together enable the coating composition (c) exiting the outlet end (26) of the reservoir (12) to overflow downwardly across widthwise lip (40) in a uniform curtain-like layer (32) towards the gravure surface (14) without creating a backflow of coating composition along the base (24).