Abstract: This disclosure describes compounds of Formula (I), stereoisomers, side compounds thereof, pharmaceutical compositions and methods of manufacturing such compounds, using silylation reagents and producing compositions and products made using such methods. More particularly, this disclosure describes manufacture of trofinetide and side products, compositions and products containing such compounds, for pharmaceutical uses to treat neurodegenerative or neurodevelopmental disorders.

Abstract: A medical device includes a handle, including a movable body. The medical device also includes a shaft extending from the handle, and an electrode at a distal end of the shaft. Movement of the movable portion of the handle controls a position of the electrode relative to the distal end of the shaft. At least a portion of the shaft includes a braiding.

Abstract: Example medical devices are disclosed. An example medical device includes an elongate member having a proximal end region, a distal end region and an outer surface. The medical device also includes a plurality of filaments braided together in a first braided pattern along a first braided region of the elongate member, wherein the plurality of filaments extend continuously to a second braided region along the elongate member, wherein the plurality of filaments along the second braided region form a second braided pattern different from the first braided pattern.

Abstract: A system and methods for generating dynamic market pricing that is fair for both publishers and advertisers and the use of the pricing in real-time auctions. When a user views content over the internet, an online publisher provides content to the user with executable instructions, which notify an advertisement source that there is an impression for filling by an advertiser. The impression is submitted to a real-time bidding market for competing advertisers to bid to fill the impression with an advertisement. The system and methods generate dynamic pricing for the individual competing advertisers and use the dynamic pricing to compare advertiser bids to determine a highest or winning bid and a clearing price associated with the highest or winning bid.

Abstract: There are provided systems and methods for an interface widget tool for automatic QR code generation and display without application launching. A user may engage in a transaction with another user, such as a purchase of goods, services, or other items a merchant at a merchant location using machine-readable codes. A machine-readable code may be provided via a mobile device of a user. In order to provide faster and more efficient code generation, an interface widget or other tool may be provided, which, on selection, may execute API calls to a server of a transaction processor. The transaction processor may generate a code without requiring the user to go through a code generation and processing flow in a corresponding application. The code may be limited in validity and may be presented via the widget. Once scanned, the code may provide encoded data for a financial instrument.

Abstract: Techniques are disclosed relating to ensuring data integrity between database objects. A computer system may receive a data integrity request for a first set of database tables. The computer system may generate at least two work items that correspond to respective data cell groups in the first set of database tables. The computer system may then cause a plurality of processes to perform the at least two work items to generate a first plurality of hash values that includes hash values for the respective data cell groups. The first plurality of hash values may be usable to compare with corresponding ones of a second plurality of hash values generated based on corresponding data cell groups in a second set of database tables replicated from the first set of database tables.

Abstract: A clip for reducing a dimension of an opening in tissue may include a continuous member having a plurality of legs and a plurality of preformed bends connecting adjacent legs, wherein the plurality of legs form: a first group having two protrusions; a second group having two protrusions; and a third group having two protrusions, wherein each protrusion of each group includes two legs of the continuous member and a corresponding preformed bend connecting the two legs, and each protrusion of each group extends from a region adjacent a first end of the clip to a region adjacent a second end of the clip.

Abstract: Material transport equipment includes first and second pairs of main wheels and first and second pairs of extension wheels rotatably attached to a frame. The main wheels have a diameter greater than the extension wheels and are spaced further apart than the extension wheels. The main wheels and the extension wheels are adapted to roll on the rails of a main section and of an extension, respectively, of an extension ladder. The equipment may be used as a hand truck for carrying a payload on ground wheels rolling on the ground. The apparatus may then be leaned to position main wheels of the apparatus onto rails of a main section of an extension ladder. Extension wheels on the apparatus move onto rails of the extension of the ladder as the apparatus moves up from the main section onto the extension using a rope or cable.

Abstract: Techniques are disclosed relating to ensuring data integrity between database objects. A computer system may receive a data integrity request for a first set of database tables. The computer system may generate at least two work items that correspond to respective data cell groups in the first set of database tables. The computer system may then cause a plurality of processes to perform the at least two work items to generate a first plurality of hash values that includes hash values for the respective data cell groups. The first plurality of hash values may be usable to compare with corresponding ones of a second plurality of hash values generated based on corresponding data cell groups in a second set of database tables replicated from the first set of database tables.

Abstract: A chemical dispensing system for delivering a chemical dose into a water resource is provided herein. The system includes a dispensing housing, a support feature, and an electrical circuit. The dispensing housing includes at least one compartment that is adapted to retain a chemical dose. The compartment is substantially sealable from an ambient environment that is outside of the compartment. The compartment is independently openable and closable to directly expose the compartment to the ambient environment and enable release of contents retained therein in the open position and to substantially prevent release of the contents retained therein in the closed position. The support feature facilitates suspension of the dispensing housing above a surface of the water resource. Opening of the compartment is controllable through the electrical circuit.

Abstract: Embodiments herein relate to non-invasive bladder cancer detection systems and methods. In an embodiment, a method for detecting a disease state in a subject is included. The method includes obtaining a liquid biological sample from the subject and placing it into a container and contacting the liquid biological sample with a first chemical sensor element, where the first chemical sensor element can include a plurality of discrete graphene varactors. The method can include sensing and storing capacitance of each of the discrete graphene varactors to obtain a first sample data set. Other embodiments are also included herein.

Abstract: Example medical devices are disclosed. An example medical device includes an elongate member having a proximal end region, a distal end region and an outer surface. The medical device also includes a plurality of filaments braided together in a first braided pattern along a first braided region of the elongate member, wherein the plurality of filaments extend continuously to a second braided region along the elongate member, wherein the plurality of filaments along the second braided region form a second braided pattern different from the first braided pattern.

Abstract: A device may include a catheter and a support tube. The catheter includes a lumen extending therethrough. The catheter is sized and shaped to extend through an endoscopic shaft to a target tissue within a living body. The lumen is sized and shaped for receiving a puncturing device therethrough. The catheter includes a first catheter portion distal to a second catheter portion. The first and second catheter portions are formed from different materials. The first catheter portion has a flexible curved distal end. The tube is fixed about an outer surface of a proximal end of the first catheter portion and an outer surface of a distal end of the second catheter portion.

Abstract: A system and methods for generating dynamic market pricing that is fair for both publishers and advertisers and the use of the pricing in real-time auctions. When a user views content over the internet, an online publisher provides content to the user with executable instructions, which notify an advertisement source that there is an impression for filling by an advertiser. The impression is submitted to a real-time bidding market for competing advertisers to bid to fill the impression with an advertisement. The system and methods generate dynamic pricing for the individual competing advertisers and use the dynamic pricing to compare advertiser bids to determine a highest or winning bid and a clearing price associated with the highest or winning bid.

Abstract: The present invention relates to compositions comprising oligonucleotides, specifically SMAD7 antisense oligonucleotides, and methods for preparing the same.

Abstract: A system and methods for generating dynamic market pricing that is fair for both publishers and advertisers and the use of the pricing in real-time auctions. When a user views content over the internet, an online publisher provides content to the user with executable instructions, which notify an advertisement source that there is an impression for filling by an advertiser. The impression is submitted to a real-time bidding market for competing advertisers to bid to fill the impression with an advertisement. The system and methods generate dynamic pricing for the individual competing advertisers and use the dynamic pricing to compare advertiser bids to determine a highest or winning bid and a clearing price associated with the highest or winning bid.

Abstract: A chemical dispensing system for delivering a chemical dose into a water resource is provided herein. The system includes a dispensing housing, a support feature, and an electrical circuit. The dispensing housing includes at least one compartment that is adapted to retain a chemical dose. The compartment is substantially sealable from an ambient environment that is outside of the compartment. The compartment is independently openable and closable to directly expose the compartment to the ambient environment and enable release of contents retained therein in the open position and to substantially prevent release of the contents retained therein in the closed position. The support feature facilitates suspension of the dispensing housing above a surface of the water resource. Opening of the compartment is controllable through the electrical circuit.

Abstract: A method is employed in association with a communication session over a peer-to-peer network between a first node associated with a first session participant and a second node associated with a second session participant. In the method, identification information identifying the second session participant is received. Profile information descriptive of the second session participant is gathered using the identification information. The communication session is conducted using the profile information descriptive of the second session participant.

Abstract: Provided herein are compositions including the crystalline forms of (1E, 4E)-2-amino-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide (“Compound A”), methods of making the crystalline forms, and methods of using the crystalline forms for the treatment of diseases, including, for example, cancer.

Abstract: The present invention relates to a tank piston with an improved seal having a cap, a body attached to the periphery of the cap, a circumferential channel adjacent to the periphery of the cap and an annular seal held within the channel by an annular sheet. In one aspect of the invention the annular sheet secures the seal within the channel and is attached to the piston by a ring proximate to the periphery of the cap and a ring proximate to the back side of the circumferential channel. In another aspect of the invention the annular sheet is made from a friction reducing material and enables the piston to more easily move within the tank and subsequently extends the lifespan of the seal. Additionally, the annular sheet is fitted to the seal and attached above the front sidewall of the channel.