Abstract: Mass spectrometry systems include a core featuring an ion source, an ion trap, and an ion detector connected along a gas path, a pressure regulation subsystem connected to the gas path and configured to regulate a gas pressure in the gas path, a sample pre-concentrator connected to the gas path, where the sample pre-concentrator includes an adsorbent material, and a controller connected to the sample pre-concentrator, where during operation of the system, the controller is configured to heat sample particles adsorbed on the adsorbent material to desorb the particles from the adsorbent material and introduce the desorbed particles into the gas path, and a pressure difference between a gas pressure in the sample pre-concentrator and a gas pressure in at least one of the ion source, the ion trap, and the ion detector when the desorbed particles are introduced into the gas path is 50 mTorr or less.

Abstract: Mass spectrometry systems include a core featuring an ion source, an ion trap, and an ion detector connected along a gas path, a pressure regulation subsystem connected to the gas path and configured to regulate a gas pressure in the gas path, a sample pre-concentrator connected to the gas path, where the sample pre-concentrator includes an adsorbent material, and a controller connected to the sample pre-concentrator, where during operation of the system, the controller is configured to heat sample particles adsorbed on the adsorbent material to desorb the particles from the adsorbent material and introduce the desorbed particles into the gas path, and a pressure difference between a gas pressure in the sample pre-concentrator and a gas pressure in at least one of the ion source, the ion trap, and the ion detector when the desorbed particles are introduced into the gas path is 50 mTorr or less.

Abstract: A connector for joining a first hollow structure to the side wall of a second hollow structure, the connector comprising a first component comprising an inner collar; a hollow body; and a graft mounted to the inner collar and forming a conduit through the hollow body and the inner collar; and a second component comprising an outer collar and a hollow body, the hollow body of the second component being sized for coaxial disposition over the hollow body of the first component so that the outer collar of the second component can be adjustably positioned relative to the inner collar of the first component and so that the conduit of the graft provides fluid communication between (i) the region beyond the inner collar, and (ii) the region beyond the hollow body of the first component.

Abstract: Mass spectrometry systems include a core featuring an ion source, an ion trap, and an ion detector connected along a gas path, a pressure regulation subsystem connected to the gas path and configured to regulate a gas pressure in the gas path, a sample pre-concentrator connected to the gas path, where the sample pre-concentrator includes an adsorbent material, and a controller connected to the sample pre-concentrator, where during operation of the system, the controller is configured to heat sample particles adsorbed on the adsorbent material to desorb the particles from the adsorbent material and introduce the desorbed particles into the gas path, and a pressure difference between a gas pressure in the sample pre-concentrator and a gas pressure in at least one of the ion source, the ion trap, and the ion detector when the desorbed particles are introduced into the gas path is 50 mTorr or less.

Abstract: Apparatus for attaching a left ventricular assist device (LVAD) to a heart, the apparatus comprising: a connector conduit comprising: a distal end, a proximal end and a lumen extending between the distal end and the proximal end, wherein the distal end is configured to be inserted into a wall of the heart, and the proximal end is configured to receive the LVAD, whereby hemostasis is maintained during insertion of the connector conduit into the wall of the heart and during insertion of the LVAD into the proximal end of the connector conduit.

Abstract: Mass spectrometry systems include a core featuring an ion source, an ion trap, and an ion detector connected along a gas path, a pressure regulation subsystem connected to the gas path and configured to regulate a gas pressure in the gas path, a sample pre-concentrator connected to the gas path, where the sample pre-concentrator includes an adsorbent material, and a controller connected to the sample pre-concentrator, where during operation of the system, the controller is configured to heat sample particles adsorbed on the adsorbent material to desorb the particles from the adsorbent material and introduce the desorbed particles into the gas path, and a pressure difference between a gas pressure in the sample pre-concentrator and a gas pressure in at least one of the ion source, the ion trap, and the ion detector when the desorbed particles are introduced into the gas path is 50 mTorr or less.

Abstract: An implantable connector for suturelessly connecting a conduit to a hollow organ, the implantable connector comprising: a hollow expandable stent, wherein the hollow expandable stent comprises an internal skeleton and a blood-retaining membrane covering the internal skeleton, and wherein the hollow expandable stent is constructed so that it is capable of assuming (i) a diametrically-reduced state for insertion into an opening formed in the side wall of the hollow organ in order to create a first interference fit therewith, and (ii) a diametrically-expanded state for expanding against the side wall of the hollow organ in order to create a second, enhanced interference fit therewith.

Abstract: A connector for joining a first hollow structure to the side wall of a second hollow structure, the connector comprising a first component comprising an inner collar; a hollow body; and a graft mounted to the inner collar and forming a conduit through the hollow body and the inner collar; and a second component comprising an outer collar and a hollow body, the hollow body of the second component being sized for coaxial disposition over the hollow body of the first component so that the outer collar of the second component can be adjustably positioned relative to the inner collar of the first component and so that the conduit of the graft provides fluid communication between (i) the region beyond the inner collar, and (ii) the region beyond the hollow body of the first component.

Abstract: A connector for joining first and second hollow structures, comprising a fluid-constraining tube having a fluid-constraining neck extending therefrom, wherein the tube and the neck each comprise a lumen having first and second openings, the neck being joined to the tube such that fluid entering the first opening of the tube can exit the second opening of the tube, and fluid entering the first opening of the neck can exit the second opening of the tube; at least the portions of the tube adjacent to the first and second openings of the tube being biased radially outwardly so that they normally assume a radially-expanded configuration, but being capable of being restrained in a radially-contracted configuration, wherein the tube is sized so that, when it is in its radially-expanded configuration, it has an outer diameter which is larger than the inner diameter of the second hollow structure.

Abstract: A connector for joining a first hollow structure to the side wall of a second hollow structure, the connector comprising: a first component comprising: an inner collar for disposition within the interior of the second hollow structure, the inner collar having a toroidal configuration characterized by an outer perimeter and an inner perimeter, with the inner collar being flexible; a hollow body connected to the inner collar and upstanding therefrom, the hollow body of the inner collar being aligned with the inner perimeter of the inner collar; and a graft element mounted to the inner collar and forming a conduit extending through the hollow body and the inner perimeter of the inner collar, the graft being formed out of a fluid-retaining material; and a second component for disposition outside the second hollow structure, the second component comprising an outer collar and a hollow body connected to the outer collar, the outer collar having a toroidal configuration characterized by an outer perimeter and

Abstract: A connector for joining a first hollow structure to the side wall of a second hollow structure, the connector comprising: a fluid-constraining tube having a fluid-constraining neck extending therefrom, wherein the tube comprises a lumen having a first opening and a second opening and the neck comprises a lumen having a first opening and a second opening, the neck being joined to the tube so that the neck is in fluid communication with the tube intermediate the length of the tube, such that fluid entering the first opening of the tube can exit the second opening of the tube, and fluid entering the first opening of the neck can exit the second opening of the tube; at least the portions of the tube adjacent to the first opening of the tube and the second opening of the tube being biased radially outwardly so that they normally assume a radially-expanded configuration, but being capable of being restrained in a radially-contracted configuration, wherein the tube is sized so that, when it is in its radially-exp

Abstract: An implantable connector for suturelessly connecting a conduit to a hollow organ, the implantable connector comprising: a hollow expandable stent, wherein the hollow expandable stent comprises an internal skeleton and a blood-retaining membrane covering the internal skeleton, and wherein the hollow expandable stent is constructed so that it is capable of assuming (i) a diametrically-reduced state for insertion into an opening formed in the side wall of the hollow organ in order to create a first interference fit therewith, and (ii) a diametrically-expanded state for expanding against the side wall of the hollow organ in order to create a second, enhanced interference fit therewith.

Abstract: A leak detector includes a leak detector inlet to receive a test gas; a vacuum pump coupled to the leak detector inlet; a test gas sensing unit connected through a passage to the leak detector inlet; and a membrane that is permeable to the test gas disposed in the passage between the leak detector inlet and the test gas sensing unit, the membrane having a permeance to the test gas that varies by less than five percent over a temperature range of T0?20K to T0+20K, where T0 is a design temperature. In addition, methods are provided for making a composite membrane that includes a semi-permeable membrane and a porous membrane. Furthermore, a reference leak, which includes a composite membrane is provided.

Abstract: A leak detector includes a leak detector inlet to receive a test gas, a vacuum pump coupled to the leak detector inlet, a test gas sensing unit connected through a passage to the leak detector inlet, to sense the test gas, a membrane that is permeable to the test gas, the membrane disposed in the passage between the leak detector inlet and the test gas sensing unit, and a control mechanism to substantially terminate transmission of the test gas through the membrane in a time of 500 milliseconds or less. In other embodiments, the control mechanism substantially terminates transmission of the test gas through the membrane in a time of 100 milliseconds or less.

Abstract: A leak detector includes a leak detector inlet to receive a test gas; a vacuum pump coupled to the leak detector inlet; a test gas sensing unit connected through a passage to the leak detector inlet; and a membrane that is permeable to the test gas disposed in the passage between the leak detector inlet and the test gas sensing unit, the membrane having a permeance to the test gas that varies by less than five percent over a temperature range of T0?20K to T0+20K, where T0 is a design temperature. In addition, methods are provided for making a composite membrane that includes a semi-permeable membrane and a porous membrane. Furthermore, a reference leak, which includes a composite membrane is provided.

Abstract: A leak detector includes a leak detector inlet to receive a test gas; a vacuum pump coupled to the leak detector inlet; a test gas sensing unit connected through a passage to the leak detector inlet; and a membrane that is permeable to the test gas disposed in the passage between the leak detector inlet and the test gas sensing unit, the membrane having a permeance to the test gas that varies by less than five percent over a temperature range of T0?20 K to T0+20 K, where T0 is a design temperature. In addition, methods are provided for making a composite membrane that includes a semi-permeable membrane and a porous membrane. Furthermore, a reference leak, which includes a composite membrane is provided.

Abstract: A leak detector includes a leak detector inlet to receive a test gas, a vacuum pump coupled to the leak detector inlet, a test gas sensing unit connected through a passage to the leak detector inlet, to sense the test gas, a membrane that is permeable to the test gas, the membrane disposed in the passage between the leak detector inlet and the test gas sensing unit, and a control mechanism to substantially terminate transmission of the test gas through the membrane in a time of 500 milliseconds or less. In other embodiments, the control mechanism substantially terminates transmission of the test gas through the membrane in a time of 100 milliseconds or less.

Abstract: Scroll pumping apparatus includes a first scroll element and a second scroll element, a drive mechanism operatively coupled to the second scroll element for producing orbiting motion of the second scroll element relative to the first scroll element, and a synchronization device including a strip having connected, substantially flat sections, coupled between the first scroll element and the second scroll element. The synchronization device may have a generally square configuration.

Abstract: Vacuum pumping apparatus includes a pump frame, a stationary scroll element secured to the pump frame, the stationary scroll element including a stationary scroll blade, an orbiting scroll element including an orbiting scroll blade intermeshed with the stationary scroll blade, a motor secured to the pump frame, and a crankshaft coupled between the motor and the orbiting scroll element for producing orbiting movement of the orbiting scroll blade relative to the stationary scroll blade when the motor is energized. The crankshaft includes a first component having a first coefficient of thermal expansion and a second component having a second coefficient of thermal expansion.

Abstract: A vacuum pumping system includes a primary vacuum pump having an inlet for coupling to a system, and a secondary vacuum pump having an inlet coupled to the exhaust of the primary vacuum pump. The primary vacuum pump is an oil-free, positive displacement vacuum pump having multiple clearance seals between the inlet and the exhaust. The primary vacuum pump may be a scroll vacuum pump, and the secondary vacuum pump may be an oil-free diaphragm pump. The system may include a valve coupled to the exhaust of the primary vacuum pump and configured to couple the exhaust of the primary vacuum pump to an interpump exhaust in response to a selected condition, such as the pressure level at the exhaust of the primary vacuum pump.