Patents by Inventor Anthony G. M. Barrett

Anthony G. M. Barrett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4-[[(7-aminopyrazolo[1,5-a]pyrimidin-5-yl)amino]methyl]piperidin-3-ol compounds as CDK inhibitors
    Patent number: 11857552
    Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 4-[[(7-aminopyrazolo[1,5-a]pyrimidin-5-yl)amino]methyl]piperidin-3-ol compounds (referred to herein as “APPAMP compounds”) that, inter alia, inhibit (e.g., selectively inhibit) CDK (e.g., CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8, CDK9, CDK10, CDK11, CDK12, CDK13, etc.).
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: January 2, 2024
    Assignee: CARRICK THERAPEUTICS LIMITED
    Inventors: Ash Bahl, Ed Ainscow, Alexander Bondke, Anthony G. M. Barrett, Mihiro Sunose, Jason John Shiers, Kamaldeep Chohan
  • 4-[[(7-AMINOPYRAZOLO[1,5-A]PYRIMIDIN-5-YL)AMINO]METHYL]PIPERIDIN-3-OL COMPOUNDS AS CDK INHIBITORS
    Publication number: 20200345736
    Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 4-[[(7-aminopyrazolo[1,5-a]pyrimidin-5-yl)amino]methyl]piperidin-3-ol compounds (referred to herein as “APPAMP compounds”) that, inter alia, inhibit (e.g., selectively inhibit) CDK (e.g., CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8, CDK9, CDK10, CDK11, CDK12, CDK13, etc.).
    Type: Application
    Filed: September 20, 2018
    Publication date: November 5, 2020
    Inventors: Ash BAHL, Ed AINSCOW, Alexander BONDKE, Anthony G.M. BARRETT, Mihiro SUNOSE, Jason John SHIERS, Kamaldeep CHOHAN
  • Synthetic process for aminocyclohexyl ether compounds
    Patent number: 9586899
    Abstract: Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: March 7, 2017
    Assignee: Cardiome Pharma Corp.
    Inventors: Bertrand M. C. Plouvier, Doug Ta Hung Chou, Grace Jung, Lewis Siu Leung Choi, Tao Sheng, Anthony G. M. Barrett, Marco S. Passafaro, Martin Kurz, Daniel Moeckli, Pirmin Ulmann, Alfred Hedinger
  • PORPHYRAZINE OPTICAL AND DUAL OPTICAL/ MR CONTRAST AND THERAPEUTIC AGENTS
    Publication number: 20160031909
    Abstract: Porphyrazines capable of localizing in a tumor of a mammal are disclosed. The porphyrazines are used in methods of imaging a tumor and in methods of treating tumors, either alone or in combination with a chemotherapeutic agent and/or radiation.
    Type: Application
    Filed: March 6, 2014
    Publication date: February 4, 2016
    Inventors: Evan R. Trivedi, Emily A. Waters, Anthony G.M. Barrett, Brian M. Hoffman, Thomas J. Meade
  • SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS
    Publication number: 20150336887
    Abstract: Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed.
    Type: Application
    Filed: August 4, 2015
    Publication date: November 26, 2015
    Inventors: Bertrand M.C. Plouvier, Doug Ta Hung Chou, Grace Jung, Lewis Siu Leung Choi, Tao Sheng, Anthony G. M. Barrett, Marco S. Passafaro, Martin Kurz, Daniel Moeckli, Pirmin Ulmann, Alfred Hedinger
  • Synthetic process for aminocyclohexyl ether compounds
    Patent number: 9115081
    Abstract: Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: August 25, 2015
    Assignee: Cardiome Pharma Corp.
    Inventors: Bertrand M. C. Plouvier, Doug Ta Hung Chou, Grace Jung, Lewis Siu Leung Choi, Tao Sheng, Anthony G. M. Barrett, Marco S. Passafaro, Martin Kurz, Daniel Moeckli, Pirmin Ulmann, Alfred Hedinger
  • Synthetic process for aminocyclohexyl ether compounds
    Patent number: 8692002
    Abstract: Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed.
    Type: Grant
    Filed: November 18, 2005
    Date of Patent: April 8, 2014
    Assignee: Cardiome Pharma Corp.
    Inventors: Bertrand M. C. Plouvier, Doug Ta Hung Chou, Grace Jung, Lewis Siu Leung Choi, Tao Sheng, Anthony G. M. Barrett, Marco S. Passafaro, Martin Kurz, Daniel Moeckli, Pirmin Ulmann, Alfred Hedinger
  • Porphyrazine optical and dual optical/MR contrast and therapeutic agents
    Patent number: 8540967
    Abstract: Porphyrazines capable of localizing in a tumor of a mammal are disclosed. The porphyrazines are used in methods of imaging a tumor and in methods of treating tumors, either alone or in combination with a chemotherapeutic agent and/or radiation.
    Type: Grant
    Filed: September 4, 2009
    Date of Patent: September 24, 2013
    Assignee: Hoffman/Barrett, L.L.C.
    Inventors: Anthony G. M. Barrett, Evan R. Trivedi, Brian M. Hoffman
  • Process for preparing 5,7 diaminopyrazolo [1,5-A] pyrimidine compounds
    Patent number: 8507673
    Abstract: Processes for the preparation of certain 5,7-diaminopyrazolo[1,5-?]pyrimidine compounds comprising the reaction of a primary or secondary amine and a protected 5-halo-7-aminopyrazolo[1,5-?]pyrimidine compound in solvent system comprising water and one or more organic solvents, optionally in the presence of an exogenous base.
    Type: Grant
    Filed: June 9, 2011
    Date of Patent: August 13, 2013
    Assignees: Emory University, Imperial College of Science and Technology
    Inventors: Dennis C. Liotta, James P. Snyder, Ashutosh S. Jogalekar, Anthony G. M. Barrett, Matthew John Fuchter, Matthew J. Cook, Sebastian H. B. Kroll
  • SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS
    Publication number: 20130102791
    Abstract: Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed.
    Type: Application
    Filed: September 12, 2012
    Publication date: April 25, 2013
    Applicant: CARDIOME PHARMA CORP.
    Inventors: Bertrand M. C. Plouvier, Doug Ta Hung Chou, Grace Jung, Lewis Siu Leung Choi, Tao Sheng, Anthony G. M. Barrett, Marco S. Passafaro, Martin Kurz, Daniel Moeckli, Pirmin Ulmann, Alfred Hedinger
  • Aminocyclohexyl ether compounds and uses thereof
    Patent number: 8163938
    Abstract: Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: April 24, 2012
    Assignee: Cardiome Pharma Corp.
    Inventors: Grace Jung, Bertrand M. C. Plouvier, Yuzhong Liu, Jeff Jiqun Zhu, Tao Sheng, Anthony G. M. Barrett, Lewis Siu Leung Choi, Doug Ta Hung Chou
  • Process for Preparing 5,7 Diaminopyrazolo [1,5-a] Pyrimidine Compounds
    Publication number: 20120041198
    Abstract: Processes for the preparation of certain 5,7-diaminopyrazolo[1,5-?]pyrimidine compounds comprising the reaction of a primary or secondary amine and a protected 5-halo-7-aminopyrazolo[1,5-?]pyrimidine compound in solvent system comprising water and one or more organic solvents, optionally in the presence of an exogenous base.
    Type: Application
    Filed: June 9, 2011
    Publication date: February 16, 2012
    Inventors: Dennis C. Liotta, James P. Snyder, Ashutosh S. Jogalekar, Anthony G.M. Barrett, Matthew John Fuchter, Matthew J. Cook, Sebastian H.B. Kroll
  • Porphyrazine Optical and Dual Optical/MR Contrast and Therapeutic Agents
    Publication number: 20110293531
    Abstract: Porphyrazines capable of localizing in a tumor of a mammal are disclosed. The porphyrazines are used in methods of imaging a tumor and in methods of treating tumors, either alone or in combination with a chemotherapeutic agent and/or radiation.
    Type: Application
    Filed: September 4, 2009
    Publication date: December 1, 2011
    Applicant: Hoffman/Barrett, L.L.C.
    Inventors: Anthony G.M. Barrett, Evan R. Trivedi, Brian M. Hoffman
  • Selective inhibitors for cyclin-dependent kinases
    Patent number: 8067424
    Abstract: This invention provides a class of compounds which are useful for specifically inhibiting cyclin-dependent kinases. This class of compounds finds use in treating diseases resulting from inappropriate activity of cyclin-dependent kinases, including cancer, viral infections (e.g., HIV) neurodegenerative disorders (e.g. Alzheimer's disease), and cardiovascular disorders (e.g. atherosclerosis). Moreover, certain members of this class are particularly useful for inhibiting cyclin-dependent kinase 7 and are especially useful for the treatment of breast cancer.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: November 29, 2011
    Assignees: Emory University, Imperial College of Science and Technology
    Inventors: Ashutosh S. Jogalekar, James P. Snyder, Dennis C. Liotta, Anthony G. M. Barrett, Raoul Charles Dalmedo Stuart Coombes, Simak Ali, Aleksandra Siwicka, Jan Brackow, Bodo Scheiper
  • AMINOCYCLOHEXYL ETHER COMPOUNDS AND USES THEREOF
    Publication number: 20110004006
    Abstract: Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.
    Type: Application
    Filed: July 9, 2010
    Publication date: January 6, 2011
    Applicant: CARDIOME PHARMA CORP.
    Inventors: Grace Jung, Bertrand M. C. Plouvier, Yuzhong Liu, Jeff Jiqun Zhu, Tao Sheng, Anthony G. M. Barrett, Lewis Siu Leung Choi, Doug Ta Hung Chou
  • Selective Inhibitors for Cyclin-Dependent Kinases
    Publication number: 20100261683
    Abstract: This invention provides a class of compounds which are useful for specifically inhibiting cyclin-dependent kinases. This class of compounds finds use in treating diseases resulting from inappropriate activity of cyclin-dependent kinases, including cancer, viral infections (e.g., HIV) neurodegenerative disorders (e.g. Alzheimer's disease), and cardiovascular disorders (e.g. atherosclerosis). Moreover, certain members of this class are particularly useful for inhibiting cyclin-dependent kinase 7 and are especially useful for the treatment of breast cancer.
    Type: Application
    Filed: December 4, 2009
    Publication date: October 14, 2010
    Inventors: Ashutosh S. Jogalekar, James P. Snyder, Dennis C. Liotta, Anthony G.M. Barrett, RCDS Coombes, Simak Ali, Aleksandra Siwicka, Jan Brackow, Bodo Scheiper
  • Aminocyclohexyl ether compounds and uses thereof
    Patent number: 7767830
    Abstract: Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.
    Type: Grant
    Filed: March 23, 2007
    Date of Patent: August 3, 2010
    Assignee: Cardiome Pharma Corp.
    Inventors: Grace Jung, Bertrand M. C. Plouvier, Yuzhong Liu, Jeff Jiqun Zhu, Tao Sheng, Anthony G. M. Barrett, Lewis Siu Leung Choi, Doug Ta Hung Chou
  • SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS
    Publication number: 20100152464
    Abstract: Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed.
    Type: Application
    Filed: November 18, 2005
    Publication date: June 17, 2010
    Applicant: CARDIOME PHARMA CORP.
    Inventors: Bertrand M. C. Plouvier, Doug Ta Hung Chou, Grace Jung, Lewis Siu Leung Choi, Tao Sheng, Anthony G. M. Barrett, Marco S. Passafaro, Martin Kurz, Daniel Moeckli, Pirmin Ulmann, Alfred Hedinger
  • Compounds and method for preparing 3-methylcephams
    Patent number: 6908996
    Abstract: The present invention relates to novel intermediates for the preparation of 3-methylenecephams of the formula IIA. wherein: R is a carboxylic acid protecting group; R1 is a group of the formula; R10 is C1-C6 alkyl, C1-C6 polyfluoroalkyl, C3-C6 cycloalkyl, adamantyl, phenyl, substituted phenyl, phenyl(C1-C3 alkyl), diphenylmethyl, or substituted phenyl(C1-C3 alkyl), or a group of the formula Z is solid polymer support; and Z1 is one or two groups independently selected from the group consisting of hydrogen, halo, hydroxy, protected hydroxy, nitro, cyano, trifluoromethyl, C1-C4 alkyl, and C1-C4 alkoxy.
    Type: Grant
    Filed: November 12, 2003
    Date of Patent: June 21, 2005
    Assignee: Imperial College of London
    Inventors: Robin D. G. Cooper, Anthony G. M. Barrett
  • Novel compounds and method for preparing 3-methylcephams
    Publication number: 20040106790
    Abstract: The present invention relates to novel intermediates for the preparation of 3-methylenecephams. More specifically, the present invention relates to the intramolecular cyclization of penicillin sulfoxide derived monocyclic azetidinone as precursors to cephalosporin antibiotics.
    Type: Application
    Filed: November 12, 2003
    Publication date: June 3, 2004
    Inventors: Robin D.G. Cooper, Anthony G.M. Barrett