Patents by Inventor Anthony Holder

Anthony Holder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Screening method for substance binding to merozoite surface protein-1/42
    Publication number: 20070003987
    Abstract: Disclosed is a method of screening a test substance for possession of binding activity for possession of binding activity for MSP42 or a fragment thereof, the method comprising the steps of: combining or contacting, in any order, (i) a molecule comprising MSP142 or a fragment thereof, (ii) the test substance, and (iii) a comparison substance known to have binding activity for MSP142 or a fragment thereof; and determining the presence and/or amount, if any, of comparison substance and/or test substance bound of the MSP142 or fragment thereof.
    Type: Application
    Filed: June 18, 2004
    Publication date: January 4, 2007
    Applicants: MEDICAL RESEARCH COUNCIL, KING'S COLLEGE LONDON
    Inventors: Anton Dluzewski, Anthony Holder, Berry Birdsall, Jeff Babon, Stephen Martin, William Morgan, James Feeney, Michael Blackman, Suzanne Fleck, Barbara Saxty
  • Malaria vaccine
    Patent number: 7078043
    Abstract: A non-naturally occurring variant of a C-terminal fragment of a Plasmodium merozoite surface protein-1 (MSP-1) wherein said variant has (i) a reduced affinity, compared with a naturally occurring Plasmodium MSP-119, for at least one first antibody capable of blocking the binding of a second antibody, which second antibody inhibits the proteolytic cleavage of Plasmodium MSP-142 and (ii) substantially the same affinity for at least one third antibody compared with said naturally occurring Plasmodium MSP-119. which third antibody inhibits the proteolytic cleavage of Plasmodium MSP-142 is provided for use in an anti-malarial vaccine.
    Type: Grant
    Filed: October 16, 2001
    Date of Patent: July 18, 2006
    Assignee: Medical Research Council
    Inventors: Anthony Holder, Berry Birdsall, James Feeney, William Morgan, Shabih Syed, Chairat Uthaipibull
  • Malaria vaccine
    Publication number: 20020160017
    Abstract: A non-naturally occurring variant of a C-terminal fragment of a Plasmodium merozoite surface protein-1 (MSP-1) wherein said variant has (i) a reduced affinity, compared with a naturally occurring Plasmodium MSP-119, for at least one first antibody capable of blocking the binding of a second antibody, which second antibody inhibits the proteolytic cleavage of Plasmodium MSP-142 and (ii) substantially the same affinity for at least one third antibody compared with said naturally occurring Plasmodium MSP-119. which third antibody inhibits the proteolytic cleavage of Plasmodium MSP-142 is provided for use in an anti-malarial vaccine.
    Type: Application
    Filed: October 16, 2001
    Publication date: October 31, 2002
    Inventors: Anthony Holder, Berry Birdsall, James Feeney, William Morgan, Shabih Syed, Chairat Uthaipibull