Abstract: The invention relates to a compound of formula (1); wherein: R1 and R2 each independently represent a C1-6alkyl, C3-6 alkenyl, C3-6 cycloalkyl C1-3 alkyl or C3-6 cycloalkyl; each of which may be optionally substituted by 1 to 3 halogen atoms; R3 is isoxyzolidin-2-ylcarbonyl or tetrahydroisoxazin-2-ylcarbonyl wherein each ring is optionally substituted by one hydroxy group; Q is CO— or C(R4)(R5)-(wherein R4 is a hydrogen atom or C1-4alkyl and R5 is a hydrogen atom or hydroxy group); Ar is a 5- to 10-membered aromatic ring system wherein up to 4 ring atoms may be heteroatoms independently selected from nitrogen, oxygen and sulphur, the ring system being optionally substituted by one or more substituents as defined in the specification.

Abstract: The invention relates to a compound of formula (1)(A chemical formula should be inserted here—please see paper copy enclosed) wherein Q is —CO— or —C(R4)(R5)— (wherein R4 is a hydrogen atom or C1-4alkyl and R5 is a hydrogen atom or hydroxy group) and Ar is a 5- to 10-membered aromatic ring system wherein up to 4 ring atoms may be heteroatoms independently selected from nitrogen, oxygen and sulphur, the ring system being optionally substituted by one or more substituents as defined in the specification. It also relates to methods of preparing, pharmaceutical compositions containing and methods of using the compound of the formula (1), particularly in the modulation of autoimmune disease.

Abstract: There is described a sensor comprising an excitation winding, a signal generator operable to generate an excitation signal and arranged to apply the generated excitation signal to the excitation winding, a sensor winding electromagnetically coupled to the excitation winding and a signal processor operable to process a periodic electric signal generated in the sensor winding when the excitation signal is applied to the excitation winding by the signal generator to determine a value of a sensed parameter. The excitation signal comprises a periodic carrier signal having a first frequency modulated by a periodic modulation signal having a second frequency, the first frequency being greater than the second frequency. In this way, the sensor is well suited to using digital processing techniques both to generate the excitation signal and to process the signal induced in the sensor windings. In an embodiment, the sensor is used to detect the relative position of two members.

Abstract: There is described an inductive position sensor in which a signal generator applies a excitation signal to an excitation winding formed on a first member, the excitation winding being electromagnetically coupled to at least two resonant circuits formed on a second member which are spaced from each other along a measurement path. The excitation windings are shaped so that the electromagnetic coupling between the exciting winding and each of the resonators varies along the measurement path. In this way, by applying an excitation signal to the excitation winding, respective different signals are induced in the resonators which depend upon the relative position of the first and second members.

Abstract: There is described a sensor comprising an excitation winding, a signal generator operable to generate an excitation signal and arranged to apply the generated excitation signal to the excitation winding, a sensor winding electromagnetically coupled to the excitation winding and a signal processor operable to process a periodic electric signal generated in the sensor winding when the excitation signal is applied to the excitation winding by the signal generator to determine a value of a sensed parameter. The excitation signal comprises a periodic carrier signal having a first frequency modulated by a periodic modulation signal having a second frequency, the first frequency being greater than the second frequency. In this way, the sensor is well suited to using digital processing techniques both to generate the excitation signal and to process the signal induced in the sensor windings. In an embodiment, the sensor is used to detect the relative position of two members.

Abstract: The invention relates to thienopyridazinones of formula (I): wherein: R1 is C1-6 alkyl, C2-6 alkenyl or C3-6 cycloalkyl which is optionally substituted by C1-6 alkyl, each of the above being optionally substituted by one or more halogen atoms; R2 is C1-6 alkyl; R3 is a group CO—G or SO2—G where G is a 5- or 6-membered ring containing a nitrogen atom and a second heteroatom selected from oxygen and sulphur adjacent to the nitrogen, and optionally substituted by up to 3 groups selected from hydroxyl and C1-4 alkyl; Q is CR5R6 where R5 and R6 are as defined in the specification; and R4 is a 5- to 10-membered mono- or bi-cyclic aromatic ring system, containing 0 to 4 heteroatoms independently selected from nitrogen, oxygen and sulphur, the ring system being optionally substituted as described in the specification, and pharmaceutically acceptable salts and solvates thereof.

Abstract: A compound of formula or a pharmaceutically acceptable salt thereof, wherein R is —C(O)Ar1, —C(R4)(R5)Ar1 or Ar3; R3 represents a group X—R10 or Ar2; X represents a bond or a group NR11; and R10 represents C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, each of which may be optionally substituted by one or more substituents independently selected from carboxyl, hydroxyl, —C(O)—R12, C3-6 cycloalkyl, morpholinyl, —NR13R14, —SR15, —OR16, phenyl and halophenyl, or R10 represents a C3-6 cycloalkylcarbonyl, —C(O)CH2CN, halophenylcarbonyl or trifluoromethylcarbonyl group. The compounds or compositions thereof are useful in the treatment or prophylaxis of autoimmune, inflammatory, proliferative and hyperproliferative diseases.

Abstract: The invention relates to a compound of formula (1); wherein: R1 and R2 each independently represent a C1-6alkyl, C3-6 alkenyl, C3-6 cycloalkyl C1-3 alkyl or C3-6 cycloalkyl; each of which may be optionally substituted by 1 to 3 halogen atoms; R3 is isoxyzolidin-2-ylcarbonyl or tetrahydroisoxazin-2-ylcarbonyl wherein each ring is optionally substituted by one hydroxy group; Q is CO— or C(R4)(R5)—(wherein R4 is a hydrogen atom or C1-4alkyl and R5 is a hydrogen atom or hydroxy group); Ar is a 5- to 10-membered aromatic ring system wherein up to 4 ring atoms may be heteroatoms independently selected from nitrogen, oxygen and sulphur, the ring system being optionally substituted by one or more substituents as defined in the specification. It also relates to methods of preparing, pharmaceutical compositions containing and methods of using the compound of the formula (1), particularly in the modulation of autoimmune disease.

Abstract: The invention relates to a compound of formula (1)(A chemical formula should be inserted here—please see paper copy enclosed) wherein Q is —CO— or —C(R4)(R5)— (wherein R4 is a hydrogen atom or C1-4alkyl and R5 is a hydrogen atom or hydroxy group) and Ar is a 5- to 10-membered aromatic ring system wherein up to 4 ring atoms may be heteroatoms independently selected from nitrogen, oxygen and sulphur, the ring system being optionally substituted by one or more substituents as defined in the specification. It also relates to methods of preparing, pharmaceutical compositions containing and methods of using the compound of the formula (1), particularly in the modulation of autoimmune disease.

Abstract: The invention provides thieno[2,3-d]pyrimidinediones of general formula 1

Abstract: The present invention provides a solution for efficiently tracking web user sessions. Specifically, under the present invention, web user sessions are tracked on an analytics system based upon a unique identifier assigned to a requested web page and a session cookie that identifies a particular web user session. By tracking web user sessions in this manner, web page data transmitted during a particular web user session can be efficiently and accurately correlated for analysis.

Abstract: The present invention allows a web form submitted by a web user to be routed to an analysis system in real-time. Specifically, once a requested web page has been fully loaded and parsed, any existing submit methods and/or on-submit handlers attached to web forms within the web page are replaced with a new submit method and on-submit handler. When a valid web form is submitted by the user, the destination of the web form is changed to the analysis system, by the new submit method, for a fixed period of time. After the period of time has expired, the original destination is reinstated and the web form is routed thereto.

Abstract: Hair treatment compositions comprising a surfactant, a dispersed insoluble benefit agent, and PTFE microparticles. The use of PTFE microparticles as a deposition aid for a dispersed insoluble benefit agent in an aqueous hair treatment composition is also described.

Abstract: A method of data processing in which a composite data processing operation, for execution by a data processing device having a memory, is assembled by a user as a linked list of sub-operations selected from a set of possible data processing sub-operations, comprises the steps of: as a sub-operation is selected by the user for inclusion in the composite operation, loading into the memory sub-operation data defining parameters of that sub-operation including input and output interfaces of that sub-operation; and in response to an initiation of execution of a sub-operation, loading sub-operation program code into the memory for execution by the data processing device; in which the sub-operation data requires less memory space than the sub-operation program code.

Abstract: Video processing apparatus in which input images of an input video sequence are processed according to user adjustable video effects parameters to generate output images of an output video sequence comprises: rendering means for rendering images of the output video sequence according to a priority order of: (i) an image or images currently displayed for view by a user; (ii) first and last images of the output video sequence; and (iii) remaining images of the output video sequence.

Abstract: Hair treatment compositions comprising a surfactant, a dispersed insoluble benefit agent, and PTFE microparticles. The use of PTFE microparticles as a deposition aid for a dispersed insoluble benefit agent in an aqueous hair treatment composition is also described.

Abstract: The invention relates to triazolo[4,5-d]pyrimidin-3-yl derivatives which are useful in the treatment of platelet aggregation disorders.

Abstract: A convergent spray gun which combines a liquid resin and dry metallic powder externally of the nozzle of the spray gun that utilizes a pair of diametrically opposing passages disposed at 0.degree. and 90.degree. relative to the central resin discharging orifice where the central orifice is approximately 0.015 inch and the air for atomizing the fluids is approximately 0.187 inch and the atomizing angle is approximately 180.degree.. The metallic filler is added to the plume of the convergent spray at the low pressure section and the ratio of the fluids are controlled by a computerized system. The spray gun, controls and mixing chambers of the resin (two part) and powder fillers are housed in separate rooms and the dust where the powder fillers are metered is controlled.