Abstract: The present invention relates to a method of treating ileus in a patient, which includes administering a pharmaceutical composition that includes carbon monoxide to the patient.

Abstract: The invention provides a method for suppressing postoperative ileus in connection with the performance of a surgical procedure on a patient. In accordance with the inventive method, interleukin-10 (IL-10), glycine, a COX-2 inhibitor and a mast cell stabilizer are administered to the patient undergoing the surgical procedure in an amount and at a location sufficient to therapeutically or prophylactically suppress postoperative ileus in the patient. The invention further provides a pharmaceutically acceptable composition comprising interleukin-10 (IL-10), glycine, a COX-2 inhibitor, a mast cell stabilizer and a pharmaceutically-acceptable carrier.

Abstract: Proteins useful in the diagnosis of proliferative disorders of the colon are present in nuclear matrix protein preparations and can be characterized by molecular weight, isoelectric point, and amino acid sequence. The proteins may be identified, for example, by 2D-gel electrophoresis or by specific binding partners, such as antibodies.

Abstract: Proteins useful in the diagnosis of proliferative disorders of the colon are present in nuclear matrix protein preparations and can be characterized by molecular weight, isoelectric point, and amino acid sequence. The proteins may be identified, for example, by 2D-gel electrophoresis or by specific binding partners, such as antibodies.

Abstract: Proteins useful in the diagnosis of proliferative disorders of the colon are present in nuclear matrix protein preparations and can be characterized by molecular weight, isoelectric point, and amino acid sequence. The proteins may be identified, for example, by 2D-gel electrophoresis or by specific binding partners, such as antibodies.

Abstract: A cast metal sideframe for use in a railway car truck has a spring seat for supporting the springs of a spring set. The sideframe is molded using a core that includes a portion for defining the exterior surface of the spring seat. The core can be a single piece or multi-piece core. The spring seat includes a plurality of aerodynamically-shaped spring retainers formed on the top face spring seat. The aerodynamic shape of the spring retainers reduces the tendency for sand to swirl and create voids during formation of the sand core that is used to mold the sideframe. The aerodynamic shape may include forming at least some of the side walls of the spring retainers at an obtuse angle with the top face of the spring seat. The spring retainers may have concave top faces so as to reduce the volume of material comprising the spring retainers.

Abstract: Proteins useful in the diagnosis of proliferative disorders of the colon are present in nuclear matrix protein preparations and can be characterized by molecular weight, isoelectric point, and amino acid sequence. The proteins may be identified, for example, by 2D-gel electrophoresis or by specific binding partners, such as antibodies.

Abstract: The number of cores used in casting bolsters and sideframes is reduced. End cores and a center core are placed in a mold with cope and drag portions. Each core includes integrally-formed portions for defining portions of the interior surfaces of the bolster or sideframes. The integrally-formed portions may include a portion for defining the side window of the sideframe formed integrally with other portions, and may include a pedestal portion formed integrally with other portions. The integrally-formed portions may contact both the cope and drag portions of the mold. The end cores may include integrally formed core prints for supporting the core in the mold. The integrally-formed portions of the center core include connections that are formed integrally with the other portions. Molten metal is introduced into the mold to cast the bolster or sideframe.

Abstract: The present invention relates to a method of treating ileus in a patient, which includes administering a pharmaceutical composition that includes carbon monoxide to the patient.

Abstract: A cast metal sideframe for use in a railway car truck has a spring seat for supporting the springs of a spring set. The sideframe is molded using a core that includes a portion for defining the exterior surface of the spring seat. The core can be a single piece or multi-piece core. The spring seat includes a plurality of aerodynamically-shaped spring retainers formed on the top face spring seat. The aerodynamic shape of the spring retainers reduces the tendency for sand to swirl and create voids during formation of the sand core that is used to mold the sideframe. The aerodynamic shape may include forming at least some of the side walls of the spring retainers at an obtuse angle with the top face of the spring seat. The spring retainers may have concave top faces so as to reduce the volume of material comprising the spring retainers.

Abstract: The number of cores used in casting sideframes is reduced. A pair of end cores and a center core are placed in a mold with cope and drag portions. Each core includes integrally-formed portions for defining portions of the interior surfaces of the sideframes. The integrally-formed portions may include a portion for defining the side window of the sideframe formed integrally with other portions, and may include a pedestal portion formed integrally with other portions. The integrally-formed portions may contact both the cope and drag portions of the mold. The end cores may include integrally formed core prints for supporting the core in the mold. The integrally-formed portions of the center core include connections that are formed integrally with the other portions. Molten metal is introduced into the mold to cast the sideframe.

Abstract: The number of cores used in casting bolsters and sideframes is reduced. End cores and a center core are placed in a mold with cope and drag portions. Each core includes integrally-formed portions for defining portions of the interior surfaces of the bolster or sideframes. The integrally-formed portions may include a portion for defining the side window of the sideframe formed integrally with other portions, and may include a pedestal portion formed integrally with other portions. The integrally-formed portions may contact both the cope and drag portions of the mold. The end cores may include integrally formed core prints for supporting the core in the mold. The integrally-formed portions of the center core include connections that are formed integrally with the other portions. Molten metal is introduced into the mold to cast the bolster or sideframe.

Abstract: An improvement in dead lever lugs for mounting on cast metal bolsters for railway trucks is disclosed. The bolster has two side walls. The side walls have angled portions that meet in radii along the junctures of the angled portions. The dead lever lug has two arms joined by a bridge section. Each of the arms has a mounting surface that is shaped to mate with the shape of one of the angled surfaces of the bolster. The mounting surfaces of the dead lever lug arms are separated by a gap. When the dead lever lug is mounted on the bolster, the dead lever lug straddles the juncture of the angled portions of the side wall. One mounting surface of each arm is positioned against one of the angled portions of the side wall and the gap overlies the juncture of the two angled portions of the side wall. With the dead lever lug of the present invention, no flat raised mounting area is needed on the side wall of the bolster.

Abstract: The number of cores used in casting sideframes is reduced. A pair of end cores and a center core are placed in a mold with cope and drag portions. Each core includes integrally-formed portions for defining portions of the interior surfaces of the sideframes. The integrally-formed portions may include a portion for defining the side window of the sideframe formed integrally with other portions, and may include a pedestal portion formed integrally with other portions. The integrally-formed portions may contact both the cope and drag portions of the mold. The end cores may include integrally formed core prints for supporting the core in the mold. The integrally-formed portions of the center core include connections that are formed integrally with the other portions. Molten metal is introduced into the mold to cast the sideframe.

Abstract: An improvement in cast metal bolsters for railway trucks is disclosed. The bolster has a top wall, a bottom wall and sidewalls. All of the walls have interior and exterior surfaces. Two transverse ribs extend between the top wall and bottom wall and two spaced longitudinal ribs extend from the top wall to the bottom wall. The bolster has a top portion, a bottom portion, a central vertical longitudinal plane between the sidewalls and a perpendicular vertical transverse plane. The transverse ribs have opposite faces in the top portion and in the bottom portion. A vertical plane extends between the opposite faces of the transverse ribs in the top portion and in the bottom portion. The opposite faces of the transverse ribs in the top portion do not diverge from a vertical plane in the same direction and opposite faces in the bottom portion that do not diverge from a vertical plane in the same direction. The transverse ribs may have a vertical plane of symmetry.

Abstract: Improvements in cast metal sideframes for railway trucks are disclosed, along with improvements in the processes of casting such products and the cores used in the casting process. A radial draft is provided on the casting surrounding a bolt hole at a core parting or joint line so that nuts and washers may be evenly loaded. The radial draft is formed on the sideframe column, on the side opposite the side to which a wear plate is mounted. The bolts for mounting the wear plate extend through the bolt hole, and the nuts and washers connected to the bolts bear against the tapered radial draft surface.

Abstract: Improvements in the method of making cast metal bolsters for railway trucks are disclosed. The bolster is cast in a mold using a one-piece center core. The center core has a first end inboard of the first outboard end of the mold and a second end inboard of the second outboard end of the mold. The one-piece center core extends from the first end across the center area of the mold to the second end. It has surfaces to define interior surfaces of the bolster top wall, bottom wall and side walls on both sides of the bolster central transverse plane and bolster central longitudinal plane. Two one-piece end cores are also used. Each one-piece end core has surfaces shaped to define the interior surfaces of the bolster top wall, bottom wall and side walls from a position inboard of one friction shoe pocket to the first outboard end of the bolster.

Abstract: Improvements in cast metal sideframes and bolsters for railway trucks are disclosed, along with improvements in the processes of casting such products and the cores used in the casting process. In one aspect, the cores are consolidated to provide two one-piece end cores, a one-piece center core, and a bottom center core for the sideframe and two one-piece end cores and a center core for the bolster. The consolidated cores may include cores to define various bolt holes. In another aspect, various cores may be made with step joints for interlocking support without weight-supporting chaplets. In another aspect, a locator boss may be formed on one or more of the cores for proper positioning of the core on the drag mold. Other improvements disclosed include providing a radial draft on the casting surrounding a bolt hole at a core parting or joint line so that nuts and washers may be evenly loaded. In the bolster interior, ribs may be straightened.