Patents by Inventor Anthony J. Cocuzza

Anthony J. Cocuzza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for synthesizing substituted isoquinolines
    Patent number: 8357806
    Abstract: The present disclosure generally relates to a process for synthesizing optionally substituted 1-chloro-4-methoxyisoquinolines. The present disclosure also relates to intermediates useful in this process.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: January 22, 2013
    Assignee: Bristol-Myers Squibb Company
    Inventors: Shawn A. Springfield, Wendel W. Doubleday, Frederic Buono, Michel A. Couturier, Yvonne Lear, Denis Favreau, Kathia Levesque, Percy Sarwood Manchand, Markus Frieser, Anthony J. Cocuzza
  • Process for Synthesizing Substituted Isoquinolines
    Publication number: 20120220774
    Abstract: The present disclosure generally relates to a process for synthesizing optionally substituted 1-chloro-4-methoxyisoquinolines. The present disclosure also relates to intermediates useful in this process.
    Type: Application
    Filed: May 10, 2012
    Publication date: August 30, 2012
    Inventors: Shawn A. Springfield, Wendel W. Doubleday, Frederic Buono, Michel A. Couturier, Yvonne Lear, Denis Favreau, Kathia Levesque, Percy Sarwood Manchand, Markus Frieser, Anthony J. Cocuzza
  • Process for Synthesizing Substituted Isoquinolines
    Publication number: 20100056792
    Abstract: The present disclosure generally relates to a process for synthesizing optionally substituted 1-chloro-4-methoxyisoquinolines. The present disclosure also relates to intermediates useful in this process.
    Type: Application
    Filed: August 25, 2009
    Publication date: March 4, 2010
    Inventors: Shawn A. Springfield, Wendel W. Doubleday, Frederic Buono, Michel A. Couturier, Yvonne Lear, Denis Favreau, Kathia Levesque, Percy Sarwood Manchand, Markus Frieser, Anthony J. Cocuzza, Hyungcheol Kim, Sangsoo Lee, Chunyoung Kim, Soonha Yang, Eunhee Choi
  • Tricyclic-2-pyridone compounds useful as HIV reverse transcriptase inhibitors
    Patent number: 6969721
    Abstract: The present invention relates to tricyclic 2-pyridone compounds of formula (I): or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.
    Type: Grant
    Filed: June 10, 2003
    Date of Patent: November 29, 2005
    Assignee: Bristol-Myers Squibb Pharma
    Inventors: James D. Rodgers, Haisheng Wang, Mona Patel, Argyrios Arvanitis, Anthony J. Cocuzza
  • Tricyclic-2-pyridone compounds useful as HIV reverse transcriptase inhibitors
    Publication number: 20040023955
    Abstract: The present invention relates to tricyclic 2-pyridone compounds of formula (I): 1
    Type: Application
    Filed: June 10, 2003
    Publication date: February 5, 2004
    Inventors: James D. Rodgers, Haisheng Wang, Mona Patel, Argyrios Arvanitis, Anthony J. Cocuzza
  • Tricyclic-2-pyridone compounds useful as HIV reverse transcriptase inhibitors
    Patent number: 6596729
    Abstract: The present invention relates to tricyclic 2-pyridone compounds of formula (I): or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: July 22, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: James D. Rodgers, Haisheng Wang, Mona Patel, Argyrios Arvanitis, Anthony J. Cocuzza
  • 5, 5-disubstituted-1, 5-dihydro-4, 1-benzoxazepin-2 (3H)-ones useful as HIV reverse transcriptase inhibitors
    Patent number: 6489320
    Abstract: The present invention relates to benzoxazepinones of formula I: or stereoisomeric forms or mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same and methods of using the same for treating viral infection or as an assay standard or reagent.
    Type: Grant
    Filed: September 7, 2000
    Date of Patent: December 3, 2002
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Anthony J. Cocuzza, James D. Rodgers
  • Tricyclic-2-pyridone compounds useful as HIV reverse transcriptase inhibitors
    Publication number: 20020107261
    Abstract: The present invention relates to tricyclic 2-pyridone compounds of formula (I): 1
    Type: Application
    Filed: July 19, 2001
    Publication date: August 8, 2002
    Inventors: James D. Rodgers, Haisheng Wang, Mona Patel, Argyrios Arvanitis, Anthony J. Cocuzza
  • 1,3-Benzodiazepin-2-ones and 1,3-Benzoxazepin-2-ones useful as HIV reverse transcriptase inhibitors
    Patent number: 6204262
    Abstract: The present invention relates to 1,3-benzodiazepin-2-ones and 1,3-benzoxazepin-2-ones of formula I: or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: March 20, 2001
    Assignee: DuPont Pharmaceuticals Company
    Inventors: James D. Rodgers, Anthony J. Cocuzza, Donna M. Bilder
  • 5,5-disubstituted-1,5-dihydro-4,1-benzoxazepin-2 (3H)-ones useful as HIV reverse transcriptase inhibitors
    Patent number: 6140320
    Abstract: The present invention relates to benzoxazepinones of formula I: ##STR1## or stereoisomeric forms or mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same and methods of using the same for treating viral infection or as an assay standard or reagent.
    Type: Grant
    Filed: September 1, 1998
    Date of Patent: October 31, 2000
    Assignee: Dupont Pharmaceuticals Company
    Inventors: Anthony J. Cocuzza, James D. Rodgers
  • Aryl- and arylamino- substituted heterocycles as corticotropin releasing hormone antagonists
    Patent number: 6103737
    Abstract: Corticotropin releasing factor (CRF) antagonists of formula I: ##STR1## and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress disorder, supranuclear palsy and feeding disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress in mammals.
    Type: Grant
    Filed: July 2, 1998
    Date of Patent: August 15, 2000
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Anthony J. Cocuzza, Frank W. Hobbs, James P. Beck, Paul J. Gilligan
  • Method for sequencing DNA using biotin-strepavidin conjugates to facilitate the purification of primer extension products
    Patent number: 5484701
    Abstract: A simplified method for isolating primer extension products and generating them in a form appropriate for electrophoresis is disclosed. The method is compatible with automated DNA sequencing procedures.
    Type: Grant
    Filed: January 31, 1992
    Date of Patent: January 16, 1996
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Anthony J. Cocuzza, Frank W. Hobbs, Jr., Robert J. Zagursky, Neil A. Straus
  • Alkynylamino-nucleotides
    Patent number: 5047519
    Abstract: Alkynylamino-nucleotides and labeled alkynylamino-nucleotides useful, for example, as chain terminating substrates for DNA sequencing are provided along with several key intermediates and processes for their preparation.
    Type: Grant
    Filed: June 12, 1987
    Date of Patent: September 10, 1991
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Frank W. Hobbs, Jr., Anthony J. Cocuzza
  • Reagents for the preparation of 5'-biotinylated oligonucleotides
    Patent number: 4908453
    Abstract: Reagents useful in the preparation of 5'-biotinylated oligonucleotides are disclosed.
    Type: Grant
    Filed: January 23, 1989
    Date of Patent: March 13, 1990
    Assignee: E. I. Du Pont De Nemours and Company
    Inventor: Anthony J. Cocuzza
  • Antihypertensive 1-[bis-(substituted phenyl)methyl]-4[2-(1,2,3,4-tetrahydro-substituted naphthalen-1-ylidene)ethyl]piperazines
    Patent number: 4590274
    Abstract: Antihypertensive piperazineethylidenebenzocycloalkanes are provided. These compounds have the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are independently C.sub.1 -C.sub.6 alkyl, hydrogen, C.sub.1 -C.sub.6 alkoxy, hydroxy, or halo, or R.sub.1 and R.sub.2 or R.sub.2 and R.sub.3 together can form a methylenedioxy bridge;R.sub.4 is H or C.sub.1 -C.sub.6 alkyl;n is 0, 1 or 2;m is 0, 1, 2 or 3; andAr.sub.1 and Ar.sub.2 are independently phenyl optionally substituted with one or two of halogen, hydroxy, or C.sub.1 -C.sub.6 alkoxy groups,or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 3, 1985
    Date of Patent: May 20, 1986
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Anthony J. Cocuzza
  • Cyclobutanone antibacterials
    Patent number: 4505905
    Abstract: Certain 7-oxobicyclo[3.2.0] hept-2-en-2-carboxylic acids, esters, and salts thereof useful as antibacterial agents or as intermediates for antibacterial agents, and methods for making and using them.
    Type: Grant
    Filed: April 15, 1982
    Date of Patent: March 19, 1985
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: George A. Boswell, Jr., Anthony J. Cocuzza