Abstract: A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes.

Abstract: A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes.

Abstract: Disclosed are methods for detecting resistance to immune checkpoint blockade inhibition in cancer patients expressing a epidermal growth factor receptor (EGFR) splice variant.

Abstract: The present invention relates to a clock recovery circuit for generation of a recovered clock signal from a received data stream using a weighted combination of phase component signals. The clock recovery circuit comprises: a detector to detect the phase of a received data stream; a selector comprising a differential generator arranged to generate at least two related signals in dependence on the detected phase; and a clock signal generator to receive the at least two related signals and select related proportions of two or more of a plurality of phase component signals for combination, thereby to generate a recovered clock signal.

Abstract: The invention is directed to parapoxvirus vectors. Specifically provided are orf virus vectors containing exogenous DNA. The exogenous DNA may encode a heterologous peptide or polypeptide of which expression is desired, or may encode an antigen capable of inducing an immune response. The capacity to express antigens make these vectors suitable for use in vaccines.

Abstract: In an analogue indicating device (e.g. a clock) in which the relative positions of two relatively movable components (FIGS. 1-3; 26/28 and 12) is judged by the position of a reference marker (30/32) on one of the components (26/28) in relation to an adjacent scale (48) on the other component (12), the scale is constituted by a hologram (in 12) which when illuminated by a predetermined reference light (33) portrays a desired image of the scale (48) against which the reference marker (26/28) is seen. That image may also portray an environment (34) (e.g. a clock case) in which the scale (48) appears to be contained. The reference marker (26/28) may also be constituted by a hologram for portraying a holographic image of the reference marker. Alternatively, a holographically portrayed reference marker may cooperate with a real scale. The holographically produced image is preferably coplanar with the other image, whether the latter image be real or holographically produced, so as to elliminate parallax errors.

Abstract: A holographic display apparatus, for displaying an image embodied in a hologram, has a hologram support for receiving and supporting a hologram in a viewing position, a reference light source disposed adjacent a boundary of the hologram support in a predetermined baffled position such that light emanating from the source cannot fall directly onto a hologram supported on the support, and at least one light reflecting surface disposed adjacent that boundary of the support and arranged to direct light from the source onto a hologram supported on the support so as to be incident on the hologram at a predetermined acute reference angle, which angle corresponds substantially to the angle of incidence relative to the hologram of a predetermined reference light used in producing that hologram. The at least one reflecting surface may be planar, or curved in one or more directions. Holograms in a variety of different forms may be illuminated.

Abstract: A creel is provided for a textile machine, the creel including a frame mounted in a C-shaped support structure so as to be pivotal about its vertical central axis. The frame defines four spaces on each of three levels. In each space are pivotally mounted a pair of mutually spaced package support arms which are movable between two operative positions offset towards each side of the space so that a larger diameter reserve package can only be accomodated on one package arm when the in-use package on the other package arm of that pair has been used sufficiently to reduce its diameter significantly. This enables large packages to be used in a creel of lower height than would otherwise be required, to reduce package handling problems.

Abstract: A package mounting arrangement in a textile machine comprises a cradle having a U-shaped form with cradle arms extending from a spine. The cradle arms extend rearwardly of the machine from a pivot axis passing through the arms midway between the spine and package mounting means at the free ends of the arms and disposed at that side of the nip between the package and package driving bowl from which the yarn is fed to the nip in a direction rearwardly of the machine from a traverse mechanism located at the front of the machine. The arrangement provides stability of running, easy access to the package which is presented at the front of the machine for doffing, easy threading of the yarn and easy access to the traverse mechanism for maintainance. The spine forms a handle, a package mass compensating weight, traverse mechanism protection and a support for the operators hand during package doffing.

Abstract: A machine and method for collecting gall from animal bladders is provided. The machine includes contra-rotating rollers which cut and squeeze gall bladders fed onto the rollers. A perforated drum receives the gall and cut bladders issuing from the rollers and separates the gall from the cut bladders. A high yield of gall is attained.