Abstract: Spray-dried metal-organic frameworks (MOFs) comprising therapeutic and/or diagnostic metal ions and therapeutic and/or diagnostic organic ligands are described. Both the metal ion and organic ligand can have activity related to the treatment and/or diagnosis of a pulmonary disease or disorder, such as tuberculosis, or another disease related to a pulmonary infection. The MOFs can be adminstered to subjects via inhalation (e.g., as aerosols). Methods of treating and diagnosing pulmonary diseases or disorders are also described.

Abstract: A facemask includes a facemask body, a plurality of electrical contacts and a control circuit. The facemask body has an end including an opening and a skin contact perimeter extending along a periphery of the opening, with the skin contact perimeter configured to sealingly engage with a user's face. Each electrical contact is disposed at a respective region of the skin contact perimeter, and each electrical contact is configured to sense when the respective region of the skin contact perimeter is sealingly engaged with a user's face. The control circuit is disposed on the facemask body, and the control circuit is configured to receive a signal from each electrical contact when the respective region of the skin contact perimeter is sealingly engaged with a user's face and to initiate output of an audible stimulus and/or a visual stimulus in response to receiving a concurrent signal from all of the plurality of electrical contacts.

Abstract: Capreomycin sulfate and CPZEN-45, which act in non-identical manners to treat tuberculosis infection, are combined into particles by spray drying thereby giving an intimate mixture for combination drug therapy. The spray dried combination powder is prepared in an aerodynamic particle size range (such as 1-5 ?m) suitable for pulmonary delivery when delivered from an inhaler.

Abstract: A facemask includes a facemask body, a plurality of electrical contacts and a control circuit. The facemask body has an end including an opening and a skin contact perimeter extending along a periphery of the opening, with the skin contact perimeter configured to sealingly engage with a user's face. Each electrical contact is disposed at a respective region of the skin contact perimeter, and each electrical contact is configured to sense when the respective region of the skin contact perimeter is sealingly engaged with a user's face. The control circuit is disposed on the facemask body, and the control circuit is configured to receive a signal from each electrical contact when the respective region of the skin contact perimeter is sealingly engaged with a user's face and to initiate output of an audible stimulus and/or a visual stimulus in response to receiving a concurrent signal from all of the plurality of electrical contacts.

Abstract: A facemask includes a facemask body, a plurality of electrical contacts and a control circuit. The facemask body has an end including an opening and a skin contact perimeter extending along a periphery of the opening, with the skin contact perimeter configured to sealingly engage with a user's face. Each electrical contact is disposed at a respective region of the skin contact perimeter, and each electrical contact is configured to sense when the respective region of the skin contact perimeter is sealingly engaged with a user's face. The control circuit is disposed on the facemask body, and the control circuit is configured to receive a signal from each electrical contact when the respective region of the skin contact perimeter is sealingly engaged with a user's face and to initiate output of an audible stimulus and/or a visual stimulus in response to receiving a concurrent signal from all of the plurality of electrical contacts.

Abstract: Dosing heads for apparatus for dispensing a defined amount of dry powder concurrently to a plurality of spaced apart dose receiving containers include a plurality of spaced apart elongate channels having a channel length with an upper end defining an entry orifice and a lower end defining an exit port. In use, the dosing heads are aligned with a dry powder bed residing above and in communication with the dosing head and at least one vibration source in communication with the dosing head channels configured to controllably apply a vibration flow signal. When the vibration flow signal is applied to the dosing head channels, dry powder from the dry powder bed flows through the elongate channels and out the exit port and when the flow signal is removed, dry powder does not flow through the dosing head elongate channels.

Abstract: Dosing heads for apparatus for dispensing a defined amount of dry powder concurrently to a plurality of spaced apart dose receiving containers include a plurality of spaced apart elongate channels having a channel length with an upper end defining an entry orifice and a lower end defining an exit port. In use, the dosing heads are aligned with a dry powder bed residing above and in communication with the dosing head and at least one vibration source in communication with the dosing head channels configured to controllably apply a vibration flow signal. When the vibration flow signal is applied to the dosing head channels, dry powder from the dry powder bed flows through the elongate channels and out the exit port and when the flow signal is removed, dry powder does not flow through the dosing head elongate channels.

Abstract: A facemask includes a facemask body, a plurality of electrical contacts and a control circuit. The facemask body has an end including an opening and a skin contact perimeter extending along a periphery of the opening, with the skin contact perimeter configured to sealingly engage with a user's face. Each electrical contact is disposed at a respective region of the skin contact perimeter, and each electrical contact is configured to sense when the respective region of the skin contact perimeter is sealingly engaged with a user's face. The control circuit is disposed on the facemask body, and the control circuit is configured to receive a signal from each electrical contact when the respective region of the skin contact perimeter is sealingly engaged with a user's face and to initiate output of an audible stimulus and/or a visual stimulus in response to receiving a concurrent signal from all of the plurality of electrical contacts.

Abstract: Apparatus for dispensing a defined amount of dry powder concurrently to a plurality of spaced apart dose receiving containers include: (a) a dosing head comprising a support body with a plurality of spaced apart elongate channels having a channel length with an upper end defining an entry orifice and a lower end defining an exit port; (b) a dry powder bed residing above and in communication with the dosing head; and (c) at least one vibration source in communication with the dosing head channels configured to controllably apply a vibration flow signal, wherein, when the vibration flow signal is applied to the dosing head channels, dry powder from the dry powder bed flows through the elongate channels and out the exit port and when the flow signal is removed, dry powder does not flow through the dosing head elongate channels.

Abstract: Apparatus for dispensing a defined amount of dry powder concurrently to a plurality of spaced apart dose receiving containers include: (a) a dosing head comprising a support body with a plurality of spaced apart elongate channels having a channel length with an upper end defining an entry orifice and a lower end defining an exit port; (b) a dry powder bed residing above and in communication with the dosing head; and (c) at least one vibration source in communication with the dosing head channels configured to controllably apply a vibration flow signal, wherein, when the vibration flow signal is applied to the dosing head channels, dry powder from the dry powder bed flows through the elongate channels and out the exit port and when the flow signal is removed, dry powder does not flow through the dosing head elongate channels.

Abstract: Apparatus for dispensing a defined amount of dry powder concurrently to a plurality of spaced apart dose receiving containers include: (a) a dosing head comprising a support body with a plurality of spaced apart elongate channels having a channel length with an upper end defining an entry orifice and a lower end defining an exit port; (b) a dry powder bed residing above and in communication with the dosing head; and (c) at least one vibration source in communication with the dosing head channels configured to controllably apply a vibration flow signal, wherein, when the vibration flow signal is applied to the dosing head channels, dry powder from the dry powder bed flows through the elongate channels and out the exit port and when the flow signal is removed, dry powder does not flow through the dosing head elongate channels.

Abstract: Apparatus for dispensing a defined amount of dry powder concurrently to a plurality of spaced apart dose receiving containers include: (a) a dosing head comprising a support body with a plurality of spaced apart elongate channels having a channel length with an upper end defining an entry orifice and a lower end defining an exit port; (b) a dry powder bed residing above and in communication with the dosing head; and (c) at least one vibration source in communication with the dosing head channels configured to controllably apply a vibration flow signal, wherein, when the vibration flow signal is applied to the dosing head channels, dry powder from the dry powder bed flows through the elongate channels and out the exit port and when the flow signal is removed, dry powder does not flow through the dosing head elongate channels.

Abstract: Dry powder inhalers with a multi-dose dry powder package for dispensing pharmaceutical grade formulations of inhalable dry powder, include: (a) a blister package comprising a plurality of spaced apart sealed blisters thereon, each blister having a projecting ceiling and a floor defining a blister channel therebetween, the blister channel comprising a dry powder therein; (b) a movable blade cartridge holding a blade at a forward portion thereof; and (c) an extendable mouthpiece attached to the movable blade cartridge. In operation, a user pulls the mouthpiece outward and then pushes the mouthpiece inward to cause the blister package to advance to position a blister in a selected dispensing position in the inhaler and to cause the blade cartridge to move the blade across a blister ceiling held in the dispensing position in the inhaler to thereby open the blister held in the dispensing position.

Abstract: Dry powder blister packages include sealed blisters with a piezoelectric active layer that flexes to vibrate the dry powder in a blister to facilitate active dispersion.

Abstract: Dry powder blister packages include sealed blisters with a piezoelectric active layer that flexes to vibrate the dry powder in a blister to facilitate active dispersion.

Abstract: Dry powder inhalers with a multi-dose dry powder package for dispensing pharmaceutical grade formulations of inhalable dry powder, include: (a) a blister package comprising a plurality of spaced apart sealed blisters thereon, each blister having a projecting ceiling and a floor defining a blister channel therebetween, the blister channel comprising a dry powder therein; (b) a movable blade cartridge holding a blade at a forward portion thereof; and (c) an extendable mouthpiece attached to the movable blade cartridge. In operation, a user pulls the mouthpiece outward and then pushes the mouthpiece inward to cause the blister package to advance to position a blister in a selected dispensing position in the inhaler and to cause the blade cartridge to move the blade across a blister ceiling held in the dispensing position in the inhaler to thereby open the blister held in the dispensing position.