Abstract: A method for hyperpolarizing nuclei contained in an MR (=magnetic resonance) agent using Brute Force, has the steps of a) providing a sample (1), including the MR agent, optionally dissolved in a solvent, and a relaxation agent (2); and b) exposing the sample (1) to a magnetic field B0, with B0?0.5 T, and a cryogenic temperature Tcr, with Tcr?5K. The method is characterized in that the relaxation agent (2) is a particulate relaxation agent (2) having particles of a grain size of 20 ?m or less, with a volume content of these particles of at least 1% within the sample. An improved Brute Force hyperpolarization method is thereby provided, which is broadly applicable and simple to perform.

Abstract: A method for hyperpolarizing nuclei contained in an MR (=magnetic resonance) agent using Brute Force, has the steps of a) providing a sample (1), including the MR agent, optionally dissolved in a solvent, and a relaxation agent (2); and b) exposing the sample (1) to a magnetic field B0, with B0?0.5T, and a cryogenic temperature Tcr, with Tcr?5K. The method is characterized in that the relaxation agent (2) is a particulate relaxation agent (2) having particles of a grain size of 20 ?m or less, with a volume content of these particles of at least 1% within the sample. An improved Brute Force hyperpolarization method is thereby provided, which is broadly applicable and simple to perform.