Patents by Inventor Anthony Joseph Varano, JR.

Anthony Joseph Varano, JR. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted isoquinolines as rock kinase inhibitors
    Patent number: 11912719
    Abstract: The present invention relates to indoline-based compounds that inhibit Rho-associated protein kinase (ROCK) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.
    Type: Grant
    Filed: December 29, 2021
    Date of Patent: February 27, 2024
    Assignee: Cervello Therapeutics, LLC.
    Inventors: Matthew Randolph Lee, Anthony Joseph Varano, Jr., Thomas P. Bobinski
  • SUBSTITUTED ISOQUINOLINES AS ROCK KINASE INHIBITORS
    Publication number: 20220119406
    Abstract: The present invention relates to indoline-based compounds that inhibit Rho-associated protein kinase (ROCK) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.
    Type: Application
    Filed: December 29, 2021
    Publication date: April 21, 2022
    Inventors: Matthew Randolph Lee, Anthony Joseph Varano, JR., Thomas P. Bobinski
  • Substituted isoquinolines as rock kinase inhibitors
    Patent number: 11248004
    Abstract: The present invention relates to indoline-based compounds that inhibit Rho-associated protein kinase (ROCK) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.
    Type: Grant
    Filed: May 5, 2020
    Date of Patent: February 15, 2022
    Assignee: Cervello Therapeutics, LLC.
    Inventors: Matthew Randolph Lee, Anthony Joseph Varano, Jr., Thomas P. Bobinski
  • ROCK KINASE INHIBITORS
    Publication number: 20200262844
    Abstract: The present invention relates to compounds that inhibit ROCK activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.
    Type: Application
    Filed: May 5, 2020
    Publication date: August 20, 2020
    Inventors: Matthew Randolph Lee, Anthony Joseph Varano, JR., Thomas P. Bobinski
  • Substituted isoquinolines and phthalazines as rock kinase inhibitors
    Patent number: 10745381
    Abstract: The present invention relates to indoline-based compounds that inhibit Rho-associated protein kinase (ROCK) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: August 18, 2020
    Assignee: Cervello Therapeutics, LLC.
    Inventors: Matthew Randolph Lee, Anthony Joseph Varano, Jr.
  • ROCK KINASE INHIBITORS
    Publication number: 20200140412
    Abstract: The present invention relates to compounds that inhibit ROCK activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.
    Type: Application
    Filed: November 6, 2019
    Publication date: May 7, 2020
    Inventors: Matthew Randolph Lee, Anthony Joseph Varano, JR.