Abstract: Ambulatory patient wearable vital sign monitoring system, often comprising a plurality of ambulatory patient wearable ECG sensors, pulse oximeters, and oscillometric blood pressure monitors, configured to transmit sensor data to a wearable computerized device such as a smartphone. The smartphone will typically be configured to obtain the patient's health history and other health status information, often by querying the patient. The device will use this health history and health status information to select vital sign operating times and sensor data acquisition parameters. The system may also use the history, health status information and the sensor data to return diagnostic information pertaining to the patient's history the patient and optionally other devices or caregivers. In some embodiments, the system may also report on medication adherence as well. Examples of multi-sensor neck worn devices, three-sensor hand carried devices, and purely ear worn devices (e.g. for sleep apnea) are presented.