Abstract: It was discovered that hydrogel scaffolds can be used to induce phase separation as aqueous two-phase systems (ATPSs) pass through and/or rehydrate the scaffolds, allowing for concentration of target analyte(s) (e.g., biomolecule(s)) into a particular phase of the ATPS or into a leading front. Accordingly, in various embodiments methods and devices are provided that utilize aqueous two-phase systems and hydrogel scaffolds to improve the sensitivity of assays (e.g., of point-of-care assays) without sacrificing cost or ease of use.

Abstract: It was discovered that hydrogel scaffolds can be used to induce phase separation as aqueous two-phase systems (ATPSs) pass through and/or rehydrate the scaffolds, allowing for concentration of target analyte(s) (e.g., biomolecule(s)) into a particular phase of the ATPS or into a leading front. Accordingly, in various embodiments methods and devices are provided that utilize aqueous two-phase systems and hydrogel scaffolds to improve the sensitivity of assays (e.g., of point-of-care assays) without sacrificing cost or ease of use.

Abstract: A visualization system for monitoring performance data of an electrical power distribution network is provided. In one embodiment, a user may select a network circuit and view a network circuit diagram that includes indicia representing transformers and other electrical power distribution network elements positioned on a map. The relative positions of the indicia on the network circuit diagram may correspond to the relative physical locations of the transformers in the geographical area represented by the map. The indicia may be color coded to convey performance data to the user.

Abstract: A visualization system for monitoring performance data of an electrical power distribution network is provided. In one embodiment, a user may select a network circuit and view a network circuit diagram that includes indicia representing transformers and other electrical power distribution network elements positioned on a map. The relative positions of the indicia on the network circuit diagram may correspond to the relative physical locations of the transformers in the geographical area represented by the map. The indicia may be color coded to convey performance data to the user.

Abstract: A visualization system for monitoring performance data of an electrical power distribution network is provided. In one embodiment, a user may select a network circuit and view a network circuit diagram that includes indicia representing transformers and other electrical power distribution network elements positioned on a map. The relative positions of the indicia on the network circuit diagram may correspond to the relative physical locations of the transformers in the geographical area represented by the map. The indicia may be color coded to convey performance data to the user.

Abstract: A visualization system for monitoring performance data of an electrical power distribution network is provided. In one embodiment, a user may select a network circuit and view a network circuit diagram that includes indicia representing transformers and other electrical power distribution network elements positioned on a map. The relative positions of the indicia on the network circuit diagram may correspond to the relative physical locations of the transformers in the geographical area represented by the map. The indicia may be color coded to convey performance data to the user.

Abstract: Materials and methods are provided for producing aptamer therapeutics having fully modified nucleotide triphosphates incorporated into their sequence.

Abstract: The invention relates generally to the field of nucleic acids and more particularly to aptamers useful as therapeutics, diagnostics and in research such as for target validation. The invention further relates to materials and methods for enhancing aptamers for use in therapeutics, diagnostics and research.

Abstract: The invention discloses aptamers capable of binding to Immunoglobulin E (“IgE”) useful as therapeutics in and diagnostics of atopic disease and/or other diseases or disorders in which IgE has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to IgE.

Abstract: Materials and methods are provided to modulate, in a controlled manner, the intracellular deliver of therapeutic agents, including therapeutic oligonucleotides using nucleic acid aptamers.

Abstract: The invention provides peptides with high affinity for streptavidin. These peptides may be expressed as part of fusion proteins to facilitate the detection, quantitation, and purification of proteins of interest.

Abstract: Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.

Abstract: Materials and methods are provided for producing aptamer therapeutics having modified nucleotide triphosphates incorporated into their sequence. The aptamers produced by the methods of the invention have increased stability and half life.

Abstract: A device (32) determines the location of a fault in an underground cable causing an earth leakage path from an internal conductor to earth at the location of the fault, such that when a signal is applied to the conductor, an earth leakage signal flows between the earth and conductor at the location of the fault. A multi-frequency signal is applied to the cable, this having at least two frequency components. Probes (24a, 24b) are positionable to receive the earth leakage signal. A processor (50) rectifies a first component of the earth leakage signal, corresponding to one frequency component of the applied signal, multiplies the rectified first component of the earth leakage signal with a second component of the earth linkage signal, corresponding to another frequency component of the applied signal, and from the result of that multiplication indicates the direction from the device to the fault.