Abstract: Disclosed are methods for treating a patient suffering from osteogenesis imperfecta comprising administering to the patient a therapeutically effective amount of an anti-sclerostin antibody. Methods for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient by administering to the patient a therapeutically effective amount of an anti-sclerostin antibody are also disclosed. Further disclosed are compositions for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient. The compositions comprise a therapeutically effective amount of an anti-sclerostin antibody. The invention also provides an anti-sclerostin antibody for use in the treatment of osteogenesis imperfecta.

Abstract: Disclosed are methods for treating a patient suffering from osteogenesis imperfecta comprising administering to the patient a therapeutically effective amount of an anti-sclerostin antibody. Methods for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient by administering to the patient a therapeutically effective amount of an anti-sclerostin antibody are also disclosed. Further disclosed are compositions for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient. The compositions comprise a therapeutically effective amount of an anti-sclerostin antibody. The invention also provides an anti-sclerostin antibody for use in the treatment of osteogenesis imperfecta.

Abstract: A decoupling apparatus for use in a wellbore includes a top sub section and a bottom sub section rotationally coupled to the top sub section. The bottom and top sub sections are aligned along a decoupling apparatus axis. A torque ring is disposed between the top sub section and the bottom sub section. A method for decoupling a lower tubular section from an upper tubular section of a stuck downhole tubular string including the decoupling apparatus includes identifying the stuck downhole tubular string. A first torque is applied to an upper tubular section to rotate a top sub section from a first configuration to a second configuration. A second torque is applied to the upper tubular section to rotate the top sub section from the second configuration to a third configuration in which the top and bottom sub sections are decoupled from one another.

Abstract: A structural support apparatus for positioning in a downhole tubular string includes a support structure base and a liner ring having a first contact load surface in contact with a contact load surface of the base. A fastening mechanism is positioned between the base and the liner ring, where the fastening mechanism is configured to prevent movement of the liner ring relative to the base. A method for fastening a liner ring to a support structure apparatus in a downhole tubular string includes positioning a first contact load surface of the liner ring along a contact load surface of a support structure base. A second contact load surface of the liner ring is positioned along a frangible disk. A fastening mechanism is positioned between the base and the liner ring, where the fastening mechanism is configured to prevent movement of the liner ring relative to the base.

Abstract: Disclosed are methods for treating a patient suffering from osteogenesis imperfecta comprising administering to the patient a therapeutically effective amount of an anti-sclerostin antibody. Methods for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient by administering to the patient a therapeutically effective amount of an anti-sclerostin antibody are also disclosed. Further disclosed are compositions for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient. The compositions comprise a therapeutically effective amount of an anti-sclerostin antibody. The invention also provides an anti-sclerostin antibody for use in the treatment of osteogenesis imperfecta.

Abstract: Stimulation sleeve (1) for well intervention in a subterranean wellbore, comprising: a housing (10) having a through channel (11) with a first end (11a) and a second end (11b), and one or more flow ports (14), and a sliding sleeve (13) disposed axially movable within the housing (10) to open or close said flow ports (14). Said sliding sleeve (13) is equipped with at least a first obturator seat (15) for receipt of a obturator (17) to partially or fully close fluid communication in the through channel (11) of the housing (10), and a time delay mechanism (20) to allow the sliding sleeve (13) to axially travel in the housing (10) at a predetermined speed to open or close said flow ports (14). The invention also discloses a method for well completion in a subterranean wellbore using a sliding sleeve (1).

Abstract: Packer setting device, comprising a tubular (10) with a plug housing (14), said plug housing having an internal, through running boring (12) with an internal wall (12a), a breakable plug (16) seated in a load ring (22) axially movable within the boring (12) between a first position in where the plug (16) is with a distance to a breaking pin (18) and a second position in where the plug (16) is forced against the breaking pin (18), said load ring (22) is resting on a shear ring (20) with an annular shear lip (20a) to prevent axial movement in the first position until the shear lip (20a) is subjected to a force higher than a predetermined force, wherein the annular shear lip (20a) of the shear ring (20) extend radially inward in the boring (12), and the breaking pin (18) is resting on the shear ring (20), and said breaking pin (18) is accommodated in a pocket (28) on an outside of the load ring (22).

Abstract: Downhole well completion system for control of flow to or from multiple compartments (1a,1b,1c,1d) in a targeted subterranean reservoir (30), comprising a plurality of interval control valves (2) connected in series forming a downhole string (24), said interval control valves (2) are manipulated from surface via hydraulic control lines (4a, 4b, 4c) to open or close flowports (20) of each interval control valve (2), wherein each interval control valve (2) comprises a command module (5) connected to at least two of said hydraulic control lines (4a, 4b), a first hydraulic control line is a command line (4a) to deliver applied pressure to the command module (5), which translates hydraulic pressure signals into axial movement of an inner ratchet rod (6) that determines the position of an integral pilot valve (7), a second hydraulic control line is a common-open or common-close line (4b), to provide hydraulic power to either open or close the flowports (20) of each interval control valve (2), and the inner ratchet

Abstract: Disclosed are methods for treating a patient suffering from osteogenesis imperfecta comprising administering to the patient a therapeutically effective amount of an anti-sclerostin antibody. Methods for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient by administering to the patient a therapeutically effective amount of an anti-sclerostin antibody are also disclosed. Further disclosed are compositions for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient. The compositions comprise a therapeutically effective amount of an anti-sclerostin antibody. The invention also provides an anti-sclerostin antibody for use in the treatment of osteogenesis imperfecta.

Abstract: Disclosed are methods for treating a patient suffering from osteogenesis imperfecta comprising administering to the patient a therapeutically effective amount of an anti-sclerostin antibody. Methods for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient by administering to the patient a therapeutically effective amount of an anti-sclerostin antibody are also disclosed. Further disclosed are compositions for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient. The compositions comprise a therapeutically effective amount of an anti-sclerostin antibody. The invention also provides an anti-sclerostin antibody for use in the treatment of osteogenesis imperfecta.

Abstract: Downhole well completion system for control of flow to or from multiple compartments (1a,1b,1c,1d) in a targeted subterranean reservoir (30), comprising a plurality of interval control valves (2) connected in series forming a downhole string (24), said interval control valves (2) are manipulated from surface via hydraulic control lines (4a, 4b, 4c) to open or close flowports (20) of each interval control valve (2), wherein each interval control valve (2) comprises a command module (5) connected to at least two of said hydraulic control lines (4a, 4b), a first hydraulic control line is a command line (4a) to deliver applied pressure to the command module (5), which translates hydraulic pressure signals into axial movement of an inner ratchet rod (6) that determines the position of an integral pilot valve (7), a second hydraulic control line is a common-open or common-close line (4b), to provide hydraulic power to either open or close the flowports (20) of each interval control valve (2), and the inner ratchet

Abstract: Disclosed are methods for treating a patient suffering from osteogenesis imperfecta comprising administering to the patient a therapeutically effective amount of an anti-sclerostin antibody. Methods for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient by administering to the patient a therapeutically effective amount of an anti-sclerostin antibody are also disclosed. Further disclosed are compositions for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient. The compositions comprise a therapeutically effective amount of an anti-sclerostin antibody. The invention also provides an anti-sclerostin antibody for use in the treatment of osteogenesis imperfecta.

Abstract: Stimulation sleeve (1) for well intervention in a subterranean wellbore, comprising: a housing (10) having a through channel (11) with a first end (11a) and a second end (11b), and one or more flow ports (14), and a sliding sleeve (13) disposed axially movable within the housing (10) to open or close said flow ports (14). Said sliding sleeve (13) is equipped with at least a first obturator seat (15) for receipt of a obturator (17) to partially or fully close fluid communication in the through channel (11) of the housing (10), and a time delay mechanism (20) to allow the sliding sleeve (13) to axially travel in the housing (10) at a predetermined speed to open or close said flow ports (14). The invention also discloses a method for well completion in a subterranean wellbore using a sliding sleeve (1).

Abstract: Stimulation sleeve (1) for well intervention in a subterranean wellbore, comprising: a housing (10) having a through channel (11) with a first end (11a) and a second end (11b), and one or more flow ports (14), and a sliding sleeve (13) disposed axially movable within the housing (10) to open or close said flow ports (14). Said sliding sleeve (13) is equipped with at least a first obturator seat (15) for receipt of a obturator (17) to partially or fully close fluid communication in the through channel (11) of the housing (10), and a time delay mechanism (20) to allow the sliding sleeve (13) to axially travel in the housing (10) at a predetermined speed to open or close said flow ports (14). The invention also discloses a method for well completion in a subterranean wellbore using a sliding sleeve (1).

Abstract: Disclosed are methods for treating a patient suffering from osteogenesis imperfecta comprising administering to the patient a therapeutically effective amount of an anti-sclerostin antibody. Methods for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient by administering to the patient a therapeutically effective amount of an anti-sclerostin antibody are also disclosed. Further disclosed are compositions for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient. The compositions comprise a therapeutically effective amount of an anti-sclerostin antibody. The invention also provides an anti-sclerostin antibody for use in the treatment of osteogenesis imperfecta.

Abstract: Packer setting device, comprising a tubular (10) with a plug housing (14), said plug housing having an internal, through running boring (12) with an internal wall (12a), a breakable plug (16) seated in a load ring (22) axially movable within the boring (12) between a first position in where the plug (16) is with a distance to a breaking pin (18) and a second position in where the plug (16) is forced against the breaking pin (18), said load ring (22) is resting on a shear ring (20) with an annular shear lip (20a) to prevent axial movement in the first position until the shear lip (20a) is subjected to a force higher than a predetermined force, wherein the annular shear lip (20a) of the shear ring (20) extend radially inward in the boring (12), and the breaking pin (18) is resting on the shear ring (20), and said breaking pin (18) is accommodated in a pocket (28) on an outside of the load ring (22).

Abstract: Disclosed are methods for treating a patient suffering from osteogenesis imperfecta comprising administering to the patient a therapeutically effective amount of an anti-sclerostin antibody. Methods for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient by administering to the patient a therapeutically effective amount of an anti-sclerostin antibody are also disclosed. Further disclosed are compositions for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient. The compositions comprise a therapeutically effective amount of an anti-sclerostin antibody. The invention also provides an anti-sclerostin antibody for use in the treatment of osteogenesis imperfecta.

Abstract: Disclosed are methods for treating a patient suffering from osteogenesis imperfecta comprising administering to the patient a therapeutically effective amount of an anti-sclerostin antibody. Methods for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient by administering to the patient a therapeutically effective amount of an anti-sclerostin antibody are also disclosed. Further disclosed are compositions for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient. The compositions comprise a therapeutically effective amount of an anti-sclerostin antibody. The invention also provides an anti-sclerostin antibody for use in the treatment of osteogenesis imperfecta.

Abstract: Stimulation sleeve (1) for well intervention in a subterranean wellbore, comprising: a housing (10) having a through channel (11) with a first end (11a) and a second end (11b), and one or more flow ports (14), and a sliding sleeve (13) disposed axially movable within the housing (10) to open or close said flow ports (14). Said sliding sleeve (13) is equipped with at least a first obturator seat (15) for receipt of a obturator (17) to partially or fully close fluid communication in the through channel (11) of the housing (10), and a time delay mechanism (20) to allow the sliding sleeve (13) to axially travel in the housing (10) at a predetermined speed to open or close said flow ports (14). The invention also discloses a method for well completion in a subterranean wellbore using a sliding sleeve (1).

Abstract: An active lightning protection system and method is disclosed. According to one embodiment of the invention, the active lightning protection system includes a charge sensor that senses the build-up of charge associated with an imminent lightning strike in the proximity of a structure and a charge source to supply an opposite charge into the proximity to offset the build-up, thereby reducing the possibility of a strike to the structure.