Abstract: A continuous feed lyophilizer drying chamber that has an overall internal volume, a primary drying stage portion having a primary drying stage internal volume, a secondary drying stage portion having an internal volume, a frozen formulation feed inlet that provides frozen formulation droplets into the internal volume of the primary drying stage of the drying chamber and a dried particle outlet proximate an end of the continuous feed lyophilizer drying chamber configured to provide dried formulation droplet particles. The primary drying stage typically makes up from about 65-75% of the overall internal volume of the drying chamber and the secondary drying stage makes up from 25 to 35% of the overall internal volume of the drying chamber. The drying chamber dries frozen formulation droplets received into the primary drying stage internal volume via the frozen formulation feed inlet.

Abstract: The present invention provides a method of modifying the behavior of a modeled system from a graphical representation of the behavior of the system. Given a graphical representation of the behavior of a modeled system, one or more bounds may be selected for the behavior on the graphical representation. The necessary parameters for the modeled system are then determined for producing the desired behavior based on the selected bounds for the behavior.

Abstract: A high isolation voltage optocoupler includes spaced apart emitter and detector elements coupled to one and the other ends of a bar of light transmissive dielectric material. A reflective coating on the surface of the bar enhances light coupling. An opaque dielectric housing excludes ambient light and provides mechanical support for the coupling elements.