Patents by Inventor Anthony Letai

Anthony Letai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF DETERMINING CELLULAR CHEMOSENSITIVITY
    Publication number: 20160258933
    Abstract: The present invention provides methods of determining cell sensitivity to a therapeutic agent.
    Type: Application
    Filed: March 17, 2016
    Publication date: September 8, 2016
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventor: Anthony Letai
  • METHODS OF BH3 PROFILING
    Publication number: 20160231314
    Abstract: In various aspects the invention provides methods of predicting sensitivity of a cancer cell to a therapeutic agent by contacting a test cell population BH3 domain peptide; measuring the amount of BH3 domain peptide induced mitochondrial outer membrane permeabilization in the test cell population; and comparing the amount of BH3 domain peptide induced mitochondrial outer membrane permeabilization in the test cell population to a control cell population that has not been contacted with the therapeutic agent. An increase in mitochondrial membrane permeabilization in the test cell population compared to the control cell population indicates the cell is sensitive to the therapeutic agent.
    Type: Application
    Filed: September 18, 2014
    Publication date: August 11, 2016
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: Jeremy Ryan, Anthony Letai
  • BH3 PEPTIDES AND METHODS OF USE THEREOF
    Publication number: 20160200786
    Abstract: The invention provides peptides and the nucleic acid sequences that encode them. The invention further provides therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of apoptosis associated disorders.
    Type: Application
    Filed: March 17, 2016
    Publication date: July 14, 2016
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: Stanley J. Korsmeyer, Anthony Letai
  • DYNAMIC BH3 PROFILING
    Publication number: 20150362479
    Abstract: The present invention provides methods of predicting cell sensitivity or resistance to a therapeutic agent.
    Type: Application
    Filed: September 19, 2013
    Publication date: December 17, 2015
    Inventors: Anthony Letai, Juan Jose Montero Boronat, Jeremy Ryan
  • METHODS OF DETERMINING CELLULAR CHEMOSENSITIVITY
    Publication number: 20130149718
    Abstract: The present invention provides methods of determining cell sensitivity to a therapeutic agent.
    Type: Application
    Filed: May 23, 2012
    Publication date: June 13, 2013
    Applicant: Dana Farber Cancer Institute
    Inventor: Anthony Letai
  • Methods of determining cellular chemosensitivity
    Patent number: 8221966
    Abstract: The present invention provides methods of determining cell sensitivity to a therapeutic agent.
    Type: Grant
    Filed: April 2, 2007
    Date of Patent: July 17, 2012
    Assignee: Dana Farber Cancer Institute
    Inventor: Anthony Letai
  • BH3 Peptides And Method Of Use Thereof
    Publication number: 20110154522
    Abstract: The invention provides peptides and the nucleic acid sequences that encode them. The invention further provides therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of apoptosis associated disorders.
    Type: Application
    Filed: December 13, 2010
    Publication date: June 23, 2011
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: Stanley J. Korsmeyer, Anthony Letai
  • BH3 peptides and method of use thereof
    Patent number: 7868133
    Abstract: The invention provides peptides and the nucleic acid sequences that encode them. The invention further provides therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of apoptosis associated disorders.
    Type: Grant
    Filed: April 24, 2007
    Date of Patent: January 11, 2011
    Assignee: Dana Farber Cancer Institute, Inc.
    Inventors: Stanley J. Korsmeyer, Anthony Letai
  • BH3 peptides and method of use thereof
    Publication number: 20080234201
    Abstract: The invention provides peptides and the nucleic acid sequences that encode them. The invention further provides therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of apoptosis associated disorders.
    Type: Application
    Filed: April 24, 2007
    Publication date: September 25, 2008
    Inventors: Stanley J. Korsmeyer, Anthony Letai
  • Methods of Determining Cellular Chemosensitivity
    Publication number: 20080199890
    Abstract: The present invention provides methods of determining cell sensitivity to a therapeutic agent.
    Type: Application
    Filed: April 2, 2007
    Publication date: August 21, 2008
    Inventor: Anthony Letai
  • BH3 peptides and method of use thereof
    Publication number: 20040171809
    Abstract: The invention provides peptides and the nucleic acid sequences that encode them. The invention further provides therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of apoptosis associated disorders.
    Type: Application
    Filed: September 9, 2003
    Publication date: September 2, 2004
    Inventors: Stanley J. Korsmeyer, Anthony Letai