Abstract: A treatment for vulnerable plaque may include a device having a polymeric coating that contains a statin and/or one or more other drugs, where the statin and/or one or more other drugs may be locally released in a sustained fashion at the point of insertion of the device. The coating may coat a self-expanding or balloon expanding structure, such as a fibrous or thin-film structure, intended to reduce the occurrence or severity of restenosis. The coating may be applied to a gently expanding device that reduces vessel trauma by virtue of exerting a low force of expansion against the vessel wall. The coating may be an absorbable polymer on an implantable device such that the absorbable polymer coating degrades at a specified rate to reduce the risk of “late” thrombosis. An anti-thrombogenic agent may also be disposed on or in the absorbable polymer coating to eliminate residual polymer on the surface after the coating is absorbed.