Abstract: A computing system for executing a simulation of a tactical engagement configured to receive a first set of data comprising an indication that a laser sensor worn by a participant was struck by a laser transmitted from a firearm; and receive a second set of data from the firearm comprising data generated by an image capture device of the firearm and an indication that one or more of the participants are present in the data. The computing system is further configured to retrieve data comprising position information and velocity information on the participants that are present in the second set of data. The computing system is further configured to identify a target participant from the participants identified in the second set of data; determine whether the target participant is struck by a simulated ammunition round fired from the firearm; and determine a final outcome for the tactical engagement.

Abstract: A computing system for executing a simulation of a tactical engagement configured to receive a first set of data comprising an indication that a laser sensor worn by a participant was struck by a laser transmitted from a firearm; and receive a second set of data from the firearm comprising data generated by an image capture device of the firearm and an indication that one or more of the participants are present in the data. The computing system is further configured to retrieve data comprising position information and velocity information on the participants that are present in the second set of data. The computing system is further configured to identify a target participant from the participants identified in the second set of data; determine whether the target participant is struck by a simulated ammunition round fired from the firearm; and determine a final outcome for the tactical engagement.

Abstract: A computing system for executing a simulation of a tactical engagement configured to receive a first set of data comprising an indication that a laser sensor worn by a participant was struck by a laser transmitted from a firearm; and receive a second set of data from the firearm comprising data generated by an image capture device of the firearm and an indication that one or more of the participants are present in the data. The computing system is further configured to retrieve data comprising position information and velocity information on the participants that are present in the second set of data. The computing system is further configured to identify a target participant from the participants identified in the second set of data; determine whether the target participant is struck by a simulated ammunition round fired from the firearm; and determine a final outcome for the tactical engagement.

Abstract: The present application generally relates to multi-specific molecules that bind to multiple bacterial virulence factors, methods for producing these binding molecules, and the use of these binding molecules to treat bacterial infections. In particular, the binding molecules comprise at least two binding domains, preferably an antibody or antibody fragment and an alternative scaffold. The first binding domain is capable of binding to a glycosylated staphylococcal surface protein, preferably an SDR-containing protein. The second binding domain is capable of binding to a staphylococcal leukotoxin, preferably LukAB, LukD or LukE. These multi-specific binding compounds have killing activity against staphylococci and, thus, can be used in the treatment and/or amelioration of a Staphylococcus infection, including methicillin-resistant Staphylococcus aureus.

Abstract: The present application generally relates to multi-specific molecules that bind to multiple bacterial virulence factors, methods for producing these binding molecules, and the use of these binding molecules to treat bacterial infections. In particular, the binding molecules comprise at least two binding domains, preferably an antibody or antibody fragment and an alternative scaffold. The first binding domain is capable of binding to a glycosylated staphylococcal surface protein, preferably an SDR-containing protein. The second binding domain is capable of binding to a staphylococcal leukotoxin, preferably LukAB, LukD or LukE. These multi-specific binding compounds have killing activity against staphylococci and, thus, can be used in the treatment and/or amelioration of a Staphylococcus infection, including methicillin-resistant Staphylococcus aureus.

Abstract: The present application generally relates to multi-specific molecules that bind to multiple bacterial virulence factors, methods for producing these binding molecules, and the use of these binding molecules to treat bacterial infections. In particular, the binding molecules comprise at least two binding domains, preferably an antibody or antibody fragment and an alternative scaffold. The first binding domain is capable of binding to a glycosylated staphylococcal surface protein, preferably an SDR-containing protein. The second binding domain is capable of binding to a staphylococcal leukotoxin, preferably LukAB, LukD or LukE. These multi-specific binding compounds have killing activity against staphylococci and, thus, can be used in the treatment and/or amelioration of a Staphylococcus infection, including methicillin-resistant Staphylococcus aureus.

Abstract: The present application generally relates to multi-specific molecules that bind to multiple bacterial virulence factors, methods for producing these binding molecules, and the use of these binding molecules to treat bacterial infections. In particular, the binding molecules comprise at least two binding domains, preferably an antibody or antibody fragment and an alternative scaffold. The first binding domain is capable of binding to a glycosylated staphylococcal surface protein, preferably an SDR-containing protein. The second binding domain is capable of binding to a staphylococcal leukotoxin, preferably LukAB, LukD or LukE. These multi-specific binding compounds have killing activity against staphylococci and, thus, can be used in the treatment and/or amelioration of a Staphylococcus infection, including methicillin-resistant Staphylococcus aureus.

Abstract: Fluorescent probes that have binding affinity to ribosomes. The fluorescent probes are useful tools for identifying small molecules that bind to the 50S or 30S subunits of the bacterial and other ribosomes and serve as novel ribosome inhibitors. These probes are also useful for determining the interactions between a specific ligand and the ribosome.